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REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways Research Article REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways Janelle Drouin-Ouellet1,†, Shong Lau1,†, Per Ludvik Brattås1, Daniella Rylander Ottosson1, Karolina Pircs1, Daniela A Grassi1, Lucy M Collins2,

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_embo_mol_med.pdf - 2026-06-30

Five years into the present peacebuilding cycle in Colombia, violence is increasing again. In the Putumayo department, social-ecological conflicts between the state, armed groups and local communities persist. Social leaders, often representing local communities, are targets of violent actions and represent an extremely vulnerable group. In the Putumayo, at least 67 social leaders defending human

Pharmaceutical industry funding of patient organizations raises ethical challenges related to patient engagement in healthcare due to fears of commercial agendas influencing patient advocacy and creating industry-driven inequalities across patient organizations. We contribute to an international body of knowledge on patient organization–industry relations by analyzing all payments reported by comp

Continuous supermacroporous chromatographic columns with anion-exchange ligands [2-(dimethylanlino)ethyl group] and immobilized metal affinity (IMA) ligands (Cu2+-loaded iminodiacetic acid) have been developed allowing binding of Escherichia coli cells and the elution of bound cells with high recoveries. These poly(acrylamide)-based continuous supermacroporous columns have been produced by radical

Progress with respect to enrichment and separation of native membrane components in complex lipid environments, such as native cell membranes, has so far been very limited. The reason for the slow progress can be related to the lack of efficient means to generate continuous and laterally fluid supported lipid bilayers (SLBs) made from real cell membranes. We show in this work how the edge of a hyd

Fuel properties have a strong impact on the efficiency of internal combustion engines. Contrary to other physical and thermochemical fuel properties, the molar expansion ratio is normally ignored. Molar expansion ratio is the ratio of number of moles of the products to the reactants. In this work, the impact of the fuel's molar expansion ratio on engine efficiency is investigated. Findings are bas

Analogical transfer, denoting the ability to use an action that solved a given problem in order to successfully handle a seemingly different but functionally similar problem, requires well- developed self-regulation, as it draws on previous knowledge and demands selecting and shift- ing between relevant features while ignoring irrelevant ones. Thus, analogical transfer involves executive functions

The conventional method to manufacture prosthetic arms is a time-\\consuming and complicated process. It is a process that has many manual steps that allow much room for human errors. With today's technology advancement it is possible to offer a more efficient technology that can replace the conventional manufacturing method of prostheses. This master thesis aims to develop a new way of manufa

Enantioselective synthesis is an important research topic with applications in drug development. Asymmetrical catalysis is one of the available ways of producing enantioenriched products. C2-Symmetric dibenzo[a,e]cyclooctenes or dbCOTs are a family of versatile chiral ligands for transition metals. They display great efficiency and enantioselectivity in 1,2- and 1,4- additions reactions. In this

Move-to-play is a musical instrument for persons with both cognitive and physical impairments, who would have trouble playing traditional instruments. Everyone, no matter their abilities, are given the chance to play and control music by moving their own body. This project is part of the MISK project, which is a collaboration between Certec, Furuboda folkhögskola and Eldorado resurscenter. To make

To reduce the use of resources, as well as to minimize the effluents of carbon dioxide; we need to use our products for a longer time. Repairs makes that possible and is considered a key strategy to move towards a more circular economy (CE). Sweden recently presented its CE action plan, which includes few direct initiatives that would foster repairs. Therefore, through a literature review, policy

Regional integration on the African continent has been promoted for decades as a means to sustained economic development in Africa, with multiple agreements on the continent to stimulate such integration. Many countries are members of these regional integration organizations on the basis of increasing intra-regional trade and cooperation. This study is a comparative analysis between two countries

The aim of this thesis work was to form and characterize model systems of cell membranes on planar supports and in micropipettes. Firstly, supported lipid bilayers (SLBs) were formed on glass slides after an existing experimental procedure. It was shown possible to obtain fluid SLBs from different kinds of lipids as well as on glass slides that were cleaned with different techniques. Custom-writte

Efterfrågan av alkoholfri öl ökar och det finns många olika anledningar till att dricka alkoholfri öl såsom graviditet, religion, arbete eller om man ska köra bil. Men det finns idag ingen enkel och billig metod för att producera välsmakande alkoholfri öl. De vanligaste metoderna för att producera alkoholfri öl på marknaden är utspädning, destillation, omvänd osmos samt att inte fermentera vörten.The demand of alcoholic free beer is increasing and there are many reasons to choose alcoholic free beer such as pregnancy, religion, work or before driving. But today there doesn’t exist a simple, cheap method to produce well tasting alcoholic free beer. The existing methods on the market to produce alcoholic free beer are dilution, distillation, reverse osmosis and to avoid fermenting the wort.

In China, the past 30 years have been characterized by economic growth and rapid development that has transformed the nation into an important player on the international market. This phenomenal progress probably would have been impossible without the cheap labor force provided by the Chinese countryside in the form of migrant workers. Millions of rural people circulate the nation today in order t

This essay contains a study of the Swedish aid discourse. By use of the theory about historicism by Dipesh Chakrabarty I aim to find what representations are found within the discourse, and what subject positions exists about the countries who receive aid, and the countries, in this case Sweden, who give aid. Through discourse analysis and my theoretical framework containing of post-colonial theor