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Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors : A feasibility study

Introduction: Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between s

Refined parameters of the HD 22946 planetary system and the true orbital period of planet d

Context. Multi-planet systems are important sources of information regarding the evolution of planets. However, the long-period planets in these systems often escape detection. These objects in particular may retain more of their primordial characteristics compared to close-in counterparts because of their increased distance from the host star. HD 22946 is a bright (G = 8.13 mag) late F-type star

Machine learning for early prediction of acute myocardial infarction or death in acute chest pain patients using electrocardiogram and blood tests at presentation

Aims: In the present study, we aimed to evaluate the performance of machine learning (ML) models for identification of acute myocardial infarction (AMI) or death within 30 days among emergency department (ED) chest pain patients. Methods and results: Using data from 9519 consecutive ED chest pain patients, we created ML models based on logistic regression or artificial neural networks. Model input

Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative

PurposeIn early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and Nottingham histologic grade (NHG)—are used to determine prognosis and treatment. We aimed to develop classifiers for these biomarkers that were based on tumor mRNA sequencing (RNA-seq), compare classification performance, a

Abstract P3-02-02: Concordance between immunohistochemical and gene-expression based subtyping of early breast cancer using core needle biopsies and surgical specimens - experices from SCAN-B

Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information. Treatment decisions in these cases rely on biomarker assessments and subtyping from tissue acquired through core needle biopsies. Tumor heterogeneity and representativity are pit-falls when limited tissue is available. Biomarker expression may change conside

Spectral light absorption by ambient aerosols influenced by biomass burning in the Amazon Basin. I : Comparison and field calibration of absorption measurement techniques

Spectral aerosol light absorption is an important parameter for the assessment of the radiation budget of the atmosphere. Although on-line measurement techniques for aerosol light absorption, such as the Aethalometer and the Particle Soot Absorption Photometer (PSAP), have been available for two decades, they are limited in accuracy and spectral resolution because of the need to deposit the aeroso

On the date of composition of Additions B and E to LXX Esther

Additions B and E to LXX Esther have been variously dated from the second century BCE to the first century CE. This study links the two Greek Additions, on the one hand, with Philo’s writings through the concept of the “evil-hating justice” and, on the other hand, with the historical persons and events related to the Jewish-Alexandrian conflict of 38-41 CE, and dates their composition or final red

VADEMECUM, 77 Minor Terms for Writing Urban Places: Minor Urbanism

Writing Urban Places proposes an innovative investigation and implementationof a process for developing human understanding ofcommunities, their society, and their situatedness. By recognising thevalue of local urban narratives – stories rich in information regardingcitizens socio-spatial practices, perceptions and expectations – theAction aims to articulate a set of concrete literary devices with

Perception of slipperiness, thermal comfort and wearability of footwear used on icy surfaces

The objectives of this study are to assess the perception of slipperiness, thermal comfort, and wearability of footwear used on icy surfaces, and the anti-slip effect of materials spread on ice using outdoor walking trials. Twenty-five subjects wore four types of footwear walking on five different icy surfaces. Five-point rating scale was used recording wearer's perception. The results showed that

Evaluation of the plant phenology index (PPI), NDVI and EVI for start-of-season trend analysis of the Northern Hemisphere boreal zone

Satellite remote sensing of plant phenology provides an important indicator of climate change. However, start of the growing season (SOS) estimates in Northern Hemisphere boreal forest areas are known to be challenged by the presence of seasonal snow cover and limited seasonality in the greenness signal for evergreen needleleaf forests, which can both bias and impede trend estimates of SOS. The ne

Visual Staging of Meaning: Exploring the Borders of Religion, Identity and Politics : Organizer and moderator of panel at Fourth World Congress of Middle Eastern studies (WOCMES), Ankara, Turkey

This panel is devoted to an exploration of multimodal, visual staging of meaning in the Middle East and its transnational interconnectedness. Presentations will discuss examples of visual inventiveness in different and multimodal medial contexts, varying both in terms of motivations, positions of power and visual strategies employed. The panel invites reflection on how the study of current visual

Climate change impact on water balance and export of dissolved organic carbon : a sub-catchment modelling approach

Att förutsäga framtiden – modellering som ett verktyg för att förutsäga vattenkvantitet och vattenkvalitet Inom 100 år så kommer klimatet förändrats avsevärt om utsläpp av växthusgaser fortsätter i samma takt som idag. Detta kommer påverka temperatur, nederbörd vilka i sin tur påverkar flödet av vatten i Sverige. Ett avrinningsområde består av olika jordtyper, vegetation och topografi, vilka allClimate change will alter the hydrological cycle in the 21st century with implications for the water balance and water quality. As characteristics of the landscape may vary significantly between nearby locations, hydrological models need to be able to delineate responses attributed to specific landscape characteristics, to estimate their responses to altered climatic drivers. Small streams are the

Global Compact for Safe, Orderly and Regular Migration- exkluderande eller inkluderande?

Föreliggande studie,”Global Compact for Safe, Orderly and Regular Migration- eckluderande eller inkluderande?”, har syftat till att undersöka hur irreguljära migranter exkluderas ur migrationsramverket och vilka konsekvenser som kommer av exkluderingen för migranten med hjälp av frågeställningen: ”På vilka sätt har den politiska konsensusen inom ramen för Global Compact for Migration (GCM) osynligThis study,”Global Compact for Safe, Orderly and Regular Migration- exkluding or including?”, has aimed to examine how irregular migrants are being excluded from the Global Compact for Migration, and which consequences the exclusion can bring for the migrants. My question for this study was ”In which ways has the political consensus for the Global Compact for Migration (GCM) isolated the irregular