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International water resources agreements for transboundary rivers in southern Africa are generally founded in system analysis models for water planning and allocation. The Water Resources Yield Model (WRYM) developed in South Africa has so far been the only model applied in official joint water resources studies aimed to form water-sharing agreements. The continuous discussion around the model per
Health care is deficient in many parts of the world, in money, facilities and manpower. In wealthy countries, the costs and complexity of health care are increasing unsustainably. Nevertheless, richer countries claim an ever escalating need for doctors, who migrate from poorer countries, with an ensuing global health workforce crisis. These political, social, demographic and international events n
Implant-assisted targeting of magnetic particles under the influence of an external magnetic field has previously been verified through mathematical modeling, in vitro studies, and in vivo studies on rat carotid arteries as a feasible method for localized drug delivery. The present study focuses on the development of nanoparticles for the treatment of in-stent thrombosis. Magnetic nanoparticles in
The use of electroconvulsive therapy (ECT) varies across countries. The aim of this study was to describe and explore the use of ECT in Sweden in 2013.
This study describes a method to obtain a certain humidity level by a certain drying treatment. This treatment was applied on cement based materials in order to identify the critical moisture level above which ion transport can occur. The drying is performed in two steps, first in one direction to reach a certain moisture level and then in the opposite direction to identify if ions can move at thi
Introduction: Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a well defined cohort of AS patients to the general population seeking care. Methods: The Skane Healthcare Register comprises healthcare data of each resident in Region Skane, Swe
The four-kallikrein panel and the Prostate Health Index (PHI) have been shown to improve prediction of prostate cancer (PCa) compared with prostate-specific antigen (PSA). No comparison of the four-kallikrein panel and PHI has been presented.
The increased opportunity to choose one’s school of preference has been raised as a key factor in many countries to promote equal opportunities and a higher quality of education. This has been endorsed by policymakers who assume that students make well-informed rational choices and that students stress only academic quality when deciding which school to attend. If this is true, it will benefit sch
Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by human studies. We used the mouse quantitative trait loci (QTL) map to interpret resu
Galectin-3 is extensively involved in metabolic and disease processes, such as cancer metastasis, thus giving impetus for the design of specific inhibitors targeting this -galactose-binding protein. Thiodigalactoside (TDG) presents a scaffold for construction of galectin inhibitors, and its inhibition of galectin-1 has already demonstrated beneficial effects as an adjuvant with vaccine immunothera
Popular Abstract in Swedish Avhandlingen är en granskning av ett antal psykologiska metoder i syfte att förbättra bedömning/diagnostik av två olika tillstånd förknippade med kontakt med kemikalier: (1) kronisk nedsättning av hjärnfunktion till följd av långvarig kontakt med lösningsmedel i yrket (toxisk encefalopati, förkortat TE), och (2) överkänslighet för kemikalielukter av okända orsaker (eng.The dissertation deals with psychological methods aimed at improving the understanding and assessment of two disorders related to contact with chemicals: solvent-induced chronic toxic encephalopathy (TE) and multiple chemical sensitivity (MCS). The main aim of Paper I was to study whether the addition of some newer psychological tests of complex attention and executive functions to a traditional
Popular Abstract in Swedish Sedan kartläggningen av det mänskliga genomet, har mer fokus lagts på dess produkt, proteomet, som definieras som de proteiner som uttrycks i en cell vid en viss tidpunkt. Proteomets dynamiska egenskaper gör det till en fantastisk källa för så kallade biomarkörer, det vill säga molekyler som genom deras koncentrationsmönster kan användas för att särskilja sjuka och frisMultiplex protein quantification, proteomics, is essential for uncovering new biomarkers and understanding biology. Liquid chromatography coupled to mass spectrometry (LC-MS) is the predominant technique for these measurements. In this thesis, optimization and quality control strategies for different phases of the LC-MS pipeline have been developed. Due to the inherent complexity and dynamic rang
A simple analytical model for the link loss between two very low profile wireless body area network transceivers located at the same level on the human torso is presented. The model is based on the attenuation of the creeping waves on an elliptical approximation of the human torso. A good agreement between the model and the FDTD simulations on realistic heterogeneous phantoms of different age and
Popular Abstract in Swedish Partikelfysiken är studien av naturens minsta beståndsdelar --- De så kallade \emph{elementarpartiklarna}. All materia i universum består av elementarpartiklar. Den teori som beskriver vilka partiklar som finns och hur de uppför sig heter \emph{Standardmodellen}. Teorin har historiskt sett varit mycket framgångsrik. Den har gång på gång förutspått existensen av nya partThis thesis documents my work in the luminosity and supersymmetry groups of the ATLAS experiment at the Large Hadron Collider. The theory of supersymmetry and the concept of luminosity are introduced. The ATLAS experiment is described with special focus on a luminosity monitor called LUCID. A data-driven luminosity calibration method is presented and evaluated using the LUCID detector. This method
Purpose: Supply chain efficiency (economic and ecological) is affected by packaging design. The purpose of this research is to investigate how integrated approaches aiming for ecoefficient supply chains are used in packaging development processes and how a set of preselected factors influences the adaption of more or less integrated approaches at companies. Design/methodology/approach: The researc
This report is produced within the Urban Transition Øresund (UT) project (2011–2014), and it is part of the subtask Collaborative Methods and Tools for Urban Transitions (UT CoMeT). The goal of the UT project is to promote sustainable growth and advance sustainable urban transformation in the Øresund region by gathering municipalities, universities and businesses in cross-border cooperation. The s
Popular Abstract in Swedish Wnt-5a-genens betydelse för bröstcellernas normala funktion och för uppkomsten av bröstcancer I min avhandling har jag studerat en i bröstcancersammanhang hittills föga undersökt gen, Wnt-5a. Benämningen Wnt har bildats genom en sammanslagning av "Wingless" (den första identifierade Wnt-genen som orsakar vinglöshet hos bananflugan) och "Int" (från "Integration site" föThe Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. Inasmuch as Wnt-5a can activate the Wnt/beta-catenin signalling pathway, we performed experiments to determine whether mol
