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To further develop and evaluate a pharmacophore model previously proposed by Cook and co-workers (Drug Des. Discovery 1995,12,193-248) for ligands binding to the benzodiazepine site of the GABA(A) receptor, 40 new flavone derivatives have been synthesized and their affinities for the benzodiazepine site have been determined. Two new regions of steric repulsive interactions between ligand and recep
The results of a search for direct pair production of heavy top-quark partners in 4.7 fb(-1) of integrated luminosity from p p collisions at root s = 7 TeV collected by the ATLAS detector at the LHC are reported. Heavy top-quark partners decaying into a top quark and a neutral non-interacting particle are searched for in events with two leptons in the final state. No excess above the Standard Mode
Cation exchange chromatography has been routinely used for the quantification of monoclonal antibody (mAb) charge heterogeneity. A previously developed method utilizing pH gradients for the elution instead of salt gradients was validated according to current guidelines proposed by the ICH. The linearity, stability, accuracy, precision and the lower limit of quantification have been determined, usi
Dr Lisbeth NilssonLearning objectives:1. Describe at least three essential aspects of the facilitating approach.2. Explain why these aspects can facilitate optimal outcomes of intervention.3. Evaluate usefulness of the universal facilitating approach in your own practice.Session description:The process of learning joystick-use and training strategies for each phase in the process were identified i
Study design: Longitudinal prospective cohort study. Objectives: To assess the effects of Active Rehabilitation (AR) training programmes for individuals with spinal cord injury (SCI) on physical independence, self-efficacy and wheelchair skills, and to identify factors that are associated with gains in these outcomes. Setting: Eight consecutive AR programmes in Sweden. Methods: Participants (n = 1
A series of Na0.67Ni0.33Mn0.67-xSnxO2 (x = 0, 0.01, 0.03, 0.05) materials with mixed P2/P3 phases are synthesized with a conventional solid-state reaction method and investigated as cathode materials for sodium ion batteries. The effects of Sn substitution on the structure and electrochemical performance of the Na0.67Ni0.33Mn0.67O2 are systematically investigated. The substituted samples show smal
We present the time-resolved luminescence end station developed at the FemtoMAX beamline at the MAX IV Laboratory for the studies of ultrafast energy relaxation and emission properties. The instrument consists of a temperature-controlled vacuum chamber sample environment, in which the UV–visible luminescence is collected from the point of interaction of ultrashort x-ray pulses with luminescent mat
Introducing a sociological perspective on judicial emotions, we argue that previous studies underemphasize structural andinteractional dimensions. Through key concepts in the sociology of emotions we relate professional court actors’ emotionmanagement to the emotional regime of the judiciary. Examples from the Swedish judiciary illustrate three main arguments:(a) The idea of rational justice as noIntroducing a sociological perspective on judicial emotions, we argue that previous studies underemphasize structural andinteractional dimensions. Through key concepts in the sociology of emotions we relate professional court actors’ emotionmanagement to the emotional regime of the judiciary. Examples from the Swedish judiciary illustrate three main arguments:(a) The idea of rational justice as no
The aim of this paper is directly linked to the context within which it has been drafted, as ecological debt (including climate debt) has been identified as a key Ejolt concept, one that is in need of better elucidation if EJOs are to operationalize its possibilities in their ongoing activities. Readers of this paper (and especially EJO activists) should in this way not only find themselves introd
Modern safe and high-quality products not only need to have desired properties in terms of geometry, material, features, etc. from a position-interaction point of view. Also compliance, deflection, impact and safety features depending on force-interacting properties are of (increasing) importance. As a key such example, the mechanical response of car seats has been studied, including the contact f
Regional cerebral blood flow was measured with the 133-Xenon inhalation method in seven healthy subjects with orthostatic hypotension not due to autonomic failure (i.e. non-neurogenic clinical disorder). Measurements were performed during supine rest and during head-up tilt (70 degrees). All subjects had a consistent drop in systolic blood pressure and the typical symptomatology of orthostatic hyp
In this work, a first-order upwind and a high-order flux-limiter schemes for solving the advection–diffusion equation on unstructured grids were evaluated. The numerical schemes were implemented as a module of an unstructured two-dimensional depth-averaged circulation model for shallow lakes (IPH-UnTRIM2D), and they were applied to the Guaíba River in Brazil. Their performances were evaluated by c
In a population-based group of women, consecutively diagnosed, with premenopausal breast cancer there was a significant correlation between tumour size and plasma prolactin (r=0.30;P<0.004). The concentration of estrogen receptor was negatively correlated to tumour size (r=-0.17;P<0.09). There were no substantial correlations between tumour size and progesterone receptor, plasma progesterone or es
Many animals have been shown to use the pattern of polarized light in the sky as an optical compass. Specialised photoreceptors are used to analyse this pattern. We here present evidence for an eye design suitable for polarized skylight navigation in the flightless desert scarab Pachysoma striatum. Morphological and electrophysiological studies show that an extensive part of the dorsal eye is equi
