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BackgroundVariants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine-rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late-onset sporadic disorders like Parkinson's disease. MethodsThe Genetic Epidemiology of Parkinson's Disease Consortium recently
When flying through narrow spaces, insects control their position by balancing the magnitude of apparent image motion (optic flow) experienced in each eye and their speed by holding this value about a desired set-point. Previously, it has been shown that when bumblebees encounter sudden changes in the proximity to nearby surfaces - as indicated by a change in the magnitude of optic flow on each si
Haemophilus influenzae protein E (PE) is a multifunctional adhesin, involved in direct interactions with lung epithelial cells and host proteins, including plasminogen and the extracellular matrix proteins vitronectin and laminin. We recently crystallized PE and successfully collected X-ray diffraction data to 1.8 Å. Here we solved the structure of a recombinant version of PE and analyzed differen
Background: In audiologic practice, complementary information sources and access to the clinician between appointments improve information retention and facilitate adjustment behaviors. An Internet-based support system is a novel way to support information sharing and clinician access. Purpose: This research forum article describes the process of developing an Internet-based support system for aud
Most known starfish species possess a compound eye at the tip of each arm, which, except for the lack of true optics, resembles an arthropod compound eye. Although these compound eyes have been known for about two centuries, no visually guided behaviour has ever been directly associated with their presence. There are indications that they are involved in negative phototaxis but this may also be go
Women in the UK prefer the faces of men with low levels of the stress hormone cortisol, and the relationship is moderated by the sex hormone testosterone. In a Latvian sample, however, women's preferences were not affected by cortisol, and the interaction with testosterone differed from that of the UK. To further explore cross-cultural variation in preferences for facial cues to sex- and stress-ho
Routine monitoring of the quality of stroke care is becoming increasingly important since patient outcomes could be improved with better access to proven treatments. It remains unclear how many countries have established a national registry for monitoring stroke care.
Climate reconstructions from data sensitive to past climates provide estimates of what these climates were like. Comparing these reconstructions with simulations from climate models allows to validate the models used for future climate prediction. It has been shown that for fossil pollen data, gaining estimates by inverting a vegetation model allows inclusion of past changes in carbon dioxide valu
In this paper, a new application of resonant acoustic spectroscopy (RAS) is examined for constructing asphalt concrete mastercurves from seismic testing. The frequency-dependent material properties can be characterized from multiple modes of vibration through the use of RAS. Beam-shaped asphalt specimens are tested at multiple temperatures to determine the resonance frequencies of the specimens. T
Nonsuicidal self-injury (NSSI) in adolescents is a significant problem that needs to be addressed, and in some cases managed, in school settings. The current feasibility study uses screening questionnaires and follow up-interviews on NSSI in a community sample of adolescents (N ¼ 1,052) in Sweden. Both adolescents reporting self-injury (n ¼ 66) and a comparison group (n ¼ 31) were interviewed, and
Recent public debates about sexuality in India and Vietnam have brought the rights of lesbian, gay, bisexual and transgender people sharply into focus. Drawing on legal documents, secondary sources and ethnographic fieldwork conducted in the urban centres of Delhi and Hanoi, this article shows how the efforts of civil society organisations dedicated to the fight for lesbian, gay, bisexual and tran
The use of intravenous artificial oxytocin for augmentation of labour is very common in midwifery care in Sweden. Studies have shown that oxytocin is often administered to women in labour who have no signs of labour dystocia. It was the aim of this study to examine Swedish midwives' views on and experiences of labour augmentation in the context of normal labour. Individual interviews were carried
The ATLAS detector is used to search for excited leptons in the electromagnetic radiative decay channel l* -> l gamma. Results are presented based on the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 2.05 fb(-1). No evidence for excited leptons is found, and limits are set on the compositeness scale Lambda as a function of the excited le
Taking a global perspective this paper sets out to theoretically and empirically identify prosperity patterns for four groups of countries at different levels of economic development. It conceptualizes ‘prosperity’ in terms of ecological sustainability, social inclusion, and the quality of life and contextualizes this definition in global perspective. Subsequently, it operationalizes and measures
The aim of this paper is to present an alternative method for the analysis of resistivity data. The methodology was developed during a study to evaluate if electrical resistivity can be used as a tool for analysing subsurface gas dynamics and gas emissions from landfills. The main assumption of this study was that variations in time of resistivity data correspond to variations in the relative amou
To develop an innovative information and communication technology (ICT) tool intended to help older people in their search for optimal housing solutions, a first step in the development process is to gain knowledge from the intended users. Thus the aim of this study was to deepen the knowledge about needs and expectations about housing options as expressed and prioritized by older people, people a
A constitutive model for diffusionless phase transitions in elastoplastic materials undergoing large deformations is developed. The model takes basic thermodynamic relations as its starting point and the phase transition is treated through an internal variable (the phase fractions) approach. The usual yield potential is used together with a transformation potential to describe the evolution of the
The increased demand for clean power in recent years has led to the development of various processes that include different types of CO2 capture. Several options are possible: pre-combustion concepts (fuel de-carbonization and subsequent combustion of H2), post-combustion concepts (tail-end CO2 capture solutions, such as amine scrubbing), and integrated concepts in which combustion is carried out
Clay minerals cannot only give information on sedimentary depositional environment but also the climate regime under which sediment was weathered. The successions of non-marine to marine Middle and Late Jurassic strata of the East European Platform show upwards increasing contents of smectite and decreasing contents of kaolinite. There is also an increasing smectite vs. kaolinite ratio laterally,
