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Analogs of the incretin hormones Gip and Glp-1 are used to treat type 2 diabetes and obesity. Findings in experimental models suggest that manipulating several hormones simultaneously may be more effective. To identify small molecules that increase the number of incretin-expressing cells, we established a high-throughput in vivo chemical screen by using the gip promoter to drive the expression of
Background: There is growing attention and policy debate about the sharing of personal information that the modernization of electricity grids requires. This is particularly important for big data management in smart grids that needs access to data generated and sent through devices such as smart meters. Using the Nordic Countries as a case study, this study investigates the willingness of people
The construction of interfacial engineered heterojunctions is an effective strategy to broaden the optical response and facilitate charge separation. Herein, a novel 0D/1D Ag2S/Sb2S3 heterojunction is prepared by in-situ growth of Ag2S quantum dots on Sb2S3 nanorods using a simple hydrothermal approach. The 10% Ag2S/Sb2S3 (10AS) heterojunction exhibited efficient CO2 photoreduction activity with a
OBJECTIVES: Our aim was to derive, based on the SWEDEHEART registry, and validate, using the Western Denmark Heart registry, a patient-oriented risk score, the SweDen score, which could calculate the risk of 1-year mortality following a myocardial infarction (MI).METHODS: The factors included in the SweDen score were age, sex, smoking, diabetes, heart failure and statin use. These were chosen a pr
Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of PSA screening, PrCa incidence, positive predictive value of PSA, biopsy, and tumour characteristics after 3 yr of screening, by BR
This paper develops a model based on the concept of Positive Mathematical Programming (PMP) that is useful for ex-ante analyses of how policy measures affect commercial fisheries. PMP models are frequently used in agriculture, but rarely for analyzing fisheries. Fisheries often face a large set of constraints such as effort regulations and catch quotas of which some might be binding and others not
Standing wave ambient pressure photoemission spectroscopy (SWAPPS) is a promising method to investigate chemical and potential gradients across solid-vapor and solid-liquid interfaces under close-to-realistic environmental conditions, far away from high vacuum. Until now, these investigations have been performed only near room temperature, but for a wide range of interfacial processes, chief among
The Soil and Water Assessment Tool (SWAT) model has been widely applied for simulating the water cycle and quantifying the influence of climate change and anthropogenic activities on hydrological processes. A major uncertainty of SWAT stems from the poor representation of vegetation dynamics due to the use of a simplistic vegetation growth and development module. Using long-term remote sensing-bas
Mechanical behavior of meniscus can be modeled using constitutive material models of varying complexity, such as isotropic elastic or fibril reinforced poroelastic (FRPE). However, the FRPE material is complex to implement, computationally demanding in 3D geometries, and simulation is time-consuming. Hence, we aimed to quantify the most suitable and efficient constitutive model of meniscus for sim
Within the Action Plan for Humanitarian Adaptation to Climate Change initiated by the German Federal Foreign Office a new and innovative framework to humanitarian action is developed, the forecast-based financing mechanism. This scientifically based funding system shall enable practitioners and donors to react faster to oncoming natural extreme events, while supporting local communities in adaptin
As previous research on content-specificity of the neural correlates of recollection is inconclusive, event-related potentials were used to assess old/new effects for faces, objects and words. The data demonstrate temporal differences in ERP old/new effects as a function of item type, supporting the notion that material-dependent processes underlie recollection-related neural activity. The results
We test a new approach to calculate the mean velocity and velocity dispersion for a sample of nearby stars when their radial velocities are not available. The most commonly used method (here called the projection method, PM) was introduced in a paper by Dehnen & Binney (1998). That method is here compared, theoretically and numerically, with an application of the Maximum Likelihood (ML) method
Stakeholders’ participation has been recognized as a pillar for a transition toward a more sustainable society. However, there is little empirical evidence concerning the viability of participation mechanisms at large scale. This research analyzes a popular referendum process in Switzerland against a law that would have been a step toward a low-carbon society in the Canton of Fribourg. Aiming to i
Attention to the role of religious NGOs (RNGOs) in international arenas has grown in the past decade. This study explored the role of values in the policies of RNGOs involved in humanitarian aid. It sought to compare the values of RNGOs with varying levels of involvement with the Steering Committee for Humanitarian Response (SCHR) in order to determine if values may be an issue inhibiting cooperat
The upcoming changes in the demographic structure will put pressure on the healthcare system in Skåne. Tax financed hospitals with more beds, doctors, nurses and other personnel will not be the solution to cope with the upcoming demands. Increasing healthcare productivity is one way, where digital healthcare is a potential part of the solution. One of the major limitations of the digital healthcar
Today’s work environment is currently undergoing radical changes and although the aware-ness of social collaboration is growing within organizations, they still struggle with the digital transformation and thereby with the integration of Enterprise Social Network (ESN). Our study aims to investigate the role of ESN within the todays’ organizations. Specifically, it intends to build on previous res
