Filtyp
Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp
Observations of low-mass stars have frequently shown a disagreement between observed stellar radii and radii predicted by theoretical stellar structure models. This ‘radius inflation’ problem could have an impact on both stellar and exoplanetary science. We present the final results of our observation programme with the CHaracterising ExOPlanet Satellite (CHEOPS) to obtain high-precision light cur
Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov
Accessible design enables participation in the digital society for everyone. However, cognitive accessibility is not well established within the field of web design. The International Classification of Functioning, Disability and Health (ICF) provides a descriptive framework that relates health conditions to functioning and participation. ICF Core Sets are purposefully tailored shortlists of ICF c
To predict major pressure losses from pumping shear thinning liquid foods and beverage, rheometer-measured flow behaviour (n) and flow consistency (K) indices are needed. These are always obtained with some measurement uncertainty. This contribution develops a tool that allows for quantitatively estimating how a given measurement uncertainty in the rheological parameters translate to predictio
Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de
BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl
Climate change is one of the major drivers of biodiversity loss. Among vertebrates, amphibians are one of the more sensitive groups to climate change due to their unique ecology, habitat requirements, narrow thermal tolerance and relatively limited dispersal abilities. We projected the influence of climate change on an endemic toad, Malabar Tree Toad (Pedostibes tuberculosus; hereafter MTT) from t
The governance of agricultural resources, particularly seeds, has long been a site of contestation between corporate-aligned institutions promoting proprietary seed laws and smallholder farmers, civil society organisations, and food sovereignty advocates defending traditional seed systems and local control. In Ghana, the introduction and eventual passage of the Plant Variety Protection Act of 2020
The Siusi/Seis section has been measured for the δ13C signature across the Permian-Triassic Boundary (PTB) in high resolution on magnetostratigraphic samples from Scholger et al. (2000), enabling an exact correlation with magnetostratigraphic data. We show that the base of the short normal polarity magnetozone that has been reported from the evento-stratigraphic boundary correlates with a distinct
Tensor-valued encoding in diffusion MRI allows probing of microscopic anisotropy in tissue, however, time-dependent diffusion (TDD) can bias results unless b-tensors are carefully tuned to account for TDD. We propose two novel strategies for tuning b-tensors to enable accurate measurements without interference from TDD due to restricted diffusion. The first strategy involves identifying encoding t
Monitoring toxic elements has a long tradition in Slovenia due to historical mining. More recently, attention has shifted to essential elements, since both deficiencies and excesses can harm health. Regular monitoring of (non-)essential elements supports risk assessment and policymaking. While urine and blood are common biomonitoring matrices, hair offers a non-invasive alternative that reflects e
Access to outdoor leisure activities is central to supporting active and healthy ageing. To address the lack of research on services supporting continued engagement, this study examines how public, voluntary and private sectors provide outdoor recreation services for older adults. This study uses a qualitative research design to draw on interviews, a workshop, and field observations conducted in a
Daylight is crucial for the well-being of individuals in indoor environments, providing numerous physiological and psychological benefits. Achieving satisfactory daylight levels can be particularly challenging during adaptive reuse of existing buildings for new purposes. This study determined the feasibility of adapting an office for residential use by assessing interior daylight availability and
The sector for private domestic services in Sweden has grown rapidly since the RUT tax deduction was introduced in 2007. Already in the government proposition (2006/07:94) it was suggested that services provided by the expanding market would come to replace parts of the publicly funded elderly care, thus marking a shift in the organisation of care in the welfare state. Today we begin to see the ef
We study a simple extension of the Standard Model featuring a dark sector with an ultralight pseudo-Nambu-Goldstone boson as a dark matter candidate. We focus on the mass range O(10-20-10-10) eV, relevant for strong gravity applications, and explore its production and evolution in the early Universe. The model is formulated in such a way that dark matter does not couple directly to photons or othe
Objectives: To determine the impact of the COVID-19 pandemic on the incidence rates of infection and islet autoimmunity in children at risk for type 1 diabetes. Methods: 1050 children aged 4 to 7 months with an elevated genetic risk for type 1 diabetes were recruited from Germany, Poland, Sweden, Belgium and the UK. Reported infection episodes and islet autoantibody development were monitored unti
