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The nucleotide sequence coding for the beta chain of murine C3 was determined from cloned cDNA and genomic DNA fragments. Sonicated subfragments were randomly inserted into the bacteriophage M13 and sequenced using the dideoxynucleotide technique. Each nucleotide was sequenced on average six times in these studies. The derived amino acid sequence includes a signal peptide and a tetra-arginine sequ

The United Nations (UN) Intergovernmental Negotiating Committee (INC) has completed its second round of negotiations on a new international legally binding instrument to ‘end plastic pollution’. This paper examines the results of the second session of negotiations, which took place May 29–June 2, 2023, and analyses the trends, barriers, and themes shaping the emerging legally binding instrument. T

Carpal tunnel syndrome (CTS) occurs more often among individuals with diabetes. The aim of this retrospective observational registry study was to examine whether individuals with diabetes and CTS are treated surgically to the same extent as individuals with CTS but without diabetes. Data on CTS diagnosis and surgery were collected from the Skåne Healthcare Register (SHR). A total of 35,105 individ

Introduction Critical care is essential in saving lives of those that are critically ill, however, provision of critical care can be costly and heterogeneous across lower-resource settings. This paper describes the protocol for a systematic review of the literature that aims to identify the reported costs and resources available for the provision of critical care and the forms of critical care pro

The increasing global demand for energy and the need to reduce industrial emissions have made energy efficiency a central focus in process industries. Therefore, this thesis investigates system-level optimization strategies for a closed-loop cooling system utilizing seawater. A system commonly used in heavy process industries, with a focus on both design and operational improvements. The study eva

Background: Developing new diagnostic imaging methods that provide detailed visualization of the histoanatomy of tissues and organs requires precise histomorphometric evaluation. With a particular focus on bowel, this study aimed to develop and validate a computer program for reliable and efficient assessment of bowel wall histomorphometry. Methods: A MATLAB-based computer program was developed in

Most bacteria with a rod-shape morphology contain an actin-like cytoskeleton consisting of MreB polymers which form helical spirals underneath the cytoplasmic membrane to direct peptidoglycan synthesis for elongation of the cell wall. In contrast MreB of Streptomyces coelicolor is not required for vegetative growth, but has a role in sporulation. Beside MreB, S. coelicolor encodes two further MreB

Introduction: Meniscal extrusion is thought to be associated with less meniscus coverage of the tibial surface, but the association of radiographic disease stage with quantitative measures of tibial plateau coverage is unknown. We therefore compared quantitative and semi-quantitative measures of meniscus position and morphology in individuals with bilateral painful knees discordant on medial joint

Results from a search for supersymmetry in events with four or more leptons including electrons, muons and taus are presented. The analysis uses a data sample corresponding to 20.3 fb(-1) of proton proton collisions delivered by the Large Hadron Collider at root s = 8 TeV and recorded by the ATLAS detector. Signal regions are designed to target supersymmetric scenarios that can be either enriched

Abstract in UndeterminedPicture books and other visual merchandize for children and youth have a central role in Euro-American Sunni Muslim efforts at religious socialization. The proposed paper aims at making some analytical remarks on the complex cultural interplay inherent to the visual aspects of such pedagogic–cum–commercial material.Islamic children’s literature originated in Muslim American

Currently, many Global South countries face an unprecedented debt crisis with large portions of their spending going to debt repayments. This financial restrain hinders their capacity to address basic needs and ecological challenges, particularly as climate change exacerbates vulnerabilities. To provide a solution for this, The Nature Conservancy (TNC) launched their Nature Bonds Program aimed at

We investigate the CCN activity of freshly emitted biomass burning particles and their hygroscopic growth at a relative humidity (RH) of 85%. The particles were produced in the Mainz combustion laboratory by controlled burning of various wood types. The water uptake at sub- and supersaturations is parameterized by the hygroscopicity parameter, κ (c.f. Petters and Kreidenweis, 2007). For the wood b

Parkinson´s disease is characterized by a progressive degeneration of the nigral dopaminergic system. Treatment of disease symptoms using L-DOPA frequently induces side effects such as L-DOPA-induced dyskinesia. New therapeutic approaches are aimed at preventing neurodegeneration or restoring the dopaminergic system by fetal dopaminergic transplants. In this thesis work, we evaluated the neuroprot

Aim/hypothesis Hyperinsulinaemia maintains euglycaemia in insulin-resistant states. The precise cellular mechanisms by which the beta cells adapt are still unresolved. A peripherally derived cue, such as increased circulating fatty acids, may instruct the beta cell to initiate an adaptive programme to maintain glucose homeostasis. When this fails, type 2 diabetes ensues. Because mitochondria play