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Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to i
Sammanfattning av eget föredrag om tidningen Lundagårds symboldjur "Quatten" (hållet för Sällskapet Pelle Svanslös Vänner i Uppsala 2015-11-16)
BACKGROUND: Owing to the wide spread perception of a possible benefit from paclitaxel in the second-line situation the Nordic Gynecologic Oncology Group (NGOG) conducted two prospective phase II studies of paclitaxel single agent treatment (175 mg/m2, three-hour i.v. infusion with standard pre-medication every third week) in patients with relapsing or progressing epithelial ovarian cancer followin
Objective: Homecare workers play a pivotal role in palliative care, but research on their experiences is limited. The aim of this study was to describe how homecare workers in Sweden experience their work in palliative homecare. Method: This qualitative study used open-ended interviews with a purposive sample of 15 homecare workers. The data was analysed by means of qualitative content analysis. R
Writing Urban Places proposes an innovative investigation and implementationof a process for developing human understanding ofcommunities, their society, and their situatedness. By recognising thevalue of local urban narratives – stories rich in information regardingcitizens socio-spatial practices, perceptions and expectations – theAction aims to articulate a set of concrete literary devices with
The hypothalamus is the central regulator of energy homeostasis. Hypothalamic neuronal circuits are disrupted upon overfeeding, and play a role in the development of metabolic disorders. While mouse models have been extensively employed for understanding the mechanisms of hypothalamic dysfunction, functional magnetic resonance imaging (fMRI) on hypothalamic nuclei has been challenging. We implemen
In 2013, the United Nations General Assembly established the High-level Political Forum on Sustainable Development (HLPF) as a central platform for the review and follow-up of the 2030 Agenda and the Sustainable Development Goals (SDGs). Every year, government representatives and societal stakeholders meet to assess progress of SDG implementation. The HLPF can be seen as a soft governance instrume
International organizations within and outside the United Nations system provide platforms for multilateral cooperation and give impulses for national policymaking to promote the implementation of the Sustainable Development Goals (SDGs). They set agendas, coordinate efforts across regions and countries, offer technical assistance and expertise, compile data and monitor progress and raise awarenes
Three new cobalt complexes of the general formula [Co(II)(L)(CH3CN)]2+, where L is one of three pentadentate nitrogen-donor ligands based on the N4Py framework, have been synthesized and characterized. The capacity of the three complexes to effect photocatalytic proton reduction has been examined. Their photocatalytic activities in the presence of [Ru(bpy)3]2+, acting as a photosensitizer, and asc
The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non-tumor cells. This study investigates the potential of selectively targeting γ-tubulin1 (TUBG1) as a therapeutic strategy in cancer treatment. By elucidating the TUBG1-E2F1-retinoblastoma protein (RB1) network, we introduce a novel compound, 4-(6-((3-Met
Famous for its many New Kingdom stelai and funerary shrines, Speos of Horemheb and magnificent quarries, this paper presents a preliminary report on a lesser acknowledged feature of Gebel el Silsila: its quarry marks. Focusing here on the northern section – Partition B – of Silsila East’s Main Quarry, seventeen individual quarry faces display totally 376 quarry marks, which have been divided into
Despite prostate cancer being the most frequent cancer in men in the Western world, tissue biomarkers for predicting disease recurrence after surgery have not been incorporated into clinical practice. Our group has previously identified β-microseminoprotein (MSMB) and cysteine-rich secretory protein-3 (CRISP3) as independent predictors of biochemical recurrence after radical prostatectomy. The pur
In 2019 and 2021, the European League for Rheumatism (EULAR) jointly with the European Renal Association (ERA) and the Kidney Disease: Improving Global Outcomes (KDIGO), respectively, released updated guidelines on the management of lupus nephritis (LN). The Immunology Working Group of the ERA reviewed and compared both updates. Recommendations were either consistent or differences were of negligi
