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The human molecular chaperone protein DNAJB6 was recently found to inhibit the formation of amyloid fibrils from polyglutamine peptides associated with neurodegenerative disorders such as Huntington's disease. We show in the present study that DNAJB6 also inhibits amyloid formation by an even more aggregation-prone peptide (the amyloid-beta peptide, (Aβ42)(2), implicated in Alzheimer's disease)in
Purpose: To characterize the clinical phenotype regarding retinal function and macular appearance in patients with spinocerebellar ataxia type 7 (SCA 7), with an emphasis on electrophysiological findings. Methods: Three patients from two Swedish families were given an ophthalmological examination including visual acuity, fundus inspection, Farnsworth's color vision test, Goldmann perimetry, full-f
Union density remains very high in Sweden. The significantly raised fees for union unemployment funds in January 2007 were followed by an unprecedented decline in the number of union members in modern Swedish history. In the course of two years union density dropped by 6 percentage points: from 77% in 2006 to 71% in 2008. As a result, the density of employers’ associations today is much higher tha
A departing assumption in my work is the idea about a particular kind of conflict inherent in the theatrical line, produced by its situatedness in the specific relational doubt created in the speaking, performing voice and body, a space articulated already in the written line, as writing intended to be spoken. To the inherent self-contradiction in such utterances are added the layers of conscious
Multi-electrode geoelectrical imaging has become very popular and is used for many different purposes. For some of these, the inclusion of IP data would be desirable as it would allow the interpreter to distinguish between, e.g. sand formations with saltwater infiltration and clay formations or help delineate landfills. However, present-day IP measuring techniques require the use of nonpolarisable
Popular Abstract in Swedish En industrirobot är en flexibel programmerbar maskin som bör användas för sådant arbete som inte lämpar sig för människan att utföra. Olika tekniska begränsningar i dagens styrsystem begränsar dock robotars tillämpbarhet. Avhandlingen föreslår ett nytt sätt att bygga upp robotstyrsystem så att roboten på bästa sätt skall kunna tjäna människan.Industrial robots play a key role in manufacturing systems. Robots are distinguished from other types of machinery mainly on the basis of their programmability and ability to be adaptable to different tasks. The use of computer control to achieve desired flexibility implies that software issues for embedded control systems are central for the applicability and utilization of the equipment. The str
A humus soil with a pH of 4.9 was fumigated with chloroform for 5 h, after which only 1% of the initial bacterial activity remained. Half of the fumigated soil was limed to a pH of 7.5. Both the unlimed soil (UL) and the experimentally limed soil (EL) were inoculated with unfumigated (UL) soil or a field-limed (FL) soil with a pH of 6.1. The pH tolerance and activity of each developing bacterial c
Multipotent stem/progenitor cells derived from human first trimester forebrain can be expanded as free-floating aggregates, so called neurospheres. These cells can differentiate into neurons, astrocytes and oligodendrocytes. In vitro differentiation protocols normally yield γ-aminobutyric acid-immunoreactive neurons, whereas only few tyrosine hydroxylase (TH) expressing neurons are found. The pres
The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly reducing infarct size induced by transient middle cerebral artery occlusion (MCAO)
Distal tephra horizons, particularly within lacustrine sequences, are increasingly being used as time-synchronous marker horizons within palaeoclimatic and palaeoenvironmental investigations. As sedimentary features marking the presence of these so-called cryptotephras are absent to the naked eye, it is of some importance that the stratigraphic position representing primary airfall, and likewise t
Degradation of bovine nasal cartilage induced by interleukin-1 (IL-1) was used to study catabolic events in the tissue over 16 days. Culture medium was fractionated by two-dimensional electrophoresis (isoelectric focusing and SDS-PAGE). Identification of components by peptide mass fingerprinting revealed released fragments representing the NC4 domain of the type IX collagen {alpha}1 chain at days
The Homogeneous charge compression ignition (HCCI) principle holds promise to increase efficiency and to reduce emissions from internal combustion engines. As HCCI combustion lacks direct ignition timing control and auto-ignition depends on the operating condition, control of auto-ignition is necessary. Since auto-ignition of a homogeneous mixture is very sensitive to operating conditions, a fast
Under 1800-talet tilltog de antikatolska stämningarna i Europa. Antikatolicismen hämtade sin näring från katolska kyrkans fördömande av såväl protestantismen som den moderna utvecklingen i riktning mot ett sekulärt samhälle. I flera länder utmynnade dessa motsättningar i veritabla sammandrabbningar mellan katolska kyrkan och den av liberala krafter dominerande statsmakten. Man talade om ”kulturka
Survival after childhood cancer has improved substantially over recent decades. Although cancer in childhood is rare increasingly effective treatments have led to a growing number of long-term survivors. It is estimated that there are between 300,000 and 500,000 childhood cancer survivors in Europe. Such good survival prospects raise important questions relating to late effects of treatment for ca
Using in situ surface-sensitive electron microscopy performed in real time, we show that the dynamics of micron-sized Ga droplets on Ga P(111) can be manipulated locally using Au nanoparticles. Detailed measurements of structure and dynamics of the surface from microns to atomic scale are done using both surface electron and scanning probe microscopies. Imaging is done simultaneously on areas with
This study documents the terrestrial palynological record at the John's Nose section, a new Cretaceous-Paleogene (K-Pg) boundary site in North Dakota, USA. In addition to Mud Buttes and Pyramid Butte, John's Nose represents the third K-Pg section in southwestern North Dakota that preserves direct evidence of the Chicxulub asteroid impact, allowing for direct comparison over the timing and trends o
The six chapters of this study approach the work of Cornelis Vreeswijk from different perspectives with an emphasis on the motifs, poetic technique, and intertextuality of individual songs amd Iyrical texts. Vreeswijks s work is interpreted in the context of contemporary history and debate, the cultural tradition to which it belongs and important events in the author's life. The first chapter foc
Popular Abstract in Swedish Denna avhandling sammanfattar studier av en ny biologisk markör för påvisande av alkoholmissbruk. Alkoholmissbruk är ett omfattande hälsoproblem i många delar av världen och Sverige är inte på något sätt undantaget. Man har beräknat att ca 15% av alla män och 10% av alla kvinnor i detta land står för hälften av all alkoholkonsumtion. Det föreligger alltså en onormal förBiological markers offer a way of assessing ethanol intake and determining whether a health problem is alcohol related. This study investigated the use of phosphatidylethanol (PEth) in blood as a new marker of alcohol abuse. PEth is an abnormal phospholipid, formed only in the presence of ethanol via the transphosphatidylation reaction of phospholipase D (PLD). A new HPLC-evaporative light scatter
The metabolic syndrome includes a cluster of dysfunctions that identifies subjects at high risk of developing type 2 diabetes and cardiovascular disease. The prevalence of the metabolic syndrome has increased markedly over the last two decades. Central to this syndrome is insulin resistance and hyperglycaemia, but also other manifestations, e.g. central obesity, dyslipidaemia, elevated blood press
This article is based on a study of the sailing event America’s Cup in Malmö in the late summer of 2005. It serves the purpose of exemplifying a project of urban governance. Urban governance means that municipalities are engaged in implementing different strategies in order to strengthen their own position in the competition between cities and regions. The article’s main theme is the relation betw
