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Background - Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR Standing Committee for Clinical Trials met in 1998 to determine the methodological and logistical approach required for the development of evidence based guidelines for treatment of knee OA. The guidelines were restricted to cover all currently available treatments for knee O

Reaction of Ru3(CO)12 with tris(2-thienyl)phosphine (PTh3) in CH2Cl2 at room temperature or in THF in the presence of a catalytic amount of Na[Ph2CO] furnishes the carbonyl substitution products Ru3(CO)11(PTh3) (1), Ru3(CO)10(PTh3)2 (2), and Ru3(CO)9(PTh3)3 (3). Heating 1 in toluene affords the cyclometalated cluster Ru3(CO)9{μ-Th2P(C4H2S)}(μ-H) (4) resulting from carbonyl loss and carbon-hydrogen

Chemical building blocks for plastics can be produced from renewable biomass feedstocks using microbial production organisms, such as yeast or bacteria, in a biorefinery. One class of chemical building blocks that are suitable for production of biobased and biodegradable plastics are dicarboxylic acids, e.g. succinic acid. In order to avoid competition with food and feed production it is desirable

Patient organisations contribute to many areas of pharmaceutical policy. In developing their organisational capacity, many turn to financial support from pharmaceutical companies, which may create conflicts of interests. However, the transparency of the industry’s self-regulatory approach to the disclosure of payments to patient organisations has evaded scrutiny. Using company reports disclosing p

Chemogenomics data generally refers to the activity data of chemical compounds on an array of protein targets and represents an important source of information for building in silico target prediction models. The increasing volume of chemogenomics data offers exciting opportunities to build models based on Big Data. Preparing a high quality data set is a vital step in realizing this goal and this

Popular Abstract in Swedish När en konsument går längs en gång i en butik kan han eller hon enkelt ta ett mjölkpaket utan att tänka på allt som behövts göras för att det ska kunna hamna på hyllan. Många chefer och ingenjörer lägger ner oerhört mycket energi för att detta ska vara möjligt. För varje paket mjölk omfattar kedjan av olika aktiviteter processande, förpackning, transport och lagring, frIn the supply chain interactions with product and packaging systems, actors place various needs on packaging. Satisfying these needs eventually increases the supply chain efficiency and effectiveness. The aim of the research presented is to contribute to the packaging logistics body of knowledge on reducing the gap between the supply chain needs and satisfying them, through packaging design and de

Wastewater treatment is a worldwide necessity that is even more crucial to countries deprived from abundant fresh water sources or unable to afford advanced and costly processes. With this perspective, this thesis was conducted within an Egyptian-Swedish research collaboration that aimed to develop solar-based (as free renewable energy source available locally) process for hazardous wastewater tre

The objective of the present thesis was to understand how the quality and performance of dried cassava products could be developed by drying and other processing steps. This goal was achieved in several stages. First, a survey of the composition of six cassava varieties from Bolivia, was performed, which resulted in the report of chemical and mineral compositions of the tubers. The mineral composi

1. Background The workgroup of Traffic Psychology is concerned with the social, behavioral, and perceptual aspects that are associated with use and non-use of bicycle helmets, in their various forms and under various cycling conditions. 2. Objectives The objectives of WG2 are to (1) share current knowledge among the people already working in the field, (2) suggest new ideas for research on and eva

Motivation Machine learning offers a powerful approach for building predictive models from high-dimensional molecular data. Omics technologies such as transcriptomics, proteomics, and metabolomics quantify thousands of molecules simultaneously, providing deep insights into disease biology. Integrating multiple modalities can enhance predictive performance, as shown in histology-omics and holter-om

Background. National registries that capture patients with chronic kidney disease (CKD) across all stages are scarce. We present here the Swedish Renal Registry (SRR), a nationwide prospective register covering the whole spectrum of CKD. Methods. Created in 1991, SRR enrolls CKD patients referred to adult nephrologist care (non-dialysis CKD [ND-CKD], kidney transplantation, maintenance dialysis),

Background: The treatment goal of early rheumatoid arthritis is remission. This study reports remission rates in clinical practice using a cohort of patients with early rheumatoid arthritis. Methods: 698 patients with early rheumatoid arthritis were included. Mean age at inclusion was 58 years and mean disease duration was 6.4 months; 64% of the patients were women, 56% were positive for antibodie

We present a calculation of the finite volume corrections to meson masses and decay constants in three flavour Partially Quenched Chiral Perturbation Theory ( PQChPT) through two-loop order in the chiral expansion for the flavour-charged ( or off-diagonal) pseudoscalar mesons. The analytical results are obtained for three sea quark flavours with one, two or three different masses. We reproduce the

A huge quantity of gene and protein sequences have become available during the post-genomic era, and information about genetic variations, including amino acid substitutions and SNPs, is accumulating rapidly. To understand the effects of these changes, it is often essential to apply bioinformatics tools. Where there is a lack of homologous sequences or a three-dimensional structure, it becomes ess

Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of

Det ligger i människans natur att utforska och söka efter det okända. Nu arbetas det hårt för att möta de stora utmaningarna som måste övervinnas för att en bemannad resa till Mars ska bli verklighet. NASA planerar att skicka människor till Mars under 2030-talet och det privata företaget SpaceX har målet att skicka en bemannad farkost till Mars så tidigt som år 2024. Resan till Mars utgör mångfase"Space agencies and privat e companies are working hard to solve the various challenges that need to be overcome to take humans to Mars . The journey to Mars has mult ifaceted risks for the crew, includin g radiation exposure. One risk factor that could jeopar dize t he crew's healt h is the radiation dose from a !arge solar partide event (SPE)

Unmanned vehicles need robust systems to ensure the safety of the vehicle and its environment. Being able to find and avoid perilous situations is paramount to such a system. In this paper we suggest an unsupervised image-based anomaly detection algorithm using a variational autoencoder and a superpixel segmentation algorithm, which is adapted to the maritime obstacle detection task. The algorithm