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Several organic cations, such as guanidino compounds and polyamines, have been found to accumulate in plasma of patients with kidney failure due to inadequate renal clearance. Here, we studied the interaction of cationic uremic toxins with renal organic cation transport in a conditionally immortalized human proximal tubule epithelial cell line (ciPTEC). Transporter activity was measured and valida
Giant bamboo plantations are currently being established in the Southern Africa region and can be considered as potential lignocellulosic feedstock for the production of second generation bioethanol. In this study, giant bamboo internodal material was subjected to sulphur dioxide (SO2) impregnated steam pretreatment prior to enzymatic hydrolysis. The effect of temperature, residence time, and acid
Avtal kan, med vissa undantag, omfatta i stort sett vad som helst. Varje dag ingås enormt många avtal och den vanligaste typen av avtal torde vara rena köpeavtal. Trots att denna typ av avtal generellt sett har ett liknande innehåll och ändamål, d.v.s. parterna avtalar i regel om en naturaprestation och en penningprestation, kan avtalens utformning variera. Detta inkluderar givetvis de påföljder sAgreements may, with certain exceptions, include basically anything. Each day enormous number of agreements are concluded and the most common type of agreement is probably the purchase agreement. Although this type of agreements generally have a similar content and purpose, i.e. the parties generally agree on one performance in kind and one in money, the design of agreements may vary. This of cour
En proglacial miljö är en integrerad del av ett glacialt landskap, där smältvattensavlagrade landformer är vanligt förekommande. Deras utseende är beroende av ett antal olika faktorer, så som processer aktiva under transport och deposition samt ursprungsmaterialets karaktär. Denna artikel syftar till att undersöka två terrestra smältvattens-successioner från de terminala delarna av glaciären MyrdaProglacial environments are an integrated part of the glacier landscape, housing a variety of landforms fed by glacier meltwater. Their appearance is dependent on a number of factors, such as the variability of source material and processes active during the transportation and deposition. The present work aims to investigate two such terrestrial outwash successions from the terminus region of the
The objective of this thesis is to increase the organization's knowledge about Life Cycle Assessment (LCA), so Perstorp Form can organize the development of know-how and meet the demands from customers. An LCA project was initiated to identify? necessary changes as well as clarify how LCA can be used together with other management tools. The experience from the LCA study, the so-called Gilde
Popular Abstract in Uncoded languages Kronična upala je u podlozi mnogih bolesti modernog čovjeka kao što su djiabetes, astma, ateroskleroza itd. Upalu predvode različiti tkivni makrofagi. Proteini iz porodice galektina, proizvedeni u makrofagima, dodatno pridonose razvoju bolesti, stoga je od velikog interesa odgonetnuti različite funkcije galektina. Ovaj rad nastoji identificirati specifične uloContemporary diseases like diabetes, asthma, atherosclerosis etc. are marked by chronic inflammation, often supported by the activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. The aim of this thesis was to pin-point specific galectin-3 roles in
Cerebral Palsy, commonly referred to as CP, is a neurological disorder that results in loss or impairment of motor function, which affects body movement, muscle control, muscle coordination and balance. In Sweden, about 200 children are diagnosed with Cerebral Palsy every year and the disorder can cause imbalances between the muscles. These imbalances can lead to contractures which is equiva- lent
Thesis purpose: The aim of this study is to identify enablers and constraints for consumers to adopt food waste reduction apps. Consequently, it contributes to the field of innovation diffusion and, importantly, consumer adoption of technological innovations. Methodology: This exploratory study uses qualitative methods to investigate consumer values, expectations and experiences as the main unit
In this work the photoelectric effect is explored through simulations of the phase shift that an IR-field can induce into an electron wave packet and the photoelectron distribution over frequency components that is produced in the photoionization of an atom with a attosecond pulses made of XUV photons. The IR-field is sent along two attosecond pulses made of XUV photons towards a 3D momentum spect
The importance of food on achieving sustainability has been a topic increasingly moved to the forefront of the international debate. Thus, governments from around the globe have developed and adopted comprehensive food policies aiming at sustainable development. As part of this, public procurement has been identified as a powerful tool leveraging government’s purchasing power and holding an intere
Digital 3D city models are used in many GIS applications, such as urban planning. Manual digitization of 3D buildings is rather tedious, hence automated approaches are much preferred. In this study, a pipeline for automated extraction and estimation of building roof facets from LIDAR data are devised based on available methods and ideas, which is part of the entire frame work of automatic creating
Wild bees are declining in intensively farmed regions worldwide, threatening pollination services to flowering crops and wild plants. To halt bee declines, it is essential that conservation actions are based on a mechanistic understanding of how bee species utilize landscapes. We aimed at teasing apart how foraging resources in the landscape through the nesting season affected nesting and reproduc
The issue of securing access to patented pharmaceutical products has been in the forefront of global legal debate for many years. This debate intensified further following the enactment of the TRIPSTRIPS agreement and the global enforcement of Intellectual Property Rights such as patents through the World Trade Organization. To combat the problem, compulsory licensingCompulsory licensing has been
Background: Treatment of postoperative pain remains a significant clinical problem, and prediction of patients with a risk of higher postoperative pain levels is an important focus. We aimed to identify patients undergoing total hip arthroplasty (THA) with risk of higher pain levels at 24 h postoperatively by using four simple and easily available clinical tools. Methods: This prospective observat
The aim of this study was to identify molecules that trigger complement activation in rheumatic joints. C4d, the final cleavage product of C4 activation, is found in the diseased joint and can bind covalently to complement-activating molecules. By using a highly specific Ab against a cleavage neoepitope in C4d, several molecules that were specifically bound to C4d were identified from pooled synov
This thesis presents important steps towards performing high-intensity attosecond pump-probe experiments at the Lund high-intensity extreme ultraviolet (XUV) beamline, which followed two complementary paths: maximization of the XUV intensity available in the interaction region with a gas target, and providing attosecond temporal resolution.To maximize the energy of the XUV pulses generated via hig
In higher plants, genes for subunits of respiratory chain complex I (NADH:ubiquinone oxidoreductase) have so far been identified solely in organellar genomes. At least nine subunits are encoded by the mitochondrial DNA and 11 homologues by the plastid DNA. One of the 'key' components of complex I is the subunit binding the substrate NADH. The corresponding gene for the mitochondrial subunit has no
RATIONALE: Tandem mass (MS/MS) spectra generated by collision-induced dissociation (CID) typically lack redundant peptide sequence information in the form of e.g. b- and y-ion series due to frequent use of sequence-specific endopeptidases cleaving C- or N-terminal to Arg or Lys residues.METHODS: Here we introduce arginyl-tRNA protein transferase (ATE, EC 2.3.2.8) for proteomics. ATE recognizes aci
The oxidation reactions of alkanes with hydrogen peroxide and peracids (peracetic acid (PAA) and m-chloroperoxybenzoic acid (mCPBA)) catalysed by two Fe(II) complexes of pentadentate {N5}-donor ligands have been investigated. Kinetic isotope effect experiments and the use of other mechanistic probes have also been performed. While the total yields of oxidized products are similar regardless of oxi
