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Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the

The key role of tropical forest belowground carbon stocks and fluxes is well recognised as one of the main components of the terrestrial ecosystem carbon cycle. This study presents the first detailed investigation of spatial and temporal patterns of fine root stocks and fluxes in tropical forests along an elevational gradient, ranging from the Peruvian Andes (3020 m) to lowland Amazonia (194 m), w

Msc in Service Management, Retail MSc in Service Management, Retail LUND UNIVERSITY | SWEDEN • Master of Science with a major in Service Management • 2 years, full-time, 120 ECTS credits • Department of Service Studies • Campus Helsingborg • Application deadline: January 2024 • Programme start: August 2024 PROGRAMME OVERVIEW The Master’s Programme in Service Management is a unique opportunity for

https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/2023-09/Msc-in-service-management-retail-factsheet-2024.pdf - 2026-06-08

PowerPoint-presentation Sharing Cities Stockholm – can the sharing economy facilitate climate transition, locally in a city district? Dr Charlie Gullström, KTH Royal Institute of Technology Digitalisation and interactive architecture Sharing Cities Stockholm – Testbed Hammarby Sjöstad  Sharing Cities Sweden 2017-2020  Viable Cities, Swedish strategic innovation programme for smart sustainable ci

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/stockholm.pdf - 2026-06-08

Background: Synaptic dysfunction and degeneration are central contributors to the pathogenesis and progression of parkinsonian disorders. Therefore, identification and validation of biomarkers reflecting pathological synaptic alterations are greatly needed and could be used in prognostic assessment and to monitor treatment effects. Objective: To explore candidate biomarkers of synaptic dysfunction

The EU Biodiversity strategy aims to plant 3 billion trees by 2030, in order to improve ecosystem restoration and biodiversity. Here, we compute the land area that would be required to support this number of newly planted trees by taking account of different tree species and planting regimes across the EU member states. We find that 3 billion trees would require a total land area of between 0.81 a

Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating >500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems. We impute genotypes u

The standard prognostic marker for multiple myeloma (MM) patients is the revised International Staging System (R-ISS). However, there is room for improvement in guiding treatment. This applies particularly to older patients, in whom the benefit/risk ratio is reduced because of comorbidities and subsequent side effects. We hypothesized that adding gene-expression data to R-ISS would generate a stro

Objective: Worse women's outcomes after elective standard endovascular aneurysm repair have been widely reported. Similar data have surfaced from cohorts undergoing fenestrated and branched repair; however, studies reporting from a sex perspective are rare and mostly limited to single centre designs. This study aimed to examine survival following nationwide complex endovascular repair according to

Background: Quantitative fecal immunochemical test (FIT) is widely used for colorectal cancer (CRC) screening, with substantial variation in positivity thresholds across countries. This study examines how these thresholds affect FIT's diagnostic performance for detecting CRC and advanced precancerous lesions (APCL). Methods: We analyzed data from a single round screening of 7398 men and women aged

The recast Energy Performance of Buildings Directive introduces binding Minimum Energy Performance Standards for existing non-residential buildings, requiring Member States to identify and renovate the worst-performing segments of their building stock. This study develops and applies an integrated framework for evaluating energy renovation measures in office buildings, addressing building category

The focus of this thesis is to examine how the civic identity of the second-generation migrants in Italy is constructed through media representations of migration, citizenship, and national belonging. Previous studies focused on migrants’ integration, which was based on their socio-economic situation, mobility, and assimilation process. I argue that these approaches are insufficient to explain how

Introduction Aggrecanase cleavage at the (392)Glu-(393)Ala bond in the interglobular domain (IGD) of aggrecan, releasing N-terminal (393)ARGS fragments, is an early key event in arthritis and joint injuries. Here, we use a quantitative immunoassay of aggrecan ARGS neoepitope fragments in human synovial fluid to determine if this cleavage-site specific method better identifies joint pathology than

Prevention of obesity should have the highest priority and be started as early in life as possible in high-risk families. This article covers the most promising areas of today's research aimed at finding better ways of treating obesity in the future and an overview of the treatment choices available today. The cause of obesity is genetic in approximately 40-50 percent of adults and probably to a h

Thomson ORIGINAL ARTICLE: GASTROENTEROLOGY: CELIAC DISEASE Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study Sibylle Koletzko, yHye-Seung Lee, zAndreas Beyerlein, §Carin A. Aronsson, zMichael Hummel, jjEdwin Liu, Ville Simell, #Kalle Kurppa, §Åke Lernmark, William Hagopian, yyMarian Rewers, zzJin-Xiong She, §§jjjjOlli Simell, §§Jorma Toppari, zAnette-G. Ziegler, yJe

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/73%2010262018_679_73_MP74_Koletzko_J%20Pediatr%20Gastroenterol%20Nutr_2017.pdf - 2026-06-08

Background: Genome-wide association studies (GWAS) have emerged as a powerful approach for identifying susceptibility loci associated with polygenetic diseases such as type 2 diabetes mellitus (T2DM). However, it is still a daunting task to prioritize single nucleotide polymorphisms (SNPs) from GWAS for further replication in different population. Several recent studies have shown that genetic var

Background and purpose - Treatment of Dupuytren's contracture (DC) with collagenase Clostridium histolyticum (CCH) consists of injection followed by finger manipulation. We used a modified method, injecting a higher dose than recommended on the label into several parts of the cord, which allows treatment of multiple joint contractures in 1 session and may increase efficacy. We studied the occurren

Chemotherapy of castration resistant prostate cancer (CRPC) is based on taxane formulations worldwide. Only 30-50 % of patients respond to this therapy and the exact cellular mechanisms of taxane resistance in PC cells are not fully elucidated. There is convincing evidence that androgen receptor (AR) is affected by exposure to these compounds. The studies presented in this doctoral thesis identify

Popular Abstract in Swedish Den pågående globaliseringen skapar ett behov av ökad kommunikationskompetens bland svenskar som arbetar ute i världen. Denna studie baseras på beskrivningar av de kommunikationsprocesser som används av svenskar, när de möter icke-svenskar på yrkets vägnar vid arbete utanför Sverige. Beskrivningarna baseras på intervjuer. Studien är inriktad på tre områden. De kommunikaGlobalization creates a need for increased communication competence among Swedes working on the global arena. This study is based on reports of communication processes used by Swedes when interacting professionally with non-Swedes. The reports are derived from interviews. The study focuses on three areas. The communication strategies developed by the respondents for intercultural communication. Th

In this study, the spatial representativeness of eddy covariance (EC) methane (CH4) measurements was examined by comparing parallel CH4 fluxes from three short (6 m) towers separated by a few kilometres and from two higher levels (20 m and 60 m) at one location. The measurement campaign was held on an intensively managed grassland on peat soil in the Netherlands. The land use and land cover types