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Popular Abstract in Swedish Det kvinnliga könshormonet östrogen utövar sin effekt via två bindningsprotein (receptorer) benämnda ERa och ERb. Då östrogen binder till receptorn aktiverar alternativt inaktiverar detta komplex sekvenser av DNA molekylen. Således reglerar den aktiverade receptorn för östrogen genaktivitet och därmed syntes av proteiner viktiga för den normala cell- och vävnadsfunktionEstrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. The objective of this thesis was to inve

Metal affinity tags have been fused to proteins and demonstrated to function as tools in protein purification, protein stabilisation, quantitative metal analysis and metal tolerance of bacteria and plants. In biotechnological applications proteins frequently have to function in nonnatural environments with harsh conditions which impose requirements for high stability on the proteins. Metal affini

Power to the People examines the varied but interconnected relationships between energy consumption and economic development in Europe over the last five centuries. It describes how the traditional energy economy of medieval and early modern Europe was marked by stable or falling per capita energy consumption, and how the First Industrial Revolution in the eighteenth century--fueled by coal and st

Advances in understanding how cancer cells interact with the immune system allowed the development of immunotherapeutic strategies, harnessing patients’ immune system to fight cancer. Dendritic cell-based vaccines are being explored to reactivate anti-tumor adaptive immunity. Immune checkpoint inhibitors and chimeric antigen receptor T-cells (CAR T) were however the main approaches that catapulted

BACKGROUND: For muscle-invasive bladder cancer (MIBC), no tissue biomarkers are available for clinical use to predict response to neoadjuvant chemotherapy.OBJECTIVE: To investigate how molecular subtypes impact pathological response and survival in patients receiving preoperative cisplatin-based chemotherapy.DESIGN, SETTING, AND PARTICIPANTS: Classification of a retrospective cohort of 149 patient

Denna doktorsavhandling undersöker samtal om personliga problem i mötet med en specialist i radio. I synnerhet handlar studien om den dynamiska process då förståelse skapas – när upplevelser av personliga bekymmer förklaras och definieras som problem av särskilda slag. Denna meningsskapande process undersöks i detalj så som den utspelar sig i dialoger i radio och mellan programdeltagare och radiolThe dissertation examines how personal troubles are talked about in an encounter with a professional on the public arena of radio broadcasting, where the professional has to meet the challenge of making professional advice not only useful for the person seeking help, but also relevant or interesting for the radio audience. The study explores the dynamic process of shaping an understanding of probl

This is a proposal to organize a session.Description:The rapid development of the technological progress is constantly reshaping the organization of the firm, raising important labour law issues.One of the red treads of this phenomenon is the shifting of the focus from the “activity” performed by the worker, to the “result” obtained.In the past it was not always possible to measure the output prod

The commercial availability of low-cost millimeterwave (mmWave) communication and radar devices is starting to improve the adoption of such technologies in consumer markets, paving the way for large-scale and dense deployments in fifthgeneration (5G)-and-beyond as well as 6G networks. At the same time, pervasive mmWave access will enable device localization and device-free sensing with unprecedent

Popular Abstract in English The concern about pollutant emissions from combustion devices has stimulated the development of modern combustion devices. As one of the major power generation machines, modern gas turbine engine has been designed to run at fuel-lean and premixed mode of combustion in which the combustion temperature is moderate so that NOx emission is low. Combustion in premixed mode rThis thesis deals with the physics of turbulent swirling flows. Large eddy simulation (LES) method is used to investigate the vortex breakdown process, the precessing vortex core (PVC), and the effect of swirl number and flow field configuration on swirling flows. The study is based on an open source CFD code, \textit{OpenFoam}. Turbulent swirling flows are widely used in combustion devices such a

Living in a complex and dynamically changing environment requires accurate and timely behavioural responses that allow for adapting to such changes. Well-developed perceptual systems provide a continuous flow of abundant and up-to-date information on the changes in the environment, and, thereby, allow for tailoring behavioural responses accordingly. However, issuing any behavioral response would n

Genom digitaliseringen har nya skapandeformer introducerats. Sampling är en teknik som innebär att på musikområdet använda, spela in eller kopiera delar av verk för att använda dessa inslag i nya sammanhang. Denna skapandeform väcker intressanta frågeställningar om under vilka omständigheter ett sådant vidareutnyttjande kräver tillstånd från rättighetsägaren. Frågan är mer komplex än vad som kan uThrough the digitalization, new ways of creating music have been introduced. Sampling is one technique where parts of a musical work is used, taped or copied in order to be applied into new contexts. This method give rise to several interesting questions concerning under what circumstances such use demands a permission from the copyright owner. This specific issue is far more complex than one coul

Thesis Purpose: This study explores the major drivers and barriers to eco-innovation in Scandinavian and Finnish furniture companies, examining the influence of company size and age. The findings benefit stakeholders including businesses, policymakers, professionals, investors, and consumers. Theoretical Perspective: This study’s theoretical framework was developed through an exploration of eco-in

Aims/hypothesis: The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes (MD) and mild diabetes with high HDL-cholesterol (MDH). This was t

Anthropogenic changes to the environment expose wildlife to many pollutants. Among these, tropospheric ozone is of global concern and a highly potent pro-oxidant. In addition, human activities include several other implications for wildlife, e.g., changed food availability and changed distribution of pathogens in cities. These co-occurring habitat changes may interact, thereby modulating the physi

Recent years has seen an unprecedented growth in emerging technologies like Additive manufacturing (AM), augmenting the manufacturing capabilities through a multitude of opportunities while also introducing unique constraints, such as support structures, and post-processing requirements. Taking full advantage of the potential of AM demands product designs to be optimised for both opportunities and

On January 1, 2011 the new structural design rules (Eurocode) became valid in Sweden; these rules are common to the entire European Union. The reason for the introduction of the Eurocode is to try and eliminate trade barriers between member states. This thesis aims to show what impact this change from Boverkets structural design rules (BKR) to the Eurocode will have on the dimensioning of shear re

Alla naturligt förekommande grundämnen, med få undantag, har skapats i stjärnors inre. Några av dem har skapats långsamt och kontinuerligt och stora mängder har ansamlats under årmiljonerna. Andra har skapats under några få sekunder i några av de mest våldsamma explosionerna i universum, nämligen de s.k. supernovorna. Genom att studera dessa processers avtryck, kan vi fördjupa vår kunskap om, t.exSulphur is one of the more interesting chemical elements from a scientific perspective. As a volatile element, sulphur could potentially be used as a tracer of galactic properties, such as star-formation rate and initial mass function, in both the Milky Way and beyond. But first its origin and production has to be understood. Knowledge of Galactic chemical evolution of sulphur is therefore vital.

En följd av den nya lagen (2014:307) om straff för penningtvättsbrott har varit att ett flertal myndigheter, i diverse rapporter, riktat kritik mot att det råder brist på rättspraxis avseende straffvärdebedömningar i mål om penningtvättsbrott. Utöver dessa myndighetspublikationer är litteraturen om den straffrättsliga regleringen av penningtvättsbrott knapphändig. Det har därför varit av intresse The novel Act regarding penalties for money laundering offences (2014:307) has been criticized by a number of authorities. This, due to the fact that judicial precedent about penal assessment in cases of money laundering offence is scarce. Furthermore, there is a lack of evidence in the literature concerning the new legislation. Therefore, it has been interesting as a part of my essay to study how

On July 8, 2013, the United States and the European Union started negotiations for the Transatlantic Trade and Investment Partnership (TTIP). The TTIP is a proposed international trade and investment agreement (IIA) that aims to create the largest free trade area in the world. Despite the promises of the TTIP, including job opportunities and economic gains of over €100 billion in the EU alone, the