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In type 1 diabetes, pancreatic beta cells are destroyed by chronic autoimmune responses. The disease develops in genetically susceptible individuals, but a role for environmental factors has been postulated. Viral infections have long been considered as candidates for environmental triggers but, given the lack of evidence for an acute, widespread, cytopathic effect in the pancreas in type 1 diabet
Objective: To determine whether a novel therapy for placental insufficiency could achieve orphan drug status by estimating the annual incidence of placental insufficiency, defined as an estimated fetal weight below the 10th centile in the presence of abnormal umbilical artery Doppler velocimetry, per 10 000 European Union (EU) population as part of an application for European Medicines Agency (EMA
Aims. We aim to measure lifetimes of levels belonging to the 3d 3 ( 4 F)4d subconfiguration in Va II, and derive a
Regional climate and energy planning in Sweden has long been fairly weak. Starting in 2008, however, the regional administrative level was strengthened, when the County Administrative Boards (CABs) were commissioned to develop regional climate and energy strategies. Coordinating and involving various stakeholders in the strategy work was essential to the assignment. The process of developing these
Background: Astrocytes produce and store the energy reserve glycogen. However, abnormal large glycogen units accumulate if the production or degradation of glycogen is disturbed, a finding often seen in patients with Alzheimer's disease (AD). We have shown increased activity of glycogen degrading α-amylase in AD patients and α-amylase positive glial cells adjacent to AD characteristic amyloid-β (A
In light of the changing circumstances for teaching, teachers’ views on organizational communication processes were explored. Empirically, this paper is based on five semi-structured focus groups, each interviewed on two occasions. In total, 44 primary and lower secondary-school teachers working in one municipality in Sweden participated. The interviews were framed by a pre-survey concerning demog
In this study, we investigate the molecular structural characteristics of organic remains in various cellular organelles from a 180 Ma Jurassic royal fern belonging to the Osmundaceae family of ferns, and compare their carbon isotopic compositions to a now-living species of royal fern (Osmunda regalis). We discovered molecular structural va
The role of raw plantain flour (RPF) and its citric acid (CA)-esterified counterpart (EPF) on the carbohydrate nutritional properties of cookies was investigated. Cookies were elaborated with commercial wheat flour (CWF), RPF, EPF, or a CWF-EPF blend, and assessed for composition, starch digestibility, texture and sensory properties. EPF-cookie showed the lowest digestible starch (DS) content and
A package written in C for identifying variable dependencies in tables of data is presented. The key ingredient is the δ-test, which establishes dependency structures by exploiting the properties of continuous functions using conditional probabilities formed out of the data. The method estimates most relevant variables, embedding dimensions and noise levels. The program, which is self-contained, a
Background: Calcium overload is a major cause of reperfusion myocardial injury. Multidetector computed tomography (MDCT) has been previously used in visualizing coronary artery calcium, but not calcium deposits in reperfused infarction. Purpose: To assess the ability of MDCT to 1) noninvasively visualize and characterize calcium deposits in reperfused infarcts, and 2) monitor regional wall swellin
This paper deals with a certain type of C.L.T. (Cross Laminated Timber) construction, in a residential building in Fristad, Sweden. The objective is to study impact noise transmission, at the lower frequency range (10-200 Hz), where wooden dwellings perform inefficiently, in terms of acoustic quality. The vibrational behavior of lightweight structures and specifically a multilayered floor separati
The project "Silent Timber Build" will develop new prediction tools for timber structures. There are several challenges that have to be overcome to provide a full prediction tool. The differences in weight, stiffness and density for wooden structures compared to traditional, heavy and more homogeneous structural material have repercussions on how the sound propagates throughout the structures, aff
The authors analyzed the relationship between treatment, local recurrence, and metastases in a population‐based series of 375 patients with soft tissue sarcoma of the extremities and the trunk wall. Treatment was inadequate (marginal excision alone) in 107 patients, local recurrence occurred in 112, and 128 patients developed metastases. Local recurrence was 3.5 times more common after inadequate
A novel method for QRST cancellation during atrial fibrillation (AF) is introduced for use in recordings with two or more leads. The method is based on an echo state neural network (ESN) which estimates the time-varying, nonlinear transfer function between two leads, one lead with atrial activity and another lead without, for the purpose of canceling ventricular activity. The performance is evalua
