Filtyp
The majority of acute coronary syndromes are caused by plaque ruptures. Proteases secreted by macrophages play an important role in plaque ruptures by degrading extracellular matrix proteins in the fibrous cap. Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied.
Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glu
Background Preventive measures are needed to counteract the increasing burden of cutaneous malignant melanoma (CMM). As a basis for rational melanoma prevention, we investigated geographic differences and impact from socioeconomic factors related to incidence, clinical stage at diagnosis and outcome. Material and methods All patients with primary invasive CMM diagnosed in 2004-2013 in the southern
OBJECTIVES: The soluble epoxide hydrolase (gene name EPHX2) is responsible for metabolism of 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in prev
We have investigated the effects of short-term neoadjuvant and long-term androgen deprivation therapies (ADTs) on beta-microseminoprotein (MSMB) and cysteine-rich secretory protein-3 (CRISP3) expression in prostate cancer patients. We also studied if MSMB expression was related to genotype and epigenetic silencing. Using an Affymetrix cDNA microarray analysis, we investigated the expression of MSM
Den internationella organisationen OECD har tagit fram en omfattande åtgärdsplan, BEPS-projektet, som har till syfte att förhindra att nationella skattebaser eroderas på grund av att internationellt verksamma bolag allokerar beskattningsbara vinster till länder med låga skattesatser. Gränsöverskridande koncerninterna transaktioner är en dominerande metod för att åstadkomma önskad vinstallokering. The international organization OECD has developed a comprehensive action plan, the BEPS project, which aims to prevent national tax bases to erode due to that multinational companies allocate taxable profits in countries with low tax rates. Cross-border intra-group transactions is a predominant method to achieve the desired profit allocation. Transfer pricing rules are therefore a central part of
Denna uppsats handlar om en princip som vuxit fram inom folkrätten de senaste decennierna, kallad Responsibility to protect (R2P). Den är en undantagsregel till suveränitetsprincipen och innebär i korthet att om en stat inte kan eller vill skydda sin befolkning från vissa specifikt stadgade brott, har den internationella gemenskapen en möjlighet att intervenera i ett land, utan landets tillstånd. This essay is about a principle in international law that has emerged in the last decades, called Responsibility to protect (R2P). It constitutes an exception to state sovereignty. In short, if a state is unable or unwilling to protect its citizens from some specific crimes, the international community is given an opportunity to intervene in that state without the state’s consent. The Chinese gov
Människor kan utveckla betydande och långvariga relationer till varumärken för att hantera känslomässig ensamhet. Dessa varumärkesrelationer kan liknas vid interpersonella relationer eftersom det uppstår liknande emotionella band mellan parterna. Människor kan även använda varumärken för självuttryck vilket i sin tur kan skapa en tillhörighet till andra människor. Till följd av de förändrade levna
Problembeskrivning: Bearbetade grönsaker kan vara problematiskt då grönsakens förmåga att hålla vatten och näringsämnen förändras med tiden. Det naturliga skyddet mot angrepp från mikroorganismer skadas även det. När man skär eller skadar grönsaker på något sätt så öppnas fler ytor upp för mikroorganismer att ta sig in på och hitta näring för att föröka sig. Men det är inte den enda nackdelen med
Aggressiv skatteplanering har i takt med den digitala ekonomin blivit alltmer vanligt. På grund av multinationella företags globala natur har dessa en fördel i skattehänseenden genom att de kan flytta vinster mellan länder i syfte att betala mindre skatt. Både inom OECD och EU pågår ett ständigt arbete med att minska den aggressiva skatteplaneringen globalt. Genom BEPS-projektet har ett par verktyIn the more digital economy aggressive tax planning has become increasingly common. Due to their global nature, multinational corporations can move profits between countries in order to reduce their taxes. Both the OECD and the EU are continuously working to reduce the aggressive tax planning globally. Through the BEPS project several tools have been developed. One of these is country-by-country-r
Livsmedelsindustrin har stor miljömässig påverkan och uppfyller inte de krav som ställs för att industrin ska betraktas som hållbar. Konsumenterna är en av de viktigaste intressenterna för att kunna implementera hållbar konsumtion. Genom att studera och analysera hur konsumenter skapar värde fås ökad förståelse för vad som driver hållbar konsumtion i livsmedelsindustrin ur konsumentperspektivet. S
The genetic background of Growth Hormone (GH) secretion is not well understood. Mutations giving rise to a stop codon have a high likelihood of affecting protein function.
It has been proposed that vascular progenitor cells play an important role in vascular repair, but their possible clinical importance in cardiovascular disease has not been fully characterized. Vascular endothelial growth factor A, placental growth factor and stem cell factor (SCF) are three growth factors that are important in recruiting vascular progenitor cells. In this study, we investigated t
Background: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. Methods: The GSM of the ca
The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number variants in all KLK genes using quantitative PCR analysis and analysis of inheritance patterns of single nucleotide polymorphisms. Two deletions were identified: one 2235-bp deletion
A major problem when studying behavior and migration of small organisms is that many of the questions addressed for larger animals are not possible to formulate due to constraints on tracking smaller animals. In aquatic ecosystems, this problem is particularly problematic for zoo- and phytoplankton, since tracking devices are too heavy to allow the organism to act naturally. However, recent advanc
Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, pigmentation, proliferative and normal-like), which are predictive of survival outcome as well as informative of biology. Herein, we employed a population-based metastatic melan
OBJECTIVES: To describe the prevalence of cardiovascular disease (CVD) at the time of diagnosis of adult-onset type 1 (T1D) and type 2 (T2D) diabetes, in a recent cohort and compare to a previous cohort from the same region. Further, to explore factors influencing the prevalence of pre-existing CVD, including age, sex, body mass index (BMI) and C-peptide; in the later cohort also heart failure, hy
Land use change and health: A case study of fish farming impacts on malaria prevalence in Kabale district, Uganda. Thesis submitted in partial fulfilment of the requirements for the Master of Science degree in Environmental Studies and Sustainability Science (LUMES) By Kiirya David dlavinco@yahoo.com Supervisor: Dr. Nicodemus Mandere, PhD Lund University Centre for Sustainability Studies (LUCSUS)
https://www.lumes.lu.se/sites/lumes.lu.se/files/kiirya_david_thesis_2011.pdf - 2026-05-30
