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Changes of cellular metabolism are an integral property of the malignant potential of most cancer cells. Already in the 1930s, Otto Warburg observed that tumor cells preferably utilize glycolysis and lactate fermentation for energy production, rather than the mitochondrial oxidative phosphorylation dominating in normal cells, a phenomenon today known as the Warburg effect. Even though many tumor t
The stoichiometries and stability constants of a series of Al(3+)-N-phosponomethyl glycine (PMG/H(3)L) complexes have been determined in acidic aqueous solution using a combination of precise potentiometric titration data, quantitative (27)Al and (31)P NMR spectra, ATR-FTIR spectrum and ESI-MS measurements (0.6 M NaCl, 25 degrees C). Besides the mononuclear AlH(2)L(2+), Al(H(2)L)(HL), Al(HL)(2)(-)
Neuromodulators, such as serotonin (5-hydroxytryptamine, 5-HT) and noradrenalin, play an essential role in regulating the motor and sensory functions in the spinal cord. We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spi
Abstract in ArabicThis report is the primary outcome from Part II of the project “An extended producer responsibility (EPR) system and new business models to increase reuse and recycling of textiles in the Nordic region” initiated by the Nordic waste group (NAG). The full project – comprising Part I and II – is part of the Nordic Prime Minister’s green growth initiative, The Nordic Region – leadin
Background: We found marked improvement of glycemic control and several cardiovascular risk factors in patients with type 2 diabetes given advice to follow a Paleolithic diet, as compared to a diabetes diet. We now report findings on subjective ratings of satiety at meal times and participants' other experiences of the two diets from the same study. Methods: In a randomized cross-over study, 13 pa
Background: Cadmium (Cd), lead (Pb), and mercury (Hg) cause toxicological renal effects, but the clinical relevance at low-level exposures in general populations is unclear. The objective of this study is to assess the risk of developing end-stage renal disease in relation to Cd, Pb, and Hg exposure. Methods: A total of 118 cases who later in life developed end-stage renal disease, and 378 matched
Objectives To determine the effect of an ultrasound training course on the performance of pattern recognition when used by less experienced examiners and to compare the performance of pattern recognition, a logistic regression model and a scoring system to estimate the risk of malignancy between examiners with different levels of experience. Methods Using ultrasound images of selected adnexal mass
This article focuses on the perception of creativity found in copyright law, which conflicts with the ways in which creativity seems to develop in daily practice; the idea of a “solitary genius” is, thus, contrasted to that of a contextually and culturally dependent creator. Copyright is arguably too focused on the former image and fails to acknowledge or embrace the latter. In addition, the digit
The ability to express phenotypically plastic responses to environmental cues might be adaptive in changing environments. We studied phenotypic plasticity in mating behaviour as a response to population density and adult sex ratio in a freshwater isopod (Asellus aquaticus). A. aquaticus has recently diverged into two distinct ecotypes, inhabiting different lake habitats (reed Phragmites australis
Popular AbstractAvhandlingen undersöker sociokulturell och lingvistisk utveckling i det förkolumbianska Amazonområdet, med särskild fokus på perioden 500 f.Kr. till år 1500. Genom att sammanföra och analysera data från arkeologi, lingvistik, etnohistoria, etnografi och geografi i ett Geografiskt Informationssystem (G.I.S.) syntetiserar den stora mängder empiriska data från flera fält för att underThis thesis investigates the socio-cultural and linguistic development of pre-Columbian Amazonia, with a particular focus on the period between 500 BC and AD 1500. In assembling and analyzing data from archaeology, linguistics, ethnohistory, ethnography, and geography in a Geographical Information System (G.I.S.), it synthesizes large amounts of empirical data from several fields to facilitate lon
We present a novel algorithm combined with computational modeling to simulate the development of knee osteoarthritis. The degeneration algorithm was based on excessive and cumulatively accumulated stresses within knee joint cartilage during physiological gait loading. In the algorithm, the collagen network stiffness of cartilage was reduced iteratively if excessive maximum principal stresses were
Wnt5a, a member of non-canonical wingless-related MMTV integration site family is a secreted glycoprotein that plays important roles in development and disease. Recent studies have shown that Wnt5a protein levels are up-regulated in prostate cancer, but contrasting reports exist on the role of Wnt5a to predict outcome after radical prostatectomy in patients with localized prostate cancer. Our grou
CONTEXT The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear. OBJECTIVE To investigate the relationships between lifestyle and health with reproductive hormones in aging men. DESIGN Baseline cross-sectional survey on 3200 community - dwelling men aged 40 - 79 yr from a prospective cohort study in 8 European countries. RESULTS Four predictors we
En ökande användning av ammonium genom samhälls- och industriell utveckling hotar utvatten runt om i världen. För att skydda det akvatiska ekosystemet och dricksvattenresurserna kan ammonium avlägsnas med biologisk behandling vid avloppsreningsverk. Utvecklingen av avloppsreningsverk under det senaste århundradet syftar till att implementera lösningar som är kostnads- och energieffektiva, har en lAn increasing usage of ammonium through societal and industrial development is threatening the water bodies around the world. To protect the aquatic ecosystem and drinking water resources, ammonium can be removed with biological treatment at wastewater treatment plants (WWTP). The development of WWTPs in the last century is aiming to implement solutions, which are cost and energy efficient, have a
Uppsatsen handlar om en oklarhet i rätten till självförsvar enligt FN-stadgan, nämligen när en väpnad attack utförd av en grupp som inte är en del av en stats reguljära armé ändå kan vara hänförbar till den staten ge-nom internationella hänförbarhetsregler. Den relevanta rätten för att avgöra om en väpnad attack är hänförbar till en stat är FN-stadgan, ARSIWA, och internationella domstolars rättsThis essay aims to clear up the obscurity of the right to self-defense in the Charter of the United Nations, and more precisely when an armed attack committed by a group that is not part of a state’s regular army is attributa-ble to the state in question by the rules of attribution in international law. The relevant legal sources for deciding whether an armed attack committed by a group is attrib
Lagen (1988:609) om målsägandebiträde, vilken medger en rätt till biträde för brottsoffer som utsatts för särskilt allvarlig brottslighet, har varit en central lagstiftning för att stärka brottsoffrets intressen i rättsprocessen. Till följd av en lagreform som genomfördes år 2018 har dock rätten begränsats i högre rätt. Detta har i sin tur mötts av omfattande kritik med hänsyn till brottsoffrens iThe Act (1988:609) on Counsel for Injured Parties, which grants the right to counsel for victims of particularly serious crimes, has been a significant piece of legislation for strengthening the interests and rights of crime victims within the legal process. However, a legal reform enacted in 2018 has limited this right in higher courts. This has been met with extensive criticism concerning the in
Många företag verkar idag i globala och ofta mycket komplexa värdekedjor; vägen från råmaterial till färdig produkt kan korsa flera kontinenter, ibland många gånger. Dessa värdekedjor uppmärksammas allt oftare som hem åt omfattande människorättskränkningar, däribland mot arbetare. Med anledning av detta har flera initiativ tagits de senaste åren, både i Europa och internationellt, som syftar till Many modern-day businesses operate in global and highly complex value chains; the journey from raw material to finished product can span multiple continents, sometimes numerous times. These global value chains are increasingly being recognized as home to extensive human rights abuses, including against workers. To address this, several initiatives have been introduced in recent years, both in Euro
Ensuring close control of critical quality attributes (CQAs), such as post-translational modifications (PTMs), in therapeutic monoclonal antibodies (mAbs) is essential for maintaining function and batch homogeneity in large-scale production. Common PTMs include deamidation, fragmentation, oxidation, charge variants, and glycosylations. This study aimed to evaluate CQA variations and correlate the
This paper investigates the intricacies of language complexity in political discourse within the Swedish parliament, with a focus on understanding the impact of mediatization. Drawing on Strömbäck's four-phase framework of mediatization, the study examines whether the internalization of media logic has led to a simplification of language in parliamentary debates. Using a quantitative approach,
Purpose: This paper aims to determine if the relationship between R&D and future firm performance changes once there is a shift in technology. Methodology: Econometric inference, Pooled OLS, hypothesis testing. Empirical foundation: Sample set comprised of companies within the automotive industry between 2001 and 2016. Conclusion: Positive contribution of R&D on future firm performance,
