Filtyp
Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive
Solar-driven photocatalytic green hydrogen (H2) evolution reaction presents a promising route toward solar-to-chemical fuel conversion. However, its efficiency has been hindered by the desynchronization of fast photogenerated charge carriers and slow surface reaction kinetics. This work introduces a paradigm shift in photocatalyst design by focusing on the synchronization of charge transport and s
Effective electron supply to produce ammonia in photoelectrochemical nitrogen reduction reaction (PEC NRR) remains challenging due to the sluggish multiple proton-coupled electron transfer and unfavorable carrier recombination. Herein, InP quantum dots decorated with sulfur ligands (InP QDs-S2−) bound to MIL-100(Fe) as a benchmark catalyst for PEC NRR is reported. It is found that MIL-100(Fe) can
Background People living with serious respiratory illness experience a high burden of symptoms. This review aimed to determine whether multicomponent services reduce symptoms in people with serious illness related to respiratory disease. Methods Electronic databases were searched to identify randomised controlled trials (RCTs) evaluating multicomponent services that enrolled patients due to sympto
BACKGROUND: A significant proportion of people with migraine do not achieve sufficient relief of their acute migraine symptoms with the currently available medications. A previous study showed that intranasal evaporative cooling reduced headache and migraine-associated symptoms when given in an outpatient clinic setting. This study aimed to evaluate the feasibility of self-administering the same i
Background and aim: It is crucial to identify a diabetes diagnosis early. Create a predictive model utilizing machine learning (ML) to identify new cases of diabetes in primary health care (PHC). Methods: A case-control study utilizing data on PHC visits for sex-, age, and PHC-matched controls. Stochastic gradient boosting was used to construct a model for predicting cases of diabetes based on dia
Background: Optimal anticoagulation management in patients with myeloproliferative neoplasms (MPN) experiencing splanchnic vein thrombosis (SpVT) requires balancing risks of bleeding and recurrent thrombosis. Objectives: We conducted a systematic review and meta-analysis to assess the incidence of bleeding and thrombosis recurrence in patients with MPN-SpVT. Methods: We included retrospective or p
Risk scores play an important role in clinical medicine. With advances in information technology and availability of electronic healthcare record, scoring systems of less commonly seen diseases and population can be developed. The aim of the article is to provide a tutorial on how to develop and validate risk scores based on a virtual dataset by using R software. The dataset we generated including
Open science aims to improve research accessibility, replicability, and consequently its quality. Empirical software engineering entails both data and artifacts, which may be shared more or less openly, to support transparency. However, the trade-offs involved in balancing the openness against integrity and secrecy concerns need methodological guidance. Aim. We aim to derive such advice, based on
In spite of the similar structural and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking differences exist between them in terms of replication dynamics and clinical manifestation of infection. Although the pathomechanism of HIV-1 infection is well characterized, relatively few data are available regarding HIV-2 viral replication and its interaction wi
Student evaluation of teaching (SeT) is ubiquitous in higher education but has been criticized by many scholars because of low use for course improvement benefiting student learning. Academic developers (ADs) are responsible for pedagogical courses and to support leadership and academics in processes enhancing educational quality. We could therefore expect ADs to play a key role in SeT practice. T
In this paper, a goal-oriented error estimation technique for static response sensitivity analysis is proposed based on the constitutive relation error (CRE) estimation for finite element analysis (FEA). Strict upper and lower bounds of various quantities of interest (QoI) that are associated with the response sensitivity derivative fields are acquired. Numerical results are presented to assess th
Carbon nanotubes (CNTs) are promising blocks for building advanced yarns with unique structural and functional attributes. However, the complexity of fabrication and high cost has hindered the widespread adoption of CNT yarns. In this study, a rapid and continuous twisting wet spun yarn strategy to produce highly densified CNT yarns is presented. The method involves effectively dispersing CNTs in
Purpose: Forehead flaps are commonly used in oculoplastic surgery to cover defects after tumor excision. Blood perfusion is vital for flap survival. The aim of this study was to monitor the perfusion in forehead flaps and investigate the impact of flap length and thickness. Methods: Nineteen forehead flaps in patients undergoing direct brow lift were studied. Perfusion was monitored using laser sp
Background: Congestion is associated with poor prognosis in cardiac amyloidosis (CA). The cardio-hepatic interaction and the prognostic impact of secondary liver affection by cardiac congestion in CA are poorly understood and require further characterisation. Methods: Participants of the amyloidosis cohort study AmyKoS at the Interdisciplinary Amyloidosis Centre of Northern Bavaria with proven tra
We tested the chondrogenic potential of demineralized allogeneic bone matrix (DABM) in the repair of osteochondral defects. In 42 adult rabbits, a 5-mm2 or 15-mm2 defect was created bilaterally in the intercondylar groove of distal femur. DABM was inserted directly in 37 defects, whereas in 35 it was inserted after previous placement in muscle for 4, 16, or 19 days. Another 12 defects were left em
Here we present a new eastern Baltic Chironomidae training set (TS) containing 35 sites that was collected and merged with neighbouring published Finnish (82 lakes) and northern part of the Polish (nine lakes) TSs. Chironomidae, non-biting midges, are known to be strongly responsive to the July air temperature and are widely used to infer palaeotemperature. Several modern analogue-based TSs necess
Winter warming events (WWEs) are short-lasting events of unusually warm weather, occasionally combined with rainfall, which can cause severe ecosystem impacts by altering ground temperatures and water fluxes. Despite their importance, how large-scale ecosystem models perform in depicting the impacts of WWEs remain largely unknown. The frequency and intensity of WWEs will likely increase further in
Background: Employment is a vital source for experiencing well-being and lowering the risk of long-term social marginalisation and poverty. For persons with alcohol and drug addiction, it may also improve sobriety. However, the unemployment situation for this group reflects the knowledge gap in effective interventions to support employment. While Individual Placement and Support (IPS) is recognise
