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Background As new product development is becoming more important due to higher and more global competition the new product introduction process needs to be efficient in order to launch new products before they become obsolete. Therefore, a more efficient development process with integrated functions is needed. Concurrent engineering claims to be this and has support in much research. However, conc
Energy sufficiency has been recognised as a strategy to promote sustainable energy use and achieve climate neutrality. It aims to reduce energy demand in absolute terms. ‘Living Space Reduction’ (LSR) is one way to achieve energy sufficiency in the housing sector. However, existing studies highlight significant barriers to its materialisation, including the lack of funding and expert knowledge of
Cancer cell detection by particle sorting systems is a very challenging field which could help to discover cancers at an earlier stage. Acoustophoresis used as a particle sorting system is based on the difference between the acoustic properties of particles and the medium. Using a standing acoustic wave, the particles with the equivalent acoustic properties are focused at the same point in the cha
Addressing electronic waste is crucial for meeting the environmental needs of the 21st Century, as WEEE is one of the fastest growing waste streams. Spain has emerged as one of the top countries globally for per capita mobile phone consumption. For this reason, this thesis focuses on European and Spanish initiatives that am to improve the circularity of mobile phones through repair. In recent year
The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage
To reduce the risk of serious chemical accidents to occur there is a legislation called the Seveso-legislation. One part of this legislation demands that all business that handle certain amounts of chemical compounds to submit a safety report in order to get permission to run their business. The safety report should contain over-all plans of how to handle safety as well as detailed descriptions o
Syfte: Det som uppsatsen vill klarlägga är hur företag sätter sina diskonteringsräntor, om det finns korrelation mellan bolagens verkliga resultat och/eller goodwillpostens relativa storlek och om detta beror på opportunistiskt tänkande i bestämmandet av denna ganska väsentliga parameter. Metod: Med syftet som utgångspunkt har en kvantitativ metod valts. Data har samlats in från främst företagensPurpose: The paper sets out to research how companies determine their discount rate, if there’s correlation between companies’ profitability and/or the goodwill relative size and if it therefore can be established if there’s an opportunistic way of thinking when choosing the discount rate. Methodology: With the purpose as a starting point, a quantitative method has been chosen. Data has been gat
Public transportation gets paralyzed every year when winter conditions occur and the purpose of this thesis has been to summarize experiences from tram cities, mainly in Scandinavia, and suggest solutions to the problems identified. Material was collected from Stockholm, Gothenburg, Norrköping, Oslo, Trondheim, Helsinki and Budapest. Operating the tramway during winter leads to problems specific t
The Öresund Region, comprising areas of Sweden and Denmark, is involved in a process of sustainable urban transformation. The region has high ambitions in terms of carbon emissions reduction and has set itself steep targets to meet over the next 15-20 years. The energy consumption of buildings accounts for a significant proportion of carbon emissions. With the urban areas of the Öresund Region exp
Our aim for this essay was to examine, with the method of a discourse analysis, how the best interest of the child is constructed in the political debate on the issue of single women’s right to use artificial insemination. The questions we asked ourselves were: Where do the political parties stand on the issue of single women’s right to use artificial insemination? How is the best interest of the
OBJECTIVE In type 2 diabetes, insulin resistance and progressive b-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic control compared with an isocal
Myxoinflammatory fibroblastic sarcoma (MIFS) has recurrent genetic features in the form of a translocation t(1;10)(p22-31;q24-25), BRAF gene fusions, and/or an amplicon in 3p11-12 including the VGLL3 gene. The breakpoints on chromosomes 1 and 10 in the t(1;10) cluster in or near the TGFBR3 and OGA genes, respectively. We here used a combination of deep sequencing of the genome (WGS), captured sequ
Background: Physical and biological properties of dust particles might affect the availability and distribution of chemicals associated to indoor dust; however it has not been adequately examined. In this study, household dust from Shanghai was fractionated into five particle sizes and size distribution, morphology, surface area, organic matter, microorganisms, elemental composition, metals and or
OBJECTIVE: A randomized controlled trial (RCT) was undertaken to determine the effect of negative pressure wound therapy (NPWT) on closed incisions after inguinal vascular surgery regarding surgical site infections (SSIs) and other wound complications. BACKGROUND: SSIs are a major concern in open vascular procedures involving the inguinal region. Prophylactic NPWT on closed incisions has shown pro
The incidence of FIX inhibitors in severe hemophilia B (SHB) is not well defined. Frequencies of 3-5% have been reported but most studies to date were small, including patients with different severities, and without prospective follow-up for inhibitor incidence. Study objective was to investigate inhibitor incidence in patients with SHB followed up to 500 exposure days (ED), the frequency of aller
Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children
