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BACKGROUND AND AIMS: The severity of the atherosclerotic burden is hardly quantifiable in subjects at high cardiovascular (CV) risk under intensive pharmacological therapy. Several molecules have been proposed as circulating biomarkers of atherosclerosis, but none has emerged as clinically meaningful.METHODS: Circulating proteins involved in inflammation, plaque remodeling, smooth muscle cell migr
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of bloo
AimsOrthostatic hypotension (OH) is an important differential diagnosis in unexplained syncope. Neurogenic OH (nOH) has been postulated to differ from non-neurogenic OH (non-nOH), yet pathophysiological differences are largely unexplored. We aimed to investigate aetiology and tilt table test (TTT)-induced haemodynamic responses in symptomatic OH patients.Methods and resultsWe performed a retrospec
BACKGROUND: Previous post hoc analyses of clinical trials have suggested that a higher percentage of systolic blood pressure time in target range (SBP-TTR) was associated with a decreased risk of cardiovascular disease (CVD). However, there is limited evidence from large prospective cohort studies on the relationship between long-term SBP-TTR and the risk of CVD.OBJECTIVES: The purpose of this stu
OBJECTIVE: This study investigated trajectories of patient acceptable symptom state (PASS) among participants of a digital education and exercise therapy for knee and hip osteoarthritis.METHODS: A longitudinal observational study among individuals aged 40+ years who participated in the digital program. Participants completed PASS (yes/no) at enrolment and at least one follow-up during one year aft
Objective: To evaluate the causal effect of genetically predicted serum urate (SU) levels on the risk of overall and major site-specific cancers in individuals of European ancestry, using Mendelian randomization (MR) analysis. Method: Data from two population-based cohorts from southern Sweden, the Malmö Diet and Cancer Study (MDCS) and Malmö Preventive Project (MPP), and summary-statistics data f
GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in
BackgroundProenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been proposed as an early indicator of acute kidney injury (AKI) although its performance is dependent on the clinical setting. This meta-analysis aimed to investigate the correlation between PENK levels and the development of AKI.Methods
Background: About one in ten adults are living with diabetes worldwide. Intake of carbohydrates and carbohydrate-rich foods are often identified as modifiable risk factors for incident type 2 diabetes. However, strong correlation between food variables can make it difficult to identify true associations. The purpose of this study was to identify clusters of carbohydrate-rich foods and analyse thei
High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals)
Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years. Methods: A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Pr
Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimat
Knowledge of how biodiversity sustains ecosystem function comes predominantly from studies focused on small spatial scales. Thus, we know relatively little about the role of biodiversity at larger scales of space and time where habitats become increasingly heterogeneous. Efforts to upscale the relationship between biodiversity and function have yielded inconclusive results. Given that increasing h
Målformulering: Examensarbetet primära mål är att påvisa att de byggentreprenörer som arbetar med BIM bidrar till ett effektivare arbetssätt och ekonomiskt mervärde. Detta genom att visa att en fundamental BIM-nytta såsom mängdavtagning är en ekonomisk vinning. Syfte: Syftet är att påvisa attmängdavtagningav väggar, bärande samt rumsbildande, inklusive dörrar och fönster via BIM är ett ekonomisktPurpose: The primary purpose is to demonstrate that constructors, which use BIM, contributes to a more efficient work and economic value to the process of construction projects. This, by showing that a fundamental use of BIM in "quantity take-off” is a financial gain. Furthermore, the study aims to evaluate how projects affected by the extent of BIM-use is in current situation. Additionally,
Mer information och instruktioner för ansökan ETP förklarande Meriterad lärare, excellenta lärare och pedagogisk akademi Bakgrund Medicinska fakulteten beslutade 2008 att inrätta en pedagogisk akademi. Genom denna skulle det pedagogiska uppdraget för fakultetens lärare tydliggöras, den pedagogiska verksamheten bli mer utåtriktad, speciellt förtjänstfulla lärare uppmärksammas och deras erfarenheter
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Uppdragsavtal PAGE 5(5) This template regulates the conditions for the employment of an externally employed doctoral student. If there is to be a collaboration project between LU and the Company, this is to be regulated in a separate collaboration agreement. Agreement on Financing of Externally Employed Doctoral Students Between Lund University , Department of …….. , hereafter referred to as LU, a
Institutionen för kulturvetenskaper, Idé- och lärdomshistoria LITTERATURLISTA 2 Sida 3 av 2 Kurslitteratur för ILHS20, Vetenskap, kultur och samhälle (7,5 hp), VT 2026 Fastställd 2025-12-04 Litteraturen är tillgänglig via FINN. Obligatorisk litteratur Agar, Jon, 2008. ”What Happened in the Sixties?”, The British Journal for the History of Science , 41(4): 567-600. (34 s.) Amsterdamska, Olga, 2005.
