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Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life. Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less. Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this internat

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This paper discusses the role of fundamental rights in the EU’s legislation on digitalisation, with a particular focus on the proposed Digital Services Act (DSA) and the Digital Markets Act (DMA). As the EU Charter of Fundamental Rights is receiving an increasingly prominent role in regulating the digital sphere in order to rectify the increasing challenges of a ‘wild West’ internet, the constitut

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BACKGROUND: Early palliative care provides better quality of life, increased prognostic awareness, and even improved survival for patients with advanced cancer but how the integrated care model achieves these outcomes has not been completely explained.METHODS: To better understand the clinical approach to early outpatient care from the clinicians' perspective, we conducted focus groups with the pa

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Statistics reveal the concerning prevalence of mental health issues among Swedish public sector managers, highlighting the critical need for deeper insights into the relevance of social support in coping with work-related stress. This study aims to examine the relevance of various sources of social support for managers coping with work-related stress, an area relatively underexplored in public adm

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Selecting the most suitable procurement strategy is crucial to the efficient management of supply chain operations and the prevention of stock shortages. Nevertheless, when dealing with a wide variety of products, this task becomes an intricate challenge. While traditional and advanced procurement tools are available, applying them across such diverse product ranges is often impractical. This rese

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Background Transcatheter aortic valve implantation (TAVI) is an increasingly important treatment option for patients with severe aortic stenosis. Its best implementation is debated, as few centres with high volumes are associated with better outcomes, while centralization might lead to an inferior availability of treatment for patients living far away. The aim of this study was to investigate the

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The S-scheme mechanism in photocatalysis offers a promising approach to significantly enhance photoreductive activity. Here, using Bi dots as electronic media, and by changing the amount of added C@CuO on the surface of flower-shaped Bi2MoO6, a diverse range of CBM-x heterojunctions, were synthesized using a multi-step approach that incorporated solvothermal preparation and calcination methods. CB

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Background: Telemedicine innovations are rarely adopted into routine health care, the reasons for which are not well understood. Teleguidance, a promising service for remote surgical guidance during endoscopic retrograde cholangiopancreatography (ERCP) was due to be scaled up, but there were concerns that user attitudes might influence adoption. Objective: Our objective was to gain a deeper unders

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The major seminal vesicle secreted proteins in human semen, semenogelin I and semenogelin II, interact non-covalently and via disulphide bridges to instantly form a coagulum upon ejaculation. The coagulum is liquefied after a few minutes due to the action of a prostatic serine protease, prostate-specific antigen (PSA). In contrast to rat semen, which forms an insoluble plug within minutes of expul

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A growing body of studies emphasizes the discovery of opportunities and the decision to exploit them as the essence of entrepreneurial activity. Following this stream of research, we present a study of the influence of entrepreneurs’ career experience and career motives on two alternative modes of decision making logic; causation and effectuation. Causal reasoning is a process that rests on logic

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A search for heavy Majorana neutrinos in events containing a pair of high-p(T) leptons of the same charge and high-p(T) jets is presented. The search uses 20.3 fb(-1) of pp collision data collected with the ATLAS detector at the CERN Large Hadron Collider with a centre-of-mass energy of root s = 8TeV. The data are found to be consistent with the background-only hypothesis based on the Standard Mod

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Induction and regulation of specific intestinal IgA responses critically depend on dendritic cell subsets and the T cells they activate in the Peyer's patches (PP). We found that oral immunization with cholera toxin (CT) as an adjuvant resulted in migration-dependent changes in the composition and localization of PP DC subsets with increased numbers of CD103 - cDC2s and LysoDCs in the subepithelia

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The main objective of this paper is to develop a readiness index model that can serve as an analytical tool for exploring the achievements of the electrification of transportation systems. We have applied this readiness index model to evaluate the readiness positioning of China, Norway, and Sweden towards transportation electrification. We have chosen these three countries as they represent divers