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Popular Abstract in Swedish Information om smärta, klåda och temperaturförändringar förmedlas till centrala nervsystemet av tunna nervfibrer som leder nervimpulser relativt långsamt. Information om beröring av huden förmedlas istället av grova och snabbt ledande nervfibrer. Det är välkänt att olika känselkvaliteter kan interagera med varandra på olika nivåer i centrala nervsystemet. Vanlig berörinIt is known that stimulation of thin nerve afferents can inhibit itch and pain and that the nociceptive systems have a detailed topographical organisation, with subsystems exhibiting specific excitatory and inhibitory receptive fields. On this basis, a new technique was developed, termed Cutaneous Field Stimulation (CFS), that electrically stimulates thin nerve fibers innervating specific skin fie

This study uses the Swedish register of prescribed drugs, merged with the Survey of Living Conditions (the ULF), to analyze the socioeconomic gradient in drug utilization. It finds a significant education gradient (but no income gradient) in individual drug utilization. Whereas the education gradient for men is quantitative in its orientation (education affects number of drugs used), the gradient

Chondroitin (CS) and dermatan sulphate (DS) are socalled glycosaminoglycans (GAG) that are covalently attached to various type of proteins forming a subgroup within the diverse proteoglycan (PG) family. The PGs studied in this thesis are mostly extracellularly located and include aggrecan, biglycan and decorin. The CS and DS chains both consist of repeating disaccharides of the type (hexuronic aci

A strategy for feedback control of the glucose feed rate in cultivations of E.coli is discussed. By making probing pulses in the feedrate it is possible to detect and avoid undesirable by-productformation using a standard dissolved oxygen sensor. The feasibility of an improved and simplified probing algorithm is demonstrated by simulations as well as laboratory-scale experiments.

This thesis explores the conditions to improve collaborative behaviour between organizations in crisis response management. It takes an explorative approach and begins by identifying several challenges to interorganizational collaboration. A systematic review of the international scientific literature in conjuction with semi-structured interviews with crisis management professionals in civil-milit

This thesis is a comparative study of the communist past as depicted in Czech and German feature films since 1989, or ‘reel socialism’. It is the first detailed study of post-1989 Czech history films and the first comparative study of German post-reunification cinema. It demonstrates that cinema has been a vehicle of similar sense-making processes in the two history cultures. Much of the research

The combination of graphical models with Aalen's additive hazards model, resulting in a model known as dynamical path analysis, permits assessing the effects of different variables on times until an event and decomposing these total effects into direct and indirect effects. This thesis proposes novel bootstrapping methods designed for left-truncated right-censored data, conditional on covariat

This thesis seeks to investigate the structural circumstances regarding the poor refugee protection for Burmese refugees in Thailand. Acknowledging that existing laws are politically motivated, the first part of this thesis examines the political context that determines the structure of the legal framework. The second part of the thesis scrutinizes the juridical framework concerning refugees, name

Denna uppsats undersöker hur EU:s konkurrenslagstiftning reglerar interoperabilitetsskyldigheter för dominerande digitala plattformar. Uppsatsen visar hur EU-domstolens avgörande i Android Auto (C-233/23) omformar teorin om nödvändiga nyttigheter (Essential Facilities Doctrine, EFD) som etablerades i Bronner-domen (C-7/97). Vidare analyseras denna framväxande doktrins samspel med de interoperabiliThis thesis explores how EU competition law governs interoperability obligations for dominant digital platforms. It shows how the CJEU’s judgment in Android Auto (C-233/23) redefines the Essential Facilities Doctrine (EFD) established in Bronner judgment (C-7/97) and how this emerging doctrine interacts with the interoperability obligations introduced by the Digital Markets Act (DMA). The Android

Denna examensuppsats undersöker den rättshistoriska utvecklingen av det svenska statliga detaljhandelsmonopolet för alkohol med fokus på hur inskränkningar i näringsfriheten och köprätten reglerats och motiverats från framförallt 1850-talet fram till idag. Uppsatsen analyserar de bakomliggande politiska resonemangen och hur dessa har skiftat i takt med samhällets förändringar, från tidig moralisk This thesis examines the legal history of the Swedish state monopoly on alcohol retail, focusing on how restrictions on freedom of trade and purchasing rights have been regulated and justified, primarily from the 1850s to the present day. The thesis analyzes the underlying political reasoning and how this has shifted in line with changes in society, from early moral education to modern public heal

This thesis investigates whether integrating technical market data with fundamental accounting variables improves the out-of-sample predictability of stock returns in the highly liquid S&P 100 universe. Using an expanding window approach from 2010 to 2024, the study compares the performance of regularized linear (Ridge Regression) and non-linear (Histogram Gradient Boosting) estimators against

Accurate thermometry is essential for experiments in cryogenic environments, particularly those using dilution refrigeration to reach milli-Kelvin temperatures. In this thesis, the calibration range of a Cernox CX1050 sensor was extended below its nominal lower limit of 1.4 K. In addition, the response of RuOx sensors at different positions within the dilution refrigerator was examined to assess t

The aim of this research is to study three particle correlations in pseudo-rapidity for the $\Lambda^0$,$\Xi^0$, and $\Omega^-$ hyperons with a focus on their baryon and strangeness quantum numbers. The two primary questions asked are, into which particles are these quantum numbers typically conserved, and what are their correlations in momentum space. The research investigates these problems by e

Seriepositionseffekter och recency-kvoten har visat potential som kliniska verktyg riktade mot neurokognitiva störningar, de har dock förblivit outforskade i Claeson-Dahls Test för inlärning och minne (CDT). Den aktuella studien syftade att fylla kunskapsluckan, vilket gjordes genom naturalistiskt insamlade data (N = 110) från ett projekt avsett att uppdatera CDT:s normer. Jag hypotiserade förekomSerial positioning effects and the derived recency ratio has shown increasing promise as clinical tools for evaluating neurocognitive disorders. These measures have remained unexplored in Claeson-Dahl’s Test for verbal learning and retention (CDT). To correct this, the present study used naturalistic sample data (N = 110) from a project intended to update CDT’s norms. I hypothesized the prevalence

There is a need to closer characterise the molecular changes associated with progression from low to high mortality stage cutaneous T cell lymphoma. This has been challenging since there is high inter-patient heterogeneity in the genetics and transcriptomics of the malignant T cell populations. Modern technology has enabled single-cell resolution as well as spatially guided cell selection for whol

Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (IC