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Heteroclitic monoclonal antibodies are characterized by the ability to bind multiple epitopes with little or no similarity. Such antibodies have been reported earlier, but insight into to the molecular basis of this propensity is limited. Here we report that the KIM185 antibody to human CD18 reacts with the plasma protein C4b-binding protein (C4BP). This was revealed during affinity purification p
Contagious yawning has been reported for humans, dogs and several non-human primate species, and associated with empathy in humans and other primates. Still, the function, development and underlying mechanisms of contagious yawning remain unclear. Humans and dogs show a developmental increase in susceptibility to yawn contagion, with children showing an increase around the age of four, when also e
OBJECTIVE-FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO) influences BMI across adult life span. RESEARCH DESIGN AND METHODS-Through regression models, we assessed the relationship between the FTO single nucleotide polymorphisms rs9939609, type 2 diabetes, and BM
Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Background: Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects are poorly described. Methods: Sixty healthy subjects 25 males, 35 females, age 55 to 83 years, body mass index > 25 kg/m(2)) were included in a cross-over study with 5 hours of
The psychometric properties of the Swedish self-report version of the Strengths and Difficulties Questionnaire (SDQ-s), and the prevalence of emotional and behavioral problems as measured by the SDQ-s, were studied in 14 to 15-year-old adolescents. The psychometric properties were found to be similar to those found in other language versions, in terms of similar factor structure and acceptable tes
This study presents data from a molecular survey of the species of the genus Culicoides from the region of Kalimok Field Station (NE Bulgaria) and haemosporidian parasites occurring in them in order to investigate the host-parasite specificity of haemosporidians to their dipteran vectors. The identification of Culicoides spp. was carried out by morphological and molecular-genetic methods. We colle
Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription factor closely related to PU.1 and SPI-B, and expressed temporarily during B-cell
This thesis critically examines ethnicity matching between children awaiting adoption and prospective adopters and its discriminatory consequences for ethnic minority children under the European Convention on Human Rights. The examination is conducted against the background of the adoption controversy, and the differing views on what is in the best interests of the child. It highlights how the Eur
The conventional agricultural production system is not sustainable. Organic agriculture is assumed to be sustainable from the environmental perspective, and its production and labelling has been regulated in the European Union (EU). The EU organic regime has been challenged by proponents of agroecology, a philosophy that merges agriculture and ecology and considers environmental and social aspects
Ukraine is at a cross roads. Several important decisions are needed to be made and carried out in a short time to secure the future of their in many cases broken and inefficient district heating systems (DHS), which heat the homes and offices of millions Ukrainians today. To make matters worse they have foreign interests panting down their necks with demands of payments regarding gas bought and im
This thesis looks at the asylum policy of Turkey, on its path to EU accession. This thesis accepts the hypothesis that a rigid nation state practice is a hindrance to the development of human rights and examines this issue in the context of Turkey. The research question of this thesis asks; is there a possibility to gain decent life conditions for refugees in Turkey? Is the EU membership/accession
The aim of this Master's thesis is to examine the ways in which culture and cultural policy are being articulated in the process of Lund's application to become Sweden's European Cultural Capital of 2014. I have used Dorte Skot-Hansen's three cultural political rationalities: the humanistic-, the sociological- and the instrumental rationality, as well as and Jenny Johannisson'
Context: The dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits glucagon secretion at hyperglycemia but appears to enhance glucagon counterregulation during hypoglycemia in type 2 diabetes.Objective:The objective of the investigation was to study whether vildagliptin also improves α-cell function in type 1 diabetes (T1D). Patients and Methods: The study was a single-center, double-blind, ra
It is shown theoretically that a claim in the literature about the overall separation efficiency of asymmetrical flow FFF channels being improved by geometries that permit a uniform channel flow velocity throughout the channel length is untrue.
Through a comparative analysis of works by street artists Faile and Banksy, from both the street and the gallery, I make the point that the field of modern street art is not as homogenous as the media and the established art world often portray it. By differentiating between sub- and counter-cultural agents, I point out the span of social and ideological backgrounds within the street art culture a
The rights-based approach (RBA) to development is a response to the perception that development aid has largely failed to overcome discriminatory structures and to help the poorest. The RBA aims to empower the powerless and focuses more on the processes in society than on delivering services. In reality however, these intentions are implemented very differently. This thesis analyses how rights-bas
This report describes the differences between a risk analysis and a vulnerability analysis, when applied to a Flue Gas Desulphurisation (FGD) facility. A Preliminary risk analysis complemented by an Event Tree analysis is compared with An App-roach to Vulnerability Analysis of Complex Industrial Systems by Einarsson and Rausand (1998). The focus of this report is to demonstrate the different steps
