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Background. Uraemia increases oxidative stress, plasma titres of antibodies recognizing oxidized low-density lipoprotein (oxLDL) and development of atherosclerosis. Immunization with oxLDL prevents classical, non-uraemic atherosclerosis. We have investigated whether immunization with oxLDL might also prevent uraemia-induced atherosclerosis in apolipoprotein E knockout (apoE-/-) mice. Methods. ApoE
Recent research has shown that agricultural management affects microbial biomass and community composition. We investigated the functional implications of such effects in terms of barley biomass production and nutrient acquisition, and whether changes in barley nutrient status affected aphid fecundity. Soils were collected from conventional, ley and organic arable fields and used as inocula in a g
Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses.
OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 i
This study investigates online material published in reaction to a Science magazine report showing the absence of peer-review and editorial processes in a set of fee-charging open access journals in Biology. Quantitative and qualitative textual analyses are combined to map conceptual relations in these reactions; and to explore how understandings of scholarly communication and publishing relate to
Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SN
Antigen presenting cells (APC) have the ability to present both extra-cellular and intra-cellular antigens via MHC class I molecules to CD8(+) T cells. The cross presentation of extra-cellular antigens is reduced in mice with deficient Antigen Peptide Transporter 1 (TAP1)-dependent MHC class I antigen presentation, and these mice are characterized by a diminished CD8(+) T cell population. We have
A machine-learning and a string-matching approach to automated subject classification of text were compared, as to their performance, advantages and downsides. The former approach was based on an SVM algorithm, while the latter comprised string-matching between a controlled vocabulary and words in the text to be classified. Data collection consisted of a subset from Compendex, classified into six
The volume of fluid (VOF) and immersed boundary (IB) methods are two popular computational techniques for multi-fluid dynamics. To help shed light on the performance of both techniques, we present accuracy assessment, which includes interfacial geometry, detailed and global fluid flow characteristics, and computational robustness. The investigation includes the simulations of a droplet under stati
Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly asso
Objectives. Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis. Design. We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or n
BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.METHODS: We analyzed 64,901 individuals of European ancestry without
Background:Recent cross-sectional genome-wide scans have reported associations of 97 independent loci with body mass index (BMI). In 3541 middle-aged adult participants from the GLACIER Study, we tested whether these loci are associated with 10-year changes in BMI and other cardiometabolic traits (fasting and 2-h glucose, triglycerides, total cholesterol, and systolic and diastolic blood pressures
Aims/hypothesis: Insufficient insulin release and hyperglucagonaemia are culprits in type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART, encoded by Cartpt) affects islet hormone secretion and beta cell survival in vitro in rats, and Cart−/− mice have diminished insulin secretion. We aimed to test if CART is differentially regulated in human type 2 diabetic islets and if CART affe
The purpose of this book chapter is to investigate to what extent technical function can be protected under European Union (EU) copyright law. Technical function has been explicitly excluded under other regimes of protection in the Union, for example, trademark and design protection law, to avoid overlap (also known as cumulation) between these regimes and patent law. No such statutory provisions
Schema, Kandidat (grupp 1-7) och Magister Grupp Datum, lokal Tid Examensstudent Prel.titel på examensarbete 1 Måndag 1 Juni 9.00-9.30 Cecilia Östlund En fallstudie om miljöarbetet på Capio S:t Görans sjukhus akutmottagning Mossen Väster 9.30-10.00 Matilda Öhgren Incitament för energibesparing i studentbostäder Ekologihuset 10.30-11.00 Pontus Sterner Vindkraftens påverkan på torsk under anläggning.
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_kandidat_magister_1_juni.pdf - 2026-07-20
