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It is generally believed that pregnancy is mediated by a Th2 response, which includes cytokines that promote placental growth and are involved in inducing tolerance to the foetus. If the balance between Th1/and Th2-mediated cytokines is disrupted, systemic and local changes could predispose the foetus to future disease. Therefore, a shift in the Th1/Th2 balance during pregnancy, possibly caused by
OBJECTIVES: Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential rol
Adult type 2 diabetes patients with GAD65 autoantibodies (GADA) are known as latent autoimmune diabetes in adults (LADA). It has been suggested that GADA in LADA patients preferentially bind to the N-terminal end of GAD65. Using the N-terminal end extension of (35)S-GAD65 generated by the pEx9 plasmid, we tested the hypothesis that GADA in LADA patients preferentially react with (35)S-GAD65 from t
The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the resp
WPSS ON -a & -at Working Papers in Scandinavian Syntax 100 (2018), 20–40 Revisiting the etymology of the Norse negative enclitic -a/-at1 Eric Lander University of Gothenburg In this paper I present and discuss the etymological hypotheses that have been put forth through the years for Norse -a/-at ‘not’, a negative particle suffixed to finite and imperative verbs, found primarily in Old Icelandic a
https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_grimm/working_papers/2018-jun/Lander.pdf - 2026-07-04
Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD
Background: Epidemiological studies have shown considerable heritability of blood pressure, thus suggesting a role for genetic factors. Previous studies have shown an association of a single nucleotide polymorphism rs5068 in the NPPA locus gene with higher levels of circulating atrial natriuretic peptide as well as with lower intra individual blood pressure, but up to date, no association between
Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic markers measured in multiple studies, based on the analysis of individual participan
Background: Dietary fiber, carbohydrate quality and quantity are associated with mortality risk in the general population. Whether this is also the case among diabetes patients is unknown. Objective: To assess the associations of dietary fiber, glycemic load, glycemic index, carbohydrate, sugar, and starch intake with mortality risk in individuals with diabetes. Methods: This study was a prospecti
Impaired autonomic control of postural homeostasis results in orthostatic intolerance. However, the role of neurohormones in orthostatic intolerance has not been explained.
We take ”better than”, denoted by ≻, as a primitive relation Printed from: Hommage à Wlodek. Philosophical Papers Dedicated to Wlodek Rabinowicz. Ed. T. Rønnow-Rasmussen, B. Petersson, J. Josefsson & D. Egonsson, 2007. www.fil.lu.se/hommageawlodek PARITY DEFINED IN TERMS OF BETTERNESS Erik Carlson Department of Philosophy, Uppsala University Erik.Carlson@filosofi.uu.se ABSTRACT: Ruth Chang has def
https://www.fil.lu.se/hommageawlodek/site/papper/CarlsonErik.pdf - 2026-07-05
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BACKGROUND: Multidrug resistant Acinetobacter baumannii remains a global concern with its ability to adhere, disperse and sustain in areas involving suboptimal infection control measures, particularly in war areas. In this study we aimed to evaluate the susceptibility profiles, molecular epidemiology and pathogenesis of A. baumannii isolates from conflict zones in Ukraine.METHODS: A. baumannii wou
Microsoft Word - Enkätresultat sammanfogad 220224 försättsblad inledning register Resultat Distriktsveterinärföreningens enkät om förutsättningarna och villkoren för vårt yrke Februari 2022 1 Det här är en rapport om personal som älskar och brinner för sitt jobb, djuren och samhällsuppdraget. Förutom lojalitet till både uppdraget och arbetsgivaren, samt rop på hjälp domineras den också av vittnesm
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Bryophytes constitute a diverse plant group with important roles in ecosystem functioning, in particular in arctic and subarctic environments. As they are physiologically strongly dependent on climatic conditions bryophytes could serve as indicators of ongoing climatic change. Their spores are generally dispersed by wind, and because of contrasting phenologies among species, the composition of the
LUCSUS Lund University Centre for Sustainability Studies ADAPTIVE CAPACITIES TO CLIMATE VARIABILITY AND CHANGE IN THE LAKE VICTORIA BASIN Uncertain futures SARA GABRIELSSON Lund Dissertation in Sustainability Science No. 3 LUCID Lund University Centre of Excellence for Integration of Social and Natural Dimensions of Sustainability ISBN 978-91-7473-310-5 LUCID Lund University Centre of Excellence f
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/uncertain-futures-phd-thesis-sara-gabrielsson.pdf - 2026-07-05
This essay investigates the impact of classroom gender composition on the mental health of adolescent students. Using data from the Health Behaviours of School-aged Children survey in the Czech Republic, we exploit idiosyncratic classroom variation in the gender composition within the same schools across different grades. We find that a higher proportion of female peers in the classroom has a detr
The Paris Agreement, adopted in 2015, paved the way for a new hybrid global climate governance architecture with both bottom-up and top-down elements. While governments can choose individual climate goals and actions, a global stocktake and a ratcheting-up mechanism have been put in place with the overall aim to ensure that collective efforts will prevent increasing adverse impacts of climate chan
We propose a consensus definition of "an exaggerated orthostatic pressor response" in subjects in whom systolic blood pressure increases ≥ 20 mmHg when going from supine to standing posture. This definition can be extended for seated to standing measurements. We reserve the term "orthostatic hypertension" for when this pressor response leads to an upright systolic blood pressure ≥ 140 mmHg. We bel
