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In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EP
Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare report
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used -1/4155,063 samples for independent replication. We identified 30 new bloo
Short videos featuring transnational marriage content involving African women and Chinese men (African-Chinese Interracial Family videos, hereafter ACIF) have gradually formed a stable content genre on Douyin in China. This generic stability is shaped by platform mechanisms, genre conventions, and accumulated audience expectations. Yet how this genre frames marital relationships and organizes race
The commercially important Atlantic bluefin tuna (Thunnus thynnus, ABFT) has recently returned to Nordic waters after being absent for half a century due to intense, unregulated overfishing and eventual stock collapse. The present study processed and explored big data obtained from Pop-off Satellite Archival Transmitters deployed on large (CFL 248 +/- 16 cm) ABFT (n =75) in the Skagerrak from 2017
Med anledning av kammarrättens dom i mål nr 4468-19 av den 20 novem-ber 2020 har tidpunkten för när en ansökan om upptagande till handel ska anses vara inlämnad på den reglerade marknaden Nasdaq Stockholm, och således när marknadsmissbruksförordnigen (”MAR”) blir tillämplig i en noteringsprocess, fastställts till tidpunkten för när Nasdaq Stockholms Admission Form B lämnas in. Detta innebär i prakAs a result of the Swedish Administrative Court of Appeal’s judgment in case no. 4468-19 of 20 November 2020, the time for when an application for admission to trading shall be considered to have been submitted to the regulated market Nasdaq Stockholm, and thus when the market abuse regu-lation (“MAR”) becomes applicable in a listing process, has been decided to the time of submission of Nasdaq St
OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort com
Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort Ashok Sharma1, Xiang Liu2, David Hadley3, William Hagopian4, Wei-Min Chen5, Suna Onengut-Gumuscu5, Carina Törn6, Andrea K. Steck7, B
Recent studies have shown that dissolved organic matter (DOM) decomposed by ectomycorrhizal (ECM) fungi increases adsorptive properties of organic matter towards soil mineral surfaces. Concomitantly, ECM fungi secrete secondary metabolites with iron reducing capacity that are thought to participate in non-enzymatic Fenton-based decomposition of DOM. The aim of this study was to investigate if the
What is the relationship between trust and the quality of political institutions in a society? According to an influential cultural perspective, social trust—the belief that most people can be trusted—is a value inculcated during individuals’ formative years, and remains fixed afterward. A second perspective holds that social trust reflects experiences throughout the life course, particularly inte
AIMS: Reduced lung function and adverse health outcomes are often observed. This study characterizes genetic susceptibility for reduced lung function and risk of developing a range of adverse health outcomes.METHODS: We studied 27,438 middle-aged adults from the Malmö Diet and Cancer study (MDCS), followed up to 28.8 years. Trait-specific Polygenic scores (PGS) for forced expiratory volume in 1 s
OBJECTIVES: The primary aim of this study was to describe the ultrasound features of various endometrial and other intracavitary pathologies in women without abnormal uterine bleeding (AUB) using the International Endometrial Tumor Analysis (IETA) terminology. The secondary aim was to compare our findings with published data on women with AUB. METHODS: This was a prospective observational study of
How people wake up and regain alertness in the hours after sleep is related to how they are sleeping, eating, and exercising. Here, in a prospective longitudinal study of 833 twins and genetically unrelated adults, we demonstrate that how effectively an individual awakens in the hours following sleep is not associated with their genetics, but instead, four independent factors: sleep quantity/quali
The Baltic Sea is one of the fastest-warming marginal seas globally, and its temperature rise has adversely affected its physical and biochemical characteristics. In this study, forty years (1982–2021) of sea surface temperature (SST) data from the advanced very high resolution radiometer (AVHRR) were used to investigate spatial and temporal SST variability of the Baltic Sea. To this end, annual
With the rising prevalence of both diabetes mellitus (DM) and peripheral arterial disease (PAD), the aim of this project was to examine the association between dietary intake and lifestyle on the risk of developing PAD among individuals with DM. The Malmö Diet and Cancer study was a prospective cohort study with baseline examinations carried out between 1991 and 1996 in Malmö, Sweden (n = 30,446).
Naturally occurring human genetic variants that are predicted to inactivate protein-coding genes provide an in vivo model of human gene inactivation that complements knockout studies in cells and model organisms. Here we report three key findings regarding the assessment of candidate drug targets using human loss-of-function variants. First, even essential genes, in which loss-of-function variants
The acceleration of DNA sequencing in samples from patients and population studies has resulted in extensive catalogues of human genetic variation, but the interpretation of rare genetic variants remains problematic. A notable example of this challenge is the existence of disruptive variants in dosage-sensitive disease genes, even in apparently healthy individuals. Here, by manual curation of puta
Structural variants (SVs) rearrange large segments of DNA1 and can have profound consequences in evolution and human disease2,3. As national biobanks, disease-association studies, and clinical genetic testing have grown increasingly reliant on genome sequencing, population references such as the Genome Aggregation Database (gnomAD)4 have become integral in the interpretation of single-nucleotide v
Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the function of an organism will be depleted of such variants in natural populations, whereas non-essential genes will tolerate their accumulation. However, predicted loss-of-function variants are enriched for annotation errors,
