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Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell carcinoma (SqCC) cases, and 27 355 controls, as well as multiple transcriptome and e
Previous reports have shown ambiguous findings regarding the possible associations between ischaemic stroke (IS) and single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) gene region. The SNP rs12188950 (or SNP45) has often been studied in this context. We performed a multi-centre study involving a large sample of 2599 IS patients and 2093 control subjects from the south and w
BACKGROUND AND PURPOSE: Extracellular adenosine triphosphate (ATP) regulates inflammatory cells by activation of the P2X(7) receptor. We hypothesized that polymorphisms in P2RX7 influence the risk of ischemic heart disease (IHD), ischemic stroke (IS) and cardiovascular risk factors and tested this hypothesis using genetic association studies. METHODS: Two loss-of-function SNPs in P2RX7 were genot
Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans.
SimSWE is a library of components for modeling and simulation of software engineering processes. It consists of a generic, implementation independent description of the components and a reference implementation using the MATLAB® / Simulink® environment. By providing ready-to-use building blocks for typical functionality, the library should facilitate and ease the use of simulation to analyze softw
Popular Abstract in Swedish Under de senaste åren har det svenska samhället förändrats när det gäller dess förhållande till religion och till Svenska kyrkan. Från att ha varit en statskyrka fram till år 2000 och därmed tidigare tillhört enhetskulturen och varit en majoritets kyrka, är Svenska kyrka idag en kyrka som är fri från staten och verkar i ett mångkulturellt samhälle där många olika kulturThe tradition for teenagers to participate in confirmation groups and be confirmed was formerly very strong in Sweden. Up to the 1970s, approximately 80-90 % of all young Swedes were confirmed. But in 2007, these courses were only attended by 37 %, according to the latest Church of Sweden statistics (Svenska kyrkan 2007a). The Aim of the thesis is: Using a Bildung perspective, the aim of the prese
The ATLAS Computing Model embraces the Grid paradigm and a high degree of decentralization and sharing of computing resources. The required level of computing resources means that off-site facilities will be vital to the operation of ATLAS in a way that was not the case for previous CERN-based experiments. The primary event processing occurs at CERN in a Tier-0 facility. The RAW data is archived
AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts dev
The paper examines the metaphysical ideas employed to embed Hellenistic astrology in an Indian religious and cultural context, relating them to questions of causality, determinism and moral freedom. These ideas are contrasted against the largely Thesophical adaptation of the same concepts, which in the 19th and 20th centuries formed the emerging modern astrology in Europe, and which led it to aban
Objective Intrauterine growth restriction (IUGR) is a recognized risk factor for neurological deficits later in life. Abnormal fetal blood flow in the presence of IUGR helps to distinguish fetuses with true growth impairment from those that are small but normally grown. This study aimed to evaluate the influence of IUGR with abnormal fetal blood flow on cognitive function and psychological develop
Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activi
A unified approach is presented for establishing exact integration of the constitutive equations in elastoplasticity, assuming the total strain-rate direction to be constant. This unified approach includes all previous exact integration procedures as special cases and, in addition, some new closed-form solutions are derived for combined kinematic and isotropic hardening. Special emphasis is laid o
BACKGROUND: Cerebral endothelial dysfunction occurs in a spectrum of neurodegenerative diseases. Whether biomarkers of microvascular endothelial dysfunction can predict dementia is largely unknown. We explored the longitudinal association of midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal endothelin-1 (CT-proET-1) and midregional proadrenomedullin (MR-proADM) with dementia and s
The Amazon basin is characterized by a strong interplay between the atmosphere and vegetation. Anthropogenic land use and land cover change (LULCC) affects vegetation and the exchange of energy and water with the atmosphere. Here we have assessed potential LULCC impacts on climate and natural vegetation dynamics over South America with a regional Earth system model that also accounts for vegetatio
BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen
Popular Abstract in Swedish Det övergripande området för min studie är lärararbetet. Initialt riktar jag blickarna mot lärare som verkar i den svenska grundskolan. Den övergripande forskningsfrågan lyder: Hur är lärararbetet? Även om det i grundad teori framstår som önskvärt att forskaren ska ge sig ut på fältet utan förutfattade idéer och perspektiv som tvingar data in i förutbestämda analyser, gThe aim of this study is to generate a grounded theory about the work done by teachers. The initial area of data collection was the work done by teachers in their non-regulated hours, in which the teachers are expected to carry out professional activities like planning, preparation, correcting and spontaneous contacts with students, parents and colleagues. Data was collected and analysed according
The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) c
