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BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.METHODS
Hormone secretion from pancreatic islets is essential for glucose homeostasis and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are critical for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also Neurog3+ endocrine progenitor
AIMS: Carbohydrate antigen 125 (CA125), a mucin produced by serosal cells in response to mechanical and inflammatory stimuli, has emerged as an important biomarker to guide risk stratification in heart failure (HF). The prognostic value of CA125 in acute coronary syndrome (ACS) patients is less explored.METHODS: In a cohort of 524 ACS patients (73% males, mean age 67 ± 12 years), we assessed the a
Background: Healthcare workers in obstetric clinics may be exposed to airborne SARS-CoV-2 when treating patients with COVID-19.Method: In this study, performed during the midst of the pandemic, air samples werecollected in delivery rooms during childbirth and analysed for SARS-CoV-2 RNA content.Result: Six of 28 samples collected inside delivery rooms were positive for SARS-CoV-2, but none in ante
This thesis examines the relationship between international law protecting refugees and national legislation in Sweden and in the UK. International protection is afforded by the 1951 Geneva Convention Relating to the Status of Refugees. But also general international human rights instruments are relevant. These include the Universal Declaration of Human Rights, the International Covenant on Civil
BACKGROUND: Type 2 diabetes (T2D) patients are at a greater risk of cardiovascular events due to aggravated atherosclerosis. Oxidized LDL (oxLDL) has been shown to be increased in T2D plaques and suggested to contribute to plaque ruptures. Despite intensified statin treatment during the last decade the higher risk for events remains. Here, we explored if intensified statin treatment was associated
Alzheimer's disease is a neurodegenerative condition which involves heavy neuronal cell death linked to oligomers formed during the aggregation process of the amyloid β peptide 42 (Aβ42). The aggregation of Aβ42 involves both primary and secondary nucleation. Secondary nucleation dominates the generation of oligomers and involves the formation of new aggregates from monomers on catalytic fibril su
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the unc
Aims/hypothesis: Roux-en-Y gastric bypass surgery (RYGB) frequently results in remission of type 2 diabetes as well as exaggerated secretion of glucagon-like peptide-1 (GLP-1). Here, we assessed RYGB-induced transcriptomic alterations in the small intestine and investigated how they were related to the regulation of GLP-1 production and secretion in vitro and in vivo. Methods: Human jejunal sample
Objectives: To examine the relationship between the English index of multiple deprivation (IMD) and the incidence of stillbirth and assess whether IMD contributes to the prediction of stillbirth provided by the combination of maternal demographic characteristics and elements of medical history. Methods: This was a prospective, observational study of 159 125 women with a singleton pregnancy who att
This study makes a numeric and visual comparison of two different multibeam echo sounding (MBES) surveys performed at the exact same location, in an effort to establish how reliable and comparable the vertical depth measurements are. The horizontal position uncertainty is not issued in this study. The analysis was performed on data delivered by two survey contractors, The Norwegian Coastal Admini
En fusion innebär att två eller flera bolag slås samman genom att samtliga tillgångar och skulder hos det överlåtande bolaget tas över av det övertagande bolaget och det överlåtande bolaget upplöses utan likvidation. Det finns två olika grundvarianter av fusioner, absorption och kombination. Absorption innebär att ett eller flera bolag fusioneras in i ett existerande övertagande bolag. KombinationA merger is a transaction in which at least two companies are merged by all the assets and liabilities of the transferring company being taken over by the acquiring company and the transferring company being dissolved without liquidation. There are two different versions of mergers, “absorption” and “combination”. Absorption means that at least one company is merged into an existing acquiring comp
Den internationella organisationen OECD har tagit fram en omfattande åtgärdsplan, BEPS-projektet, som har till syfte att förhindra att nationella skattebaser eroderas på grund av att internationellt verksamma bolag allokerar beskattningsbara vinster till länder med låga skattesatser. Gränsöverskridande koncerninterna transaktioner är en dominerande metod för att åstadkomma önskad vinstallokering. The international organization OECD has developed a comprehensive action plan, the BEPS project, which aims to prevent national tax bases to erode due to that multinational companies allocate taxable profits in countries with low tax rates. Cross-border intra-group transactions is a predominant method to achieve the desired profit allocation. Transfer pricing rules are therefore a central part of
The commercially important Atlantic bluefin tuna (Thunnus thynnus, ABFT) has recently returned to Nordic waters after being absent for half a century due to intense, unregulated overfishing and eventual stock collapse. The present study processed and explored big data obtained from Pop-off Satellite Archival Transmitters deployed on large (CFL 248 +/- 16 cm) ABFT (n =75) in the Skagerrak from 2017
Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early
High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale
Aims Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyocyte passive stiffness and diastolic function, is not well understood. Non-coding RNA transcripts from the antisense strand of protein-coding genes have been shown to regulate alternative
