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Aims: Hypertension is the leading cause for the development of heart failure (HF). Here, we aimed to identify cardiomyocyte stretch-induced circulating biomarkers for predicting hypertension-associated HF. Methods and results: Circulating levels of 149 proteins were measured by proximity extension assay at baseline examination in 4742 individuals from the Malmö Diet and Cancer study. Protein level
Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better
AIMS: We aimed to search for associations between cognitive test results with mortality and rehospitalization in a Swedish prospective heart failure (HF) patient cohort.METHODS AND RESULTS: Two hundred and eighty-one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making T
Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell carcinoma (SqCC) cases, and 27 355 controls, as well as multiple transcriptome and e
Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans.
The Swedish debate both on the role of literature and on the social position of women underwent rapid change during the thirty years from 1960 to 1990. In Bringing the Personal to Market: Narrative, Subject-Matter and Contemporary History in the First Novels of Kerstin Strandberg, Enel Melberg and Eva Adolfsson, the debut novels of three female authors’ are close-read from a thematic and narratolo
Aggressiv skatteplanering har i takt med den digitala ekonomin blivit alltmer vanligt. På grund av multinationella företags globala natur har dessa en fördel i skattehänseenden genom att de kan flytta vinster mellan länder i syfte att betala mindre skatt. Både inom OECD och EU pågår ett ständigt arbete med att minska den aggressiva skatteplaneringen globalt. Genom BEPS-projektet har ett par verktyIn the more digital economy aggressive tax planning has become increasingly common. Due to their global nature, multinational corporations can move profits between countries in order to reduce their taxes. Both the OECD and the EU are continuously working to reduce the aggressive tax planning globally. Through the BEPS project several tools have been developed. One of these is country-by-country-r
Denna uppsats handlar om en princip som vuxit fram inom folkrätten de senaste decennierna, kallad Responsibility to protect (R2P). Den är en undantagsregel till suveränitetsprincipen och innebär i korthet att om en stat inte kan eller vill skydda sin befolkning från vissa specifikt stadgade brott, har den internationella gemenskapen en möjlighet att intervenera i ett land, utan landets tillstånd. This essay is about a principle in international law that has emerged in the last decades, called Responsibility to protect (R2P). It constitutes an exception to state sovereignty. In short, if a state is unable or unwilling to protect its citizens from some specific crimes, the international community is given an opportunity to intervene in that state without the state’s consent. The Chinese gov
BACKGROUND: It remains unclear why cool temperatures cause more persistent adverse health effects compared to hot weather. Fluid homeostasis may constitute a causal link between past temperatures and adverse health effects. In this study we investigated the association between past outdoor temperatures and current fluid homeostasis.METHODS: We studied participants from five cohorts during three de
Detta examensarbete avser att utreda vad det finns för möjligheter till stöd och skydd för flickor som utsätts för hedersrelaterat våld och förtryck. Hedersrelaterat våld och förtryck har sin grund i en patriarkal maktordning. Kön, makt, sexualitet och dess kulturella föreställningar är, grunden i hedersrelaterat våld och förtryck. Varje år utsätts flickor och unga kvinnor i Sverige för hedersrelaThis thesis will investigate what happens to girls who are victims of honour- related violence committed by their families to protect the family’s honour. The intention of this thesis is to clarify what help is available to these girls. Honour- related crime was first discussed in Swedish society at the beginning of the 1990’s. Honour- related violence has its roots in a patriarchal power structur
Climate change may affect the yield of mass-flowering crops by altering the interplay between pest pressure and service delivery by pollinators, but realistic predictions need to account for the frequent use of insecticides in conventional farming. We tested the interactive effects of insecticide use and warmer winter conditions on oilseed rape (Brassica napus) production, pest pressure, and the a
Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), force
Temperature is a key constraint on ecosystem respiration but is typically measured at only one or a few points across a study site. Given the exponential relationship between temperature and respiration, small differences in temperature across a heterogeneous ecosystem may result in large differences in respiration fluxes. These differences are not captured in current respiration models which use
The boreal biome exchanges large amounts of carbon (C) and greenhouse gases (GHGs) with the atmosphere and thus significantly affects the global climate. A managed boreal landscape consists of various sinks and sources of carbon dioxide (CO2), methane (CH4), and dissolved organic and inorganic carbon (DOC and DIC) across forests, mires, lakes, and streams. Due to the spatial heterogeneity, large u
The global temperature rise is proportional to the cumulative amount of CO2 emissions to the atmosphere. This observation is consistent between climate models and historical observations. It has also given rise to the concept of a carbon budget, which sets a threshold for the amount of CO2 that can be emitted into the atmosphere while still fulfilling political goals such as the Paris Agreement.Te
Introduction: Alpha-1-antitrypsin (AAT) has been shown to inhibit SARS-CoV-2 cell entry and suggested as a therapeutic agent for COVID-19. Furthermore, epidemiological association of high prevalence of Alpha-1-antitrypsin deficiency (AATD) and regional severity of COVID-19-impact has been hypothesized. In our study setting, the estimated prevalence rates of mild (PI*MZ, PI*SS or PI*MS) and moderat
Exocytosis in excitable cells is essential for their physiological functions. Although the exocytotic machinery controlling cellular secretion has been well investigated, the function of the vesicular cargo, i.e. secretory granular content remains obscure. Here we combine dSTORM imaging and single-domain insulin antibody, to dissect the in situ structure of insulin granule cores (IGCs) at nano lev
This study investigates possible structural changes of an intrinsically disordered protein (IDP) when it adsorbs to a solid surface. Experiments on IDPs primarily result in ensemble averages due to their high dynamics. Therefore, molecular dynamics (MD) simulations are crucial for obtaining more detailed information on the atomistic and molecular levels. An evaluation of seven different force
