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The cone snail is the only invertebrate system in which the vitamin K-dependent carboxylase (or gamma-carboxylase) and its product gamma-carboxyglutamic acid (Gla) have been identified. It remains the sole source of structural information of invertebrate gamma-carboxylase substrates. Four novel Gla-containing peptides were purified from the venom of Conus textile and characterized using biochemica
Silver birch and common oak are known to be sensitive to standard practices in nurseries and they often show poor establishment when transplanted in urban areas. Lifting date and time in cold storage have a strong influence on stress tolerance and plant vitality. This study was carried out to assess the effect of lifting date and storage time on partial photosynthesis measured by chlorophyll fluor
Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined this relationship in European cohorts comprising altogether almost 22,000 subjects, in the framework of a European collaborative project (CancerRiskBiomarkers). The present paper gives an overview of some of the results of
The aim of the present study was to analyse quantitatively, on a cat gastrocnemius preparation in vivo, the effects of i.a. or i.v. administered glyceryl trinitrate (GTN), sodium nitroprusside (SNP) or nitric oxide (NO dissolved in saline) on vascular resistance (tone) in the following consecutive vascular sections: Large-bore arterial resistance vessels (> 25 microns), small arterioles (< 25 micr
Popular Abstract in Swedish Protein kinas C (PKC) är en familj serin/treonin kinaser som har en viktig roll i regleringen av olika funktioner i cellen. PKC kan delas in i klassiska (alpha, betaI, betaII and gamma), nya (delta, epsilon, eta and theta) och atypiska (zeta and iota/lambda) isoformer beroende på skillnader i hur de regleras. När PKCalpha är inaktivt bidrar intramolekylära bindningar tiMembers of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in cellular regulation. Depending on differences in regulation, PKCs can be divided into classical (alpha, betaI, betaII and gamma), novel (delta, epsilon, eta and theta) and atypical (zeta and iota/lambda) isoforms. When PKCalpha is inactive it is maintained in a closed conformation by intramolecular inte
Popular Abstract in Swedish Våtmarker är en naturtyp som man finner i övergångszoner mellan land och vatten. Idag talas det mycket om våtmarkers positiva natur- och miljövärden i avrinningsområden i det moderna jordbrukslandskapet. Våtmarker ger omväxling i landskapet och är viktiga biotoper för växter och djur. I våtmarker ansamlas mycket dött växtmaterial och tillsammans med en god tillgång på vIn this thesis, I have studied nitrogen turnover processes in watermeadows. A watermeadow is a wetland where water infiltrates through the soil of a grassland field. It is hypothesized that infiltration of water through the soil matrix promotes nutrient transformations compared to surface flow of water, by increasing the contact between water, nutrients, soil organic matter and bacteria. I have st
We have previously identified C1 domain-containing phosphatase and TENsin homologue (C1-TEN) as being an intracellular binding partner for Axl receptor tyrosine kinase (RTK). C1-TEN is a tensin-related protein that houses an N-terminal region with predicted structural similarity to PTEN. Here, we report our observations on the effects of ectopic expression of C1-TEN in HEK293 cells, which resulted
Popular Abstract in Swedish Missbrukande kvinnor och mammor har ofta fördömts av samhället och av människor i sin omgivning. De har setts som ansvarslösa kvinnor och olämpliga mammor utifrån en samhällssyn, att barn och missbruk inte går ihop. De livshistoriska intervjuerna med missbrukande kvinnor och mammor, som avhandlingen bygger på visar, att kvinnorna både vill vara respektabla och ta väl haThe aim of the dissertation is to describe the conditions under which substance abusing women live with regard to their families, the substance abuse and treatment. The interaction between the substance abusing women and the institutional expectations is analysed from gender and class perspective. The dissertation is based on interviews with two groups of substance abusing women: 12 mothers, livin
To investigate why human immunodeficiency virus type 2 (HIV-2) is less virulent than HIV-1, the evolution of coreceptor usage, autologous neutralization, envelope sequence and glycosylation was studied in sequentially obtained virus isolates and sera from four HIV-2-infected individuals. Neutralization of primary HIV-2 isolates was tested by a cell line-based assay and IgG purified from patients'
The research objective for this thesis are two problematic yet interweaving occurrences observed in earlier research on the Abu Ghraib scandal (2004) and its image material. Firstly in terms of methodology, a restricted amount of images in which three single images, “Hooded Man”, “Man on Leash” and “Piled Bodies” are overrepresented and frequently regarded as descriptive for the scandal as such. S
I denna text presenteras en kvalitativ intervjustudie baserad på utsagor från tio informanter med utgångspunkt i hur kriminella nätverk har förändrats. Forskning har visat att Sverige är unikt vad gäller ökningen av skjutvapenvåld. Den grupp som står för majoriteten av våldet är unga män. Den organiserade brottsligheten har genomgått en förändring från MC-gängens tydliga organisationsstruktur och
Hazardous substances i.e., substances of concern pose a risk to both human health and the environment. Stricter regulations and increased focus on circular economy are pushing organisations to substitute hazardous chemicals to safer alternatives. Substitution can lead to a number of benefits, for example cost reductions and competitive advantages. There has been a growing focus on substitution sin
Large and old trees provide important habitat structures and support a high diversity of species. Habitat continuity and landscape connectivity is crucial for species associated with oaks. Fragmentation, agriculture intensification and changed forest management has caused a reduction of old and large oaks, which threatens the long-term persistence of oak associated species by reducing habitat cont
Sverige är känt som ett av världens mest jämställda länder och andelen kvinnor på arbetsmarknaden är bland de högsta i världen. Trots detta finns det fortfarande stora orättvisor när det gäller fördelningen bland maktpositioner på arbetsmarknaden. Män besitter fler och mer inflytelserika chefspositioner än vad kvinnor gör. Både EU och Sverige har länge arbetat för att jämna ut könsfördelningen på
Bygg- och fastighetssektorn står för stora utsläpp av växthusgaser från byggnadsmaterial- och energianvändning. Byggbranschen står idag för ca en femtedel av Sveriges totala koldioxidutsläpp. Ett område med stor potential är byggnadsmaterial där IsoTimber är ett av företagen som driver utvecklingen framåt. IsoTimber är en relativt ny aktör inom byggsektorn som tillverkar prefabricerade väggar i trThe construction and real estate sector accounts for a large part of the emission of greenhouse gases from the usage of building material and energy. The construction industry today accounts for about one-fifth of Sweden’s total carbon dioxide emissions. One area with great potential is building materials where IsoTimber is one of the companies that drive the development forward. IsoTimber is a re
All around the world is the form of the built environment playing a significant role in either enabling or inhibiting outdoor activities. When it comes to winter and Winter cities, it is a challenge how to enable and encourage outdoor activities and soft mobility as the harsh conditions often make it uncomfortable to spend longer periods of time outdoors. A major urban design challenge in Winter
