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Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide level. Our aim is to enhance understanding of familial risks in childhood nervous system cancers. Methods: We used the Swedish population and cancer data from years 1958–2021 to a
Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by
Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In the current work, we aimed to assess the potential of the combination of MSCs with a proangiogenic elastin-like recombinamer (ELR)-based hydrogel in
Organic pollutants in aquatic environments pose a threat to ecosystems and human health, a challenge that requires urgent resolution. This urgent threat highlights the need for the development of efficient technologies for pollutant detection and degradation in environmental protection. This study presents the successful fabrication of a composite nanomaterial consisting of Ag nanoparticle-decorat
Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st
BACKGROUND: Postmortem MRI has opened-up avenues to study brain structure at ultra high-resolution revealing details not possible to observe with in vivo MRI. Here, we present a novel package (purple-mri) which performs tissue segmentation, anatomical parcellation and spatial normalization of postmortem MRI. Additionally, we provide a framework to perform point-wise surface-based group-level studi
Objective To investigate the relationship between active commuting and atherosclerosis in middle age using state-of-the-art coronary CT angiography (CCTA). Methods This cross-sectional study used data from the Swedish CArdioPulmonary bioImage Study (SCAPIS) and included 23 722 randomly recruited individuals aged 50–64 years from six different regions in Sweden. The exposure was commuting mode, ass
Questions: Earth observation is an important tool in biological monitoring. Previous studies have shown that variation in grassland canopy reflectance can explain gradients in plant community composition. However, there is a need for methods that allow the interpretation of the overall spectral signal of complex grassland vegetation in terms of existing knowledge about individual species' habitat
Neophobia, or aversion to novelty, is important for adaptability and survival as it influences the ways in which animals navigate risk and interact with their environments. Across individuals, species and other taxonomic levels, neophobia is known to vary considerably, but our understanding of the wider ecological drivers of neophobia is hampered by a lack of comparative multispecies studies using
This doctoral thesis investigates mediaeval earthenware production, distribution and consumption based on material from Lund, Sweden, moving beyond simple technological shifts to explore the interplay of material factors, social practices, and economic influences. It presents a typology of hard greyware, redware and glazed redware, as well as the chemical analysis of circa 400 samples. The study a
Amelogenin self-assembly is a critical step in enamel matrix organization, supporting the spatial confinement of transient ACP and orchestrating hydroxyapatite nucleation and ordered growth. Studies have demonstrated that amelogenin self-assembles into nanoribbons by forming an amyloid-like structure that matches the cross-β pattern observed in the developing enamel matrix. However, molecular dete
Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based
Pathogenic bacterial infections lead to bacterial resistance and biofilm formation, causing significant suffering and presenting an urgent issue to be addressed. Polymer materials have garnered considerable attention in the antibacterial field due to their functional moldability and molecular structure designability. These materials can achieve various antibacterial functions by regulating their m
Combined quantum mechanics and molecular mechanics (QM/MM) calculations are a popular approach to study reaction mechanisms of enzymes. However, recently, the reproducibility of such calculations has been questioned, comparing the results of two software: NWChem and Q-Chem. Here, we continue and extend this study by including three additional software─ComQum, ORCA, and AMBER─using the same test ca
Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an
Over the past decade, organic–inorganic hybrid perovskites have revolutionized next-generation semiconductors, driving unprecedented advancements in cost-effective optoelectronics. While lead-based perovskite semiconductors exhibit exceptional optoelectronic properties, their inherent toxicity and vulnerability to environmental degradation remain significant barriers to widespread commerciali
Ung och skuldtyngd ger en djupgående inblick i upplevelsen av att som ung vuxen leva med skuldsättningsproblem - överskuldsättning - i dagens moderna konsumtions- och kreditsamhälle. Under två års tid har forskarna genom upprepade etnografiska intervjuer följt 18 personer mellan 18 och 25 år som är överskuldsatta. Resultaten besvarar frågor som: Hur kommer det sig att unga personer får problem med
The radioactive noble gas radon (222Rn) is a suitable tracer for atmospheric transport and mixing processes that can be used to evaluate and calibrate atmospheric transport models or to estimate greenhouse gas (GHG) emissions using the so-called radon tracer method (RTM). However, these applications require reliable estimates of the 222Rn fluxes from the soil. This study evaluates two process-base
