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ABSTRACT: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there are limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. In a prospective observational study, CSF inflammatory mediators were compared between patients with osteoarthritis (OA) who were undergoing total hip arthroplast

Komplexa tal kom till som ett verktyg för att lösa andra- och tredjegradsekvationer. Till en början sågs de som värdelösa utanför det specifika användningsområdet, men har sedan dess visat sig vara mycket användbara inom flera matematiska fält och även utanför matematiken. Ett sådant exempel är kvantmekanik inom fysiken. Den gren av matematiken som tagit de komplexa talen från ekvationslösning tiThis thesis discusses an extension of the classical maximum modulus principle to unbounded domains, called the Phragmén-Lindelöf principle. The principle is illustrated in strips, half planes and sectors, as well as through the related Hadamard theorems. The thesis is concluded by proving applications of the Phragmén-Lindelöf principle within Fourier analysis and operator theory. The applications

BACKGROUND: The risk of infection-related death is high in patients undergoing dialysis. This study aimed to identify the modifiable risk factors for PD-related infections in patients undergoing peritoneal dialysis.METHODS: This was a population-based retrospective cohort study conducted in Skåne, South Sweden, which included all patients receiving peritoneal dialysis (PD) between 2011 and 2020. T

Background: Diversion—patients who sell or share their medication—is a hotly debated but rela-tively unresearched phenomenon. We have investigated the prevalence of self-reported diversion ofmethadone and buprenorphine at OST programs in Sweden. We have also examined if demographic,treatment, and social factors can be associated with an increased risk of diversion. Methods: Structured interviews w

Understanding the drivers of diversity and change in regional Neolithization trajectories has emerged as a major theme in World Prehistory with new insights appearing in many parts of the globe. In Northeast Asia, research on Neolithic transition over the past two decades has focused primarily on millet and rice domestication and their role in the rise of farming, social complexity, and early Chin

Sex-based differences in immune responses are a well-established phenomenon, with males generally displaying stronger innate immunity and females exhibiting enhanced adaptive responses. The androgen receptor (AR) is the main effector of androgen-induced changes in the body through genomic transcription and has been implicated as one of the origins of sex-based differences in immunity. This thesis

Syfte & mål: Syftet med detta examensarbete är att få en bättre förståelse för adaptiv återanvändning av kulturhistoriska byggnader och återbruk av byggmaterial inom byggbranschen, samt hur några vanliga utmaningar kopplat till detta kan hanteras. Målet med examensarbetet är att genom en fallstudie av Gjuteriet undersöka hur adaptiv återanvändning av kulturhistoriska byggnader och återbruk a

Ung och skuldtyngd ger en djupgående inblick i upplevelsen av att som ung vuxen leva med skuldsättningsproblem - överskuldsättning - i dagens moderna konsumtions- och kreditsamhälle. Under två års tid har forskarna genom upprepade etnografiska intervjuer följt 18 personer mellan 18 och 25 år som är överskuldsatta. Resultaten besvarar frågor som: Hur kommer det sig att unga personer får problem med

Adolescent girls are particularly susceptible to iron deficiency due to increased iron requirements during the pubertal growth spurt, combined with iron loss following menarche. This study aimed to investigate the prevalence of heavy menstrual bleeding in an adolescent population using the SAMANTA questionnaire and to explore its relationship with dietary habits and iron deficiency. This cross-sec

Den här uppsatsen fokuserar på folksånger från Epirus som handlar om xenitia. Ordet xenitia innebär exil eller migration till en främmande plats och det främmandeskap som upplevs på den nya platsen. Epirus är en geografisk region i västra Grekland och anses vara födelseplatsen för folksången. Epirus var förslavad under det osmanska riket i över fyrahundra år och invånarna i regionen tvingades ofta

Studien syftade till att undersöka hur frikända personers medvetenhet förstås i domstolens motivering till att medvetenhetskravet inte är uppfyllt, hur dessa aspekter förhåller sig till psykologisk förståelse av förändrade medvetandetillstånd samt jämföra hur informationen som ligger till grund för rättsliga motiveringar förhåller sig till den rättspsykiatriska bedömningen. Studiens genomfördes i The aim of the study was to investigate how Swedish courts perceive the consciousness of acquitted individuals whose grounds for acquittal were lack of consciousness, and how such perceptions relate to psychological understandings of altered states of consciousness. Another aim was to explore how the information that forms the basis for the courts' reasoning corresponds with the content of the

Conventional wastewater treatment plants are designed for treating manmade wastewater (e.g., from households and industries) and to protect the environment (e.g., receiving water bodies) and humans from adverse effects.The objective of this work was to investigate the feasibility of treating municipal wastewater without a biological treatment step by applying different separation processes, such a

Objectives Increased cancer risks have been reported among workers in the rubber manufacturing industry employed before the 1960s, but it is unclear for workers hired subsequently. The present study focused on cancer incidence among rubber workers first employed after 1975 in Sweden and the UK. Methods Two cohorts of rubber workers employed for at least 1 year were analysed. Standardised incidence

Background The activity of the human enzyme thiopurine methyltransferase (TPMT) varies greatly between individuals because of genetic polymorphism. TPMT is involved in the detoxification and activation of thiopurines such as 6-mercaptopurine, 6-thioguanine, and azathioprine. These drugs are used in the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. A total of 29 sequence

Ex vivo gene transfer to the CNS has so far been hampered by instability of transgene expression. To avoid the phenomenon of transgene down-regulation, we have employed strong, constitutive promoters and compared this expression system with the inducible Tet expression system incorporated in a single plasmid vector or in lentiviral vectors. Plasmid-based transgene expression directed by the consti

Background: Free and total human kallikrein 2 (hK2) might improve the discrimination between prostate cancer and benign prostatic hyperplasia. Concentrations of hK2 are 100-fold lower than concentrations of prostate-specific antigen (PSA); therefore, an hK2 assay must have a low detection limit and good specificity. Methods: PSA- and hK2-specific monoclonal antibodies were used in solid-phase, two

Background: Total hip joint replacement (THR) is a high volume, effective intervention for hip osteoarthritis (OA). However, indications and determinants of outcome remain unclear. The 'EUROHIP consortium' has undertaken a cohort study to investigate these questions. This paper describes the variations in disease severity in this cohort and the relationships between clinical and radiographic sever

The palynofloral changes around the Cretaceous-Paleogene (K-Pg) mass extinction event reveal the fine details of vegetation response to a global environmental crisis-in this case an asteroid impact in Mexico 65.5 million years ago. Due to the extinction of several plant taxa at the K-Pg boundary, palynostratigraphy is a prime tool for localizing the Cretaceous-Paleogene boundary in non-marine succ

Background: The Btk (Bruton's tyrosine kinase) gene has been shown to be mutated in the human immunodeficiency disease, XLA (X-linked agammaglobulinemia). Btk is a member of the Tec family of cytosolic protein tyrosine kinases with distinct functional domains PH, TH, SH3, SH2, and kinase. Mutations have been observed in each of the Btk subdomains in XLA. We have analyzed the Btk gene in six XLA pa