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Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

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Abstract in French:Cet article contribue à la recherche sur la géopolitique urbaine par une théorisation « extrospective » du pouvoir local sur la scène internationale – c’est-à-dire une orientation du développement socio-économique qui encourage tant la concurrence que la coopération entre les entités métropolitaines au-delà des frontières de l’État-nation. Empiriquement, l’article se concentre sThis article contributes to research on urban geopolitics through an extrospective theorization of local territorial influence on the international stage. Empirically, the article focuses on a comparative study of extrospective development initiatives from Malaga (Spain) and Mazara del Vallo (Sicily) that have recently emerged in response to the effects of the Great Recession. We examine the symbo

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Popular Abstract in Swedish Extern fixation är en metod för skelettfixation där perkutana pinnar och/eller vajrar fästes i skelettet och fixeras i en yttre metallram. Extern fixation används alltmer vid frakturläkning och förlängning/korrektion av deformiteter. En extern fixation ger stabilitet åt frakturer och osteotomier och möjlighet till gradvis förlängning/korrektion av deformiteter. Belastni

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Blood transfusions were dangerous and prohibited, until medicine developed modern techniques in the middle of the last century. Multi-trauma patients often present hard-to-identify multifactorial coagulopathies which should be recognized and treated before a transfusion is envisaged.

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The aim of this article is to show that at the end of the 13th century there’s a change of approach to the sophistical syllogism, going from a definition based on its formal features to a definition based on its pragmatic features. The first position is put forward by Simon of Faversham, during the 1280s, probably during his stay in Paris. The second position is put forward by Radulphus Brito, the

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Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+protects against inactivation and modification, in agreement with the study onE. colidUTPase (Vertessyet al.(1994)Biochim. Biophys. Acta1205, 146-150). Amino acid analyses of nitrated dUTPases