Filtyp
The aim of this essay is to make clear, whether or not, textile research is visualised in a wider archaeological discussion today. The aim is then to discuss what the archaeological and textile technological research situation in Scandinavia looks like today, and how that relate to what has happened in these two research fields during the years. This essay also has a purpose to find out if there i
Despite the increasing level and number of techniques deployed to generate more robust, better-producing microbial cell factories for production of chemicals, the number of products that reach commercial feasibility is still very low. Many hurdles come along the way as it has been observed that strains designed in the laboratory do not perform as expected in industrial-scale bioreactors. For insta
Introduction: Glioblastoma is the most aggressive form of primary brain tumor in adults. Current treatment including chemotherapy poses a limitation due to consequences of systemic toxicity. Further studies for alternative, multimodal treatments are necessary. Antisecretory factor is an endogenous protein. Studies have shown that it has anti-inflammatory and immune modulatory effects in experiment
Cities have a crucial importance from the sustainability point of view. More than 50% of the global population lives in cities, therefore urban dwellers’ environmental knowledge can be of critical importance. Many argue that an important part of environmental knowledge is acquired outside of a formal school setting, therefore in this thesis I explore learning processes connected to community garde
Problematiken kring räntesnurror uppmärksammades första gången på 1990-talet i det så kallade Mobil-Oilfallet. Vid denna tid var begreppet räntesnurror ännu inte myntat och Skatteverket hade inte insett att skatteplaneringsförfarandet kunde komma att årligen undandra staten flera miljarder kronor i skattepengar. Problemet låg i den obegränsade ränteavdragsrätten i 16 kap. 1 § IL som gjorde att konThe problem of interest turbines (Swedish: räntesnurror) was first recognized in the 1990s in the so-called Mobile Oil case. At this time, the concept of interest turbines was not yet coined and the Swedish Tax Authority had not realized that this kind of tax planning procedure could cost the state several billion crowns in tax money. The problem consisted in the unlimited interest deduction in ch
Human beings in modern society spend more than 90% of their time indoors to live, work, and socialize. To improve health, quality of life and task performance, integrative lighting is designed to give the right light at the right time at the eye to stimulate circadian entrainment. Current designs for integrative lighting consider rooms as black boxes, overlooking the contribution of daylight to th
Research in cancer is an ongoing project which not only includes finding more efficient treatment therapies, but also achieving a greater knowledge of how proteins of interest are targeted by inhibitors. Furthermore, research in this field can give us greater knowledge about the development of cancer cells if they are modified. One enzymatic protein family, the PARPs, has been widely studied for d
Popular Abstract in Swedish Byggandet av en järnvägstunnel genom Hallandsås har kommit att innebära ingrepp i och förändring av den traditionella landskapsbilden. Storskaliga och industriellt betonade infrastrukturprojekt är därför, ur lokalsamhällets perspektiv, inte bara en fråga om eventuella nya arbetstillfällen, modernisering och utveckling. Baksidan kan vara att hembygdens specifika och omis
Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (T) bound to thrombomodulin (TM), a membrane receptor present on the surface of endothelial cells. The understanding of this complex biological system is in part limited due to the lack of integration of experimental and structural data. In the work presented here, we analyze the PC-T-TM pathway in t
Background: CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1) variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the pathogenicity of R5 strains are poorly understood. To better understand envelope glycoprotein (Env) determinants contributing to pathogenicity of R5 viruses, we characterized 37 full-length R5 Envs from cross
Like many other lakes, Lake Ringsjön in Sweden has a long history of eutrophication problems. Eutrophication of lakes is mainly due to surplus of phosphorus. Most phosphorus reaches Lake Ringsjön from adjacent watercourses. In order to initiate action plans to reduce phosphorus concentrations in the lake, it is of great importance to know which watercourses have high phosphorus concentrations. Pho
It is important to obtain accurate three dimensional structures of molecules and proteins to understand and predict their function and behaviour. X-ray crystallography is the major technique to determine three dimensional structures of proteins. Although there have been major improvements on the experimental side in determining crystallographic data, only small progress has been made on the comput
Pain is a significant health concern for children living with cerebral palsy (CP). There are no population-level or large-scale multi-national datasets using common measures characterizing pain experience and interference (ie, pain burden) and management practices for children with CP. The aim of the CPPain survey is to generate a comprehensive understanding of pain burden and current management o
Urbanization is a major contributor to biodiversity declines. However, studies assessing effects of urban landscapes per se (i.e., disentangled from focal habitat effects) on biodiversity across spatial scales are lacking. Understanding such scale-dependent effects is fundamental to preserve habitats along an urbanization gradient in a way that maximizes overall biodiversity. We investigated the i
Background: The mismatch between the limited availability versus the high demand of participants who are in the pre-dementia phase of Alzheimer’s disease (AD) is a bottleneck for clinical studies in AD. Nevertheless, potential enrollment barriers in the pre-dementia population are relatively under-reported. In a large European longitudinal biomarker study (the AMYPAD-PNHS), we investigated main en
Background: Chronic breathlessness adversely impacts people with chronic obstructive pulmonary disease and their caregivers (family and friends), who may, in turn, experience significant burden due to their caregiving role. Sustained-release morphine may reduce chronic breathlessness in some patients, which may have an impact on caregivers’ perceived burden. Aim: To explore the impact on caregiver
Sedimentary molybdenum (Mo) and uranium (U) enrichments are widely used to reconstruct changes in bottom water oxygen conditions in aquatic environments. Until now, most studies using Mo and U have focused on restricted suboxic-euxinic basins and continental margin oxygen minimum zones (OMZs), leaving mildly reducing and oxic (but eutrophic) coastal depositional environments vastly understudied. C
Summary: In this prospective study in Swedish elderly men, PAD based on an ABI < 0.9 was associated with an increased risk of hip fracture, independent of age and hip BMD. However, after further adjustments for comorbidity, medications, physical function, and socioeconomic factors, the association diminished and was no longer statistically significant. Introduction: To examine if peripheral arteri
