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Pentaklorfenol (PCP) är en klorerad aromatisk förening som användes flitigt för att behandla trä mot mikrobiell nedbrytning innan den blev förbjuden på 70-talet. På grund av dess höga löslighet förekommer PCP som en grundvattenförorening kring äldre sågverk. Hjortsberga i södra Sverige är ett exempel på denna typ av förorening och är det område som undersöks i arbetet. Förorenat grundvatten spridsPentachlorophenol (PCP) is a chlorinated aromatic compound that was commonly used for treatment of wood against microbial degradation before it got banned in the 1970s. Due to its solubility in water, PCP is a common groundwater contaminant around old sawmills, for example near Hjortsberga in southern Sweden where this study was performed.. The contaminated groundwater is spreading and leaking int

BdbD is a thiol: disulfide oxidoreductase (TDOR) from Bacillus subtilis that functions to introduce disulfide bonds in substrate proteins/peptides on the outside of the cytoplasmic membrane and, as such, plays a key role in disulfide bond management. Here we demonstrate that the protein is membrane-associated in B. subtilis and present the crystal structure of the soluble part of the protein lacki

The high-molecular-mass salivary mucin MG1, one of two major mucins produced by human salivary glands, plays an important role in oral health by coating the tooth surface and by acting as a bacterial receptor. Here this mucin was purified from the submandibular/sublingual saliva of a blood group O individual. The presence of MUC5B as the major mucin in this preparation was confirmed by amino acid

The World Meteorological Organization (WMO) Global Atmosphere Watch (GAW) coordinates high-quality atmospheric greenhouse gas observations globally and provides these observations through the WMO World Data Centre for Greenhouse Gases (WDCGG) supported by Japan Meteorological Agency. The WDCGG and the National Oceanic and Atmospheric Administration (NOAA) analyse these measurements using different

Forskargruppen studerar koordineringen av individuella handlingar i samhället, genom att analysera effekterna av formella och informella normer. Forskargruppen ägnar ett särskilt intresse åt de oavsiktliga eller oförutsedda konsekvenserna av regleringsåtgärder, utifrån perspektivet av samhället som en spontan ordning där alla beslut fattas under osäkerhet. Forskningen är ämnesövergripande och i The research group studies the coordination of individual actions in society by analysing the effects of formal and informal norms. The research group pays particular attention to the unintended or unforeseen consequences of regulatory measures, based on a view of society as a spontaneous order in which all decisions are made under conditions of uncertainty. The research is interdisciplinary and

Yvonne Lundberg Giwercman är forskargruppsledare för den här forskargruppenYvonne Lundberg Giwercman is Research Group Leader for this research group

Fotoreceptorerna - tappar och stavar - i ögats näthinna behövs för vår syn men är mycket sårbara, och sjukdomar kan göra att de degenererar och dör, vilket ger svår synnedsättning eller blindhet. En sådan sjukdom är Retinitis pigmentosa (RP), som drabbar ungefär 1 på 3000-4000 personer. RP-sjukdomen är ärftlig och beror på genmutationer, men det är oklart hur dessa får fotoreceptorerna att dö och The rod and cone photoreceptors in the retina of the eye are crucial for our vision, but also vulnerable to diseases, which can make them degenerate and die. Such diseases include Retinitis pigmentosa (RP), a heritable disease with a prevalence of about 1 in 3.000 – 4000 people. RP comes from gene mutations but it is not clear how these cause the degeneration and there are no therapies available.

Leukotriene ( LT) A(4) hydrolase is a bifunctional zinc metalloenzyme, which converts LTA(4) into the neutrophil chemoattractant LTB4 and also exhibits an anion-dependent aminopeptidase activity. In the x-ray crystal structure of LTA(4) hydrolase, Arg(563) and Lys(565) are found at the entrance of the active center. Here we report that replacement of Arg(563), but not Lys(565), leads to complete a

M1 aminopeptidases comprise a large family of biologically important zinc enzymes. We show that peptide turnover by the M1 prototype, leukotriene A4 hydrolase/aminopeptidase, involves a shift in substrate position associated with exchange of zinc coordinating groups, while maintaining the overall coordination geometry. The transition state is stabilized by residues conserved among M1 members and i

The X-ray structures of dUTPase from equine infectious anaemia virus (EIAV) in unliganded and complexed forms have been determined to 1.9 and 2.0 A resolution, respectively. The structures were solved by molecular replacement using Escherichia coli dUTPase as search model. The exploitation of a relatively novel refinement approach for the initial model, combining maximum likelihood refinement with

Effects of hydrogen bonding and the axial ligand interaction on the B800 band in two LH2 complexes Rhodopseudomonas (Rps.) acidophila and Rhodospirillum (Rs.) molischianum have been theo retically investigated by using density functional theory. The local electrostatic environment of the B800 bacteriochlorophyll is simulated as an atomic charge field consisting of the pigments in the protomer unit

Rat adipocyte cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) appears to be dually regulated in intact cells by serine phosphorylations induced by isoprenaline and insulin, respectively (Degerman, E., Smith, C. J., Tornqvist, H., Vasta, V., Belfrage, P., and Manganiello, V. C. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 533-537; Smith, C. J., Vasta, V., Degerman, E., Belfrage, P., and Manganiello, V.

https://www.geriatrik.lu.se/sites/geriatrik.lu.se/files/2025-10/Nyhetsbrev%20fra%CC%8An%20GA%CC%8AS-projektet%20december%202023.pdf - 2026-07-09

In the past two decades, the eddy covariance technique has been used for an increasing number of methane flux studies at an ecosystem scale. Previously, most of these studies used a closed path setup with a tunable diode laser spectrometer (TDL). Although this method worked well, the TDL has to be calibrated regularly and cooled with liquid nitrogen or a cryogenic system, which limits its use in r

Wildfires are a natural disturbance shaping boreal forests, but their effects on soil microbial communities and biogeochemical cycling remain unclear, particularly in Fennoscandia. We investigated the impact of fire severity and post-fire management on the soil microbial community two years after a boreal wildfire in Sweden. We quantified growth rates of bacteria, saprotrophic fungi (SF), ectomyco