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We have studied the binding of 102 ligands to the farnesoid X receptor within the D3R Grand Challenge 2016 blind-prediction competition. First, we employed docking with five different docking software and scoring functions. The selected docked poses gave an average root-mean-squared deviation of 4.2 Å. Consensus scoring gave decent results with a Kendall’s τ of 0.26 ± 0.06 and a Spearman’s ρ of 0.

The lack of any effective therapy along with the aging world population anticipates a growth of the worldwide incidence of Alzheimer's disease (AD) to more than 100 million cases by 2050. Accumulation of extracellular amyloid-β (Aβ) plaques, intracellular tangles in the brain, and formation of reactive oxygen species (ROS) are the major hallmarks of the disease. In the amyloidogenic process, a β-s

Microsoft Word - Litt.lista SPAA20 2022-06-10 Språk- och litteraturcentrum Spanska Litteraturlista SPAA32, Spanska, Fortsättningskurs, 31-60 högskolepoäng Fastställd av Styrelsen för Sektion 3 2024-11-21 att gälla från och med VT25. Delkurs 1. Litteratur, 7,5 hp Obligatorisk kurslitteratur Bombal, María Luisa. La amortajada. Valfri utgåva. (ca 100 s). Enríquez, Mariana. “El chico sucio”, “Tela de

https://www.sol.lu.se/media/utbildning/dokument/kurser/SPAA32/20261/SPAA32_Litt_HT25_1.pdf - 2026-06-04

In an aviary study, each of six male European Nuthatches Sitta europaea was allowed to hoard 30 sunflower seeds in natural hoarding substrates. After eight days, each bird was allowed to search for its cached seeds and its performance compared with that of a bird without previous experience of the specific aviary. In all but one case, the hoarder found significantly more seeds than did the naive b

While surgery is a cornerstone in treatment of peripheral nerve injuries, it is not a comprehensive approach, and outcome is unsatisfactory, especially sensory function. The present aim was to translate recent findings about stem- and progenitor cells to improve regenerative outcome, where the cells have to be autologous, available within the same surgical procedure, and minimally manipulated. Gra

Almost 30 years have passed since gender studies entered archaeological discourse in earnest. What is the current status of gender research? One of the aims with this book is to contribute to answering this and other related questions. Another is to shed some light on the pasts and possible futures of gender research.Contributions deal with publication statistics in journals over the last theirty

Localization of catechol-O-methyltransferase (COMT) in rat cerebral cortex, neostriatum and cerebellar cortex was studied with pre-embedding immunoelectron microscopy using a specific antiserum raised against rat recombinant COMT protein. In all areas, immunoreactivity was found both in astrocytes and in neuronal processes. Reaction product was seen in the cytoplasm and in association with tubular

BACKGROUND: The Xpert MTB/RIF Ultra (Xpert-Ultra) assay provides timely results with good sensitivity and acceptable specificity with stool specimens in children for bacteriological confirmation of tuberculosis (TB). This study aims to optimize the Simple One-Step (SOS) stool processing method for testing stool specimens using the Xpert-Ultra in children and adults in selected health facilities in

Severe extratropical winter storms are a recurrent feature of the European climate and cause widespread socioeconomic losses. Due to insufficient long-term data, it remains unclear whether storminess has shown a notable response to changes in external forcing over the past millennia, which impacts our ability to project future storminess in a changing climate. Reconstructing past storm variability

CO2 reduction reactions, which provide one route to limit the emission of this greenhouse gas, are commonly performed over Cu-based catalysts. Here, we use ambient pressure X-ray photoelectron spectroscopy together with density functional theory to obtain an atomistic understanding of the dissociative adsorption of CO2 on Cu(100). We find that the process is dominated by the presence of steps, whi

Methane is a powerful greenhouse gas and growing concern regarding global climate changes and landfill gas is regarded as one of the major sources for methane migration to the atmosphere. In this study we present research work with the objective to evaluate the use of 3D geoelectrical resistivity to detect gas migration in landfills. Extensive field experiments were conducted at the Filborna landf

A recently developed fully unconstrained approach to non-collinear magnetism has been applied to the investigation of the magnetic ground state of triangular free-standing Cr and Mn monolayers and overlayers on Cu(111) substrates. Such systems represent a physical realization of a frustrated two-dimensional antiferromagnet. We find that the ground state of the Cr monolayers is non-collinear; it sh

Safe water is a widespread problem in developing countries. In 2004 The United Nations formed the Lake Victoria Region Water and Sanitation Initiative, which focuses on increasing the water quality and basic sanitation in both rural- and urban areas. The government of Uganda is a part of the initiative, since the quality of the drinking water in the country persists to be a widespread problem. In

Introduction Prevalence of planned pregnancies varies between countries but is often measured in a dichotomous manner. The aim of this study was to investigate to what level pregnant women had planned their pregnancies and whether pregnancy planning was associated with background characteristics and pregnancy-planning behavior. Material and methods A cross-sectional study that utilized the baselin