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The well-known side effects of antimuscarinic drugs have focused interest on other modalities of treatment of the overactive bladder. To effectively control bladder activity, identification of suitable targets for pharmacologic intervention is necessary. Such targets may be found in the central nervous system (CNS) or peripherally. Several CNS transmitters may modulate voiding, but few drugs with

Biphasic insulin secretion is required for proper insulin action and is observed not only in vivo, but also in isolated pancreatic islets and even single beta-cells. Late events in the granule life cycle are thought to underlie this temporal pattern. In the last few years, we have therefore combined live cell imaging and electrophysiology to study insulin secretion at the level of individual granu

Schema för KURSNAMN 10 p (15 ECTS) VT -2 2003 Schema för GEOA01, 15 högskolepoäng (15 ECTS credits) HT-1 2016 Kursens namn: Planeten jorden – en introduktion Kursansvarig: Prof. Ulf Söderlund Lärare: PA = Prof. Per Ahlberg, HA = Prof. Helena Alexanderson, CA = Doc. Carl Alwmark, EA = Eva Andersson, SB = Prof. Svante Björck, MC = Prof. Mikael Calner, DH = Prof. Dan Hammarlund, AG = Doktorand Ashley

https://www.geologi.lu.se/sites/geologi.lu.se/files/geoa01_schema_2016-07-28.pdf - 2026-06-04

Abstract Plasmodium falciparum is the causative agent of the most serious and fatal malarial infections, and it has developed resistance to commonly employed chemotherapeutics. The de novo pyrimidine biosynthesis enzymes offer potential as targets for drug design, because, unlike the host, the parasite lacks pyrimidine salvage pathway.In search for new Plasmodium falciparum dihydroorotate dehydrog

Syftet med denna uppsats är att via en materialstudie få en förståelse för råmaterialets förändrade roll i samhället under övergångsperioden, senneolitikum 2300-1700 f.Kr. och bronsåldern period jag 1700-1500 f Kr. De teoretiska perspektiven inkluderar Giddens struktureringsteori teori och Annales-skolan. Materialet begränsas till delar av Malmöområdet eftersom det utgör ett område som varit föremThe purpose of this thesis was to study a material to gain an understanding of the changing role of raw materials in society during the transition period, Late Neolithic 2300-1700 BC and Bronze Age period I in 1700-1500 BC. Theoretical perspectives include Giddens structuration theory and the Annales-school. The material was limited to parts of the Malmö area because it is an area subject to numer

I denna studie analyseras Göteborgs kommuns miljödiplomeringsmodell, dess tillämpning,problem och möjligheter. Syftet var att studera vad företag och revisorer accentuerar på, vilka problem och brister som förekommer samt hur miljöprestanda och miljökommunikation uppfattas i certifierade respektive diplomerade företag. Ett annat syfte var att studera vilka orsakerna är bakom att en del diplomerade

The validity of a Swedish translation of the Measures of Criminal Attitudes and Associates (MCAA) was evaluated. All four subscales showed acceptable reliability, but the Entitlement scale can be improved by replacing items with low loadings. Confirmatory factor analysis supported a model with one common criminal attitude factor and three subfactors (corresponding to subscales of the test). The An

Many modern office buildings have highly glazed facades. Their energy efficiency and indoor climate is, however, being questioned. Therefore more and more of these buildings are being built with double skin facades, which can provide improvements: a thermal buffer zone, energy savings, wind protection with open windows, fire protection, aesthetics, solar preheating of ventilation air, sound protec

Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In blood it acts as a procoagulant, and, in the seminal vesicles, it is required for spermatogenesis. The activity of PCI is affected by heparin binding in a manner unique among the heparin binding serpins, and, in addition, PCI binds hydrophobic hormones with apparent specificity for retinoids. Here we

Free sodium metal clusters have been studied by probing the Na 2p core level using x-ray photoelectron spectroscopy (XPS) and Auger electron spectroscopy (AES). The development of electronic structure with size has been studied and discussed in comparison with the atom, dimer, and solid. Information on cluster metallic properties, size, and temperature has been deduced from the XPS measurements. F

The present communication reviews reasons to perform rescreening of chlamydia-infected persons. It brings up difficulties to differentiate between relapse and reinfection. Studies on follow-up of chlamydia-positive cases after therapy are reviewed. It also highlights reasons for therapeutic failure, like compliance, pharmacological factors, including poor bioavailability, wrong dose regimens, lack

Transgenically introduced laminin (LN) α1 chain prevents muscular dystrophy in LNα2 chain deficient mice. We now report increased integrin α7Bβ1D synthesis in dystrophic LNα2 chain deficient muscle. Yet, immunofluorescence demonstrated a reduced expression of integrin α7B subunit at the sarcolemma. Transgenic expression of LNα1 chain reconstituted integrin α7B at the sarcolemma. Expression of α- a

[Preliminary results from bryophyte spore capsule records in the county of Skåne, southernmost Sweden] Occurrences of sporophytes are recorded by inventorers within the bryophyte flora project for Skåne. Here we present commented distribution maps with sporophyte presence/absence indicated for Calliergonella cuspidata, Dicranum scoparium, Encalypta streptocarpa, Homalothecium sericeum, Hylocomium