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This paper provides one of the first studies on the role of social media in articulating individuals’ experiences and memories and (re-)shaping collective memory in contemporary China. It investigates how social media enable and facilitate the participation of ordinary citizens in distributing and accumulating alternative narratives and memories of the past against the authoritarian version by tak
We report on the identification and characterization of a mutated alcohol dehydrogenase 1 from the industrial Saccharomyces cerevisiae strain TMB3000 that mediates the NADH-dependent reduction of 5-hydroxymethylfurfural (HMF) to 2,5-bis-hydroxymethylfuran. The co-factor preference distinguished this alcohol dehydrogenase from the previously reported NADPH-dependent S. cerevisiae HMF alcohol dehydr
Addition of a 50 mM mixture of l-arginine and l-glutamic acid (RE) is extensively used to improve protein solubility and stability, although the origin of the effect is not well understood. We present Small Angle X-ray Scattering (SAXS) and Nuclear Magnetic Resonance (NMR) results showing that RE induces protein compaction by collapsing flexible loops on the protein core. This is suggested to be a
Abstract. We consider a of the forest fire model on graph G, where eachvertex of a graph becomes occupied with rate one. A fixed vertex v0 is hit by lightning with the same rate, and when this occurs, the whole cluster of occupied vertices containing v0 is burnt out. We show that when G = Z+, the times between consecutive burnouts at vertex n, divided by log n, converge weakly as n → ∞ to a random
Urate oxidase transforms uric acid to 5-hydroxyisourate without the help of cofactors, but the catalytic mechanism has remained enigmatic, as the protonation state of the substrate could not be reliably deduced. We have determined the neutron structure of urate oxidase, providing unique information on the proton positions. A neutron crystal structure inhibited by a chloride anion at 2.3 Å resoluti
The recently suggested possibility that weak vibronic transitions can be excitonically enhanced in light-harvesting complexes is studied in detail. A vibronic exciton dimer model that includes ground-state vibrations is investigated using the multi-configuration time-dependent Hartree method with a parameter set typical to photosynthetic light-harvesting complexes. The absorption spectra are discu
Abstract Heart failure is a common and disabling disease with high mortality that carries substantial societal costs. Current therapeutic strategies are aimed at relieving symptoms, avoiding hospitalization, and prolonging life, but disease progression is ultimately inevitable. MicroRNAs (miRNAs) are short, non-coding RNA molecules with pervasive roles in eukaryotic biology, annealing to complimen
Looking at two historical romances by women writers, Kathleen Graves’ Exile: A Tale of Old Tasmania (1945) and Isabel Dick’s Wild Orchard (1946), this article seeks to examine narratives of an early nineteenth-century Van Diemen’s Land that are apparently at odds with the 1940s Tasmania it was to become. Drawing on Giorgio Agamben’s “state of exception” as the theoretical underpinnings for this es
The ongoing ESA funded'SMOS + Vegetation' project combines a retrieval component that aims at further improving the SMOS VOD product with an assimilation component that aims at demonstrating the added value of this product in constraining simulated land surface fluxes of carbon dioxide. This contribution focuses on the project's modelling and assimilation component. We describe the construction of
Contemporary social and cultural conditions in Brazil, together with technological developments and social media have enabled more young people of the favela to participate in different spheres of public life. These social and cultural changes have brought diversified new images of what it means to be an embodied subject. In this article, I explore the ways in which the body holds a seemingly para
A gendered reading of the liberal peacebuilding and transitional justice project in Bosnia–Herzegovina raises critical questions concerning the quality of the peace one hopes to achieve in transitional societies. By focusing on three-gendered justice gaps—the accountability, acknowledgement, and reparations gaps—this article examines structural constraints for women to engage in shaping and implem
Enzymes with a protein kinase fold transfer phosphate from adenosine 5'-triphosphate (ATP) to substrates in a process known as phosphorylation. Here, we show that the Legionella meta-effector SidJ adopts a protein kinase fold, yet unexpectedly catalyzes protein polyglutamylation. SidJ is activated by host-cell calmodulin to polyglutamylate the SidE family of ubiquitin (Ub) ligases. Crystal structu
