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Molecular dynamics simulations, binding free energy calculations, principle component analysis (PCA), and residue interaction network analysis were employed in order to investigate the molecular mechanism of M184I single mutation which played pivotal role in making the HIV-1 reverse transcriptase (RT) totally resistant to lamivudine. Results showed that single mutations at residue 184 of RT caused

Background: Infantile neuroaxonal dystrophy (INAD) is a rare hereditary neurological disorder caused by mutations in PLA2G6. The disease commonly affects children below 3 years of age and presents with delay in motor skills, optic atrophy and progressive spastic tetraparesis. Studies of INAD in Africa are extremely rare, and genetic studies from Sub Saharan Africa are almost non-existent. Case pre

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/stade_b/Beata.txt - 2026-07-11

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_longitudinal/bror/Texte_3.txt - 2026-07-11

Detaljerade data är avgörande vid karaktärisering av komplexa förorenade områden. I denna studie utrustar vi ett antal G360-brunnssystem med Star-Oddi milli-TD-tryckgivare i ett mestadels PCE (tetrakloretylen)- och TCE (trikloretylen)-förorenat bostadsområde i Helsingborg. Trots att dessa tryckgivare vanligtvis används inom marina undersökningar gör deras kostnad samt kompakta storlek dem av intre

Cerebral pares (CP) är en diagnos som beskriver en heterogen grupp av individer som alla har någon grad av motorisk funktionsnedsättning. Utöver motorik är andra funktioner ofta också påverkade och komorbiditet (t.ex. epilepsi) samt s.k. ”secondary conditions” (t.ex. smärta) är vanliga. Personer med ryggmärgsbråck (MMC) har också motoriska problem, ofta tillsammans med problem relaterade till neurCerebral palsy (CP) is a medical diagnosis that describes a heterogeneous group of individuals who all have some degree of motor impairment. In addition to motor skills, other functions are often also affected and comorbidity (e.g., epilepsy) and secondary conditions (e.g., pain) are common. Individuals with spina bifida— and often more specifically myelomeningocele (MMC) — also have motor problem

MedCUL är Medicinska fakultetens Centrum för Undervisning och Lärande. Vi erbjuder kompetensutveckling inom undervisning och lärande. Vi verkar för att utformning av, beslut om och genomförande av utbildning ska vila på aktuellt internationellt kunskapsläge inom utbildningsområdet.MedCUL coordinates the faculty's quality assurance work at undergraduate level in cooperation with educational committees and program directors. We collaborate with teachers and educational leaders in developmental projects. Our research in medical education concerns areas related to our practice such as Problem Based Learning (PBL), workplace learning and supervision, PhD student supervision and

https://www.cec.lu.se/sites/cec.lu.se/files/2022-03/Adm%20Guide%202022%20English%20v2.xlsx - 2026-07-12

Planning and execution of large infrastructure projects benefit from detailed mapping of the subsurface through geophysical methods. However applying geophysical methods in an urban environment requires careful preparation to ensure success in areas where source of noise and present infrastructure may compromise the results. We present and discuss the results of a seismic investigation conducted i

It is a well-known fact that sustainable development goals are difficult to achieve without a proper water resources management strategy. This study tries to implement some state-of-the-art statistical and data mining models i.e., weights-of-evidence (WoE), boosted regression trees (BRT), and classification and regression tree (CART) to identify suitable areas for artificial recharge through flood

Heparan sulfate 3-O-sulfotransferase transfers sulfate to the 3-OH position of a glucosamine residue of heparan sulfate (HS) to form 3-O-sulfated HS. The 3-O-sulfated glucosamine residue contributes to two important biological functions of HS: binding to antithrombin and thereby carrying anticoagulant activity, and binding to herpes simplex viral envelope glycoprotein D to serve as an entry recept

The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA