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This collection of essays explores the remarkable range and cultural significance of the engagement with 'infancy' during the Romantic period. Taking its point of departure in the commonplace claim that the Romantics invented childhood, the book traces that engagement across national boundaries, in the visual arts, in works of educational theory and natural philosophy, and in both fiction and non-
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we ide
gamma -Carboxylated proteins were detected in normal human pancreas by immunohistochemistry with a monoclonal antibody (M3B) specific for gamma -carboxyglutamyl residues, Staining appeared to be localized to the glucagon-secreting alpha -cells in the islets of Langerhans, Consistent with this, sections from a glucagonoma were stained much more intensely with the M3B antibody than those from an ins
Coronary disease risk increases inversely with high-density lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a technical challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the majo
Understanding the mechanisms governing chemical and morphological changes induced by an ambient-pressure gas and how such changes influence the activity of heterogeneous catalysts is central to the formation of a predictive capability for structure-reactivity relationships. With techniques such as ambient-pressure photoelectron spectroscopy, scanning tunneling microscopy, and surface X-ray diffrac
Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity. TERT expression is mostly repressed in somatic cells with exception of proliferative cells in self-renewing tissues and cancer. Immortality associated with cancer cells has been attributed to telomerase over-expression. The precise mechanism behind the TERT activa
This paper examines how material and emotional investments in childrearing are rendered culturally meaningful in Chinese middle-class families in Singapore, and its consequences for family life. The competitive education system is a major concern for families with young children, and parents often invest substantial resources and energy in their children’s upbringing. The ‘overburdening’ of middle
Requirements on well documented management systems for Nuclear Power Plants (NPPs) are relatively new and in different developmental phases. Thus there is a need of knowledge about well-functioning Safety Management Systems (SMSs) also considering other goals and restrictions. Since there ia a lack of mature management systems for NPPs it is important to learn from other NPPs, but also from other
The enlargement of the European Union provides opportunities for members to be mobile in seeking various forms of permanent and non-permanent employment, particularly temporary work and contract labour. These changing conditions require quick reactions, overcoming soft issues such as language barriers and coping with culture clashes and political issues that could create problems for the worker. W
We have investigated the geometry and electronic structure of two different types of self-aligned silicon nanoribbons (SiNRs), forming either isolated SiNRs or a self-assembled 5 x 2/5 x 4 grating on an Ag(110) substrate, by scanning tunnelling microscopy and high resolution x-ray photoelectron spectroscopy. At room temperature we further adsorb on these SiNRs either atomic or molecular hydrogen.
In the circuits of culture there are a multitude of representations in circulation. These representations are derived from a range of media products such as guidebooks and tourist brochures. Furthermore, these media products and representations continuously converge with each other. The question, then, is what representations are contained within these converged media products. This article theref
JavaScript is a dynamically typed, object-based scripting language with runtime evaluation. It has emerged as an important language for client-side computation of web applications. Previous studies indicate some differences in execution behavior between established benchmarks and real-world web applications. Our study extends previous studies by showing some consequences of these differences. We c
The mid-Holocene Littorina transgression in southern Scandinavia is well documented. Multiple-stratigraphic sequences in ancient Littorina lagoons in the coastal area of Blekinge, SE Sweden reveal a maximum relative sea level of 7-8 m above present sea level between 8000-6000 cal. BP. Evidence for at least two transgression waves is found within this period. In this study these are documented in o
Whilst concurring with the new streams of literature in geography that highlight the importance of face-to-face and ‘buzz’ in the globalizing learning economy, we argue that this literature is misleading on three interrelated counts. Firstly, it conflates face-to-face and buzz; secondly, it fails to distinguish between the importance of face-to-face and buzz for industries drawing on different kno
