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It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spanned by TCR-ligand complexes, implying t

SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by microscopy analyses, aggregation and gel shift assays. LPS at high levels boosts the formation of S protein aggregates as detected by amytracker and thiofl

The widely investigated oxygen reduction reaction (ORR) is well-known to proceed via two competing routes, involving two or four electrons, and yielding different reaction products, respectively. Both pathways are believed to share a common, elusive intermediate, namely, the hydroperoxyl radical. By exploiting a cobalt single-atom biomimetic model catalyst, based on a self-assembled monolayer

Carbapenem resistance caused by metallo-β-lactamases is a serious global challenge that, if not tackled efficiently, is expected to lead to millions of deaths in the coming decades. Verona-integron encoded metallo-β-lactamase 2 (VIM-2) is a bacterial enzyme that has been reported from multidrug-resistant nosocomial isolates of Pseudomonas aeruginosa and other Gram-negative pathogens. As it hydroly

The high performance of platinum-Tin catalysts for oxidation reactions has been linked to the formation of tin oxides at the metal surface, but little is known about the structure of these oxides or the chemical behavior that determines their catalytic properties. We show here how surface oxides on Pt3Sn(111) incorporate oxygen at the metal interface, which may be subsequently removed by reaction

Photovoice is an increasingly popular research method across disciplines due to its flexibility and capacity for generating rich data. This article argues that while its practical virtues are abundant, the theoretical contributions of photovoice to qualitative research are just as important. We argue that photographs can act as boundary objects that enable collective sensemaking at multiple stages

Abstract in Thaiชาวจีนจำนวนมากเดินทางเข้ามายังเดลี-เมดานในช่วงศตวรรษที่ 19 ในฐานะแรงงานสัญญาจ้างเพื่อพัฒนาเขตเกษตรกรรมของดัตช์บนเกาะสุมาตราโดยเฉพาะบริเวณตะวันออกของสุมาตราเหนือครอบคลุมพื้นที่ของเดลี เซอดัง (Deli-Serdang) และเมืองเมดาน (Medan) ในปัจจุบัน พื้นที่ดังกล่าวถูกพัฒนาขึ้นให้กลายเป็นพื้นที่เกษตรกรรมสมัยใหม่ มีการเพาะปลูกพืชหลายชนิด โดยพืชเศรษฐกิจที่สำคัญที่สุดในพื้นที่ขณะนั้น คือ ใบยาสูบ ซIn the 19th Century, Deli-Medan received a large number of Chinese migrants. Most of them worked as labourers in Dutch agricultural plantations on the east coast of Sumatra, extending from Deli-Serdang to Medan. The agricultural products, such as tobacco, were intentionally developed and eventually became the most exportedproducts of Sumatra. As these economic activities paved the way for economic

The objective of this study was to evaluate the influence of operational conditions and wastewater properties on the removal of pharmaceuticals, contrast media and antibiotics through ozonation, in order to facilitate the optimization of treatment and its implementation on a full scale. Pilot-scale ozone oxidation trials were performed on treated wastewater, before and after post-precipitation, ov

A predictive understanding of soft x-ray near-edge absorption spectra of small molecules is an enduring theoretical challenge and of current interest for x-ray probes of molecular dynamics. We report the experimental absorption spectrum for the electron spectroscopy for chemical analysis (ESCA) molecule (ethyl trifluoroacetate) near the carbon 1s absorption edge between 285-300 eV. The ESCA molecu

H-kininogen (high-molecular-mass kininogen, HK) is the precursor of the vasoactive peptide hormone bradykinin (BK). Previous work has demonstrated that HK binds to Streptococcus pyogenes through M-proteins, fibrous surface proteins and important virulence factors of these bacteria. Here we find that M-protein-expressing bacteria absorb HK from human plasma. The HK bound to the bacteria was found t

New guidelines on care in dementia from the Swedish National Board of Health and Welfare emphasize that brain imaging should be included in the standard diagnostic evaluation. Evidence supports the importance of regional/global atrophy and white matter changes in dementia. However, the use of imaging in dementia evaluation is often sub-optimal, urging optimization of clinical imaging practice. Ima