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Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades are known to modify actin at Arg177; but of the 14-3-3 dependent exotoxins only Aeromonas salmonicida exoenzyme T (AexT) has been reported to ADP-ribosylate actin. Given the extensive similarity among the 14-3-3 dependent exotoxins, we initi

Conventional fixation of large solid surgical specimens is a slow process. Consequently, autolytic damage to tissues may occur if the fixative does not reach the central part of the specimen in time. However, as there is also a time relationship between formalin fixation and antigen masking, fixation for too long can also be detrimental. In seeking the optimum balance for fixation, microwave irrad

Time-resolved analysis of photon cross-correlation function g(2)(τ) is applied to photoluminescence (PL) of individual submicrometer size MAPbI3 perovskite crystals. Surprisingly, an antibunching effect in the long-living tail of PL is observed, while the prompt PL obeys the photon statistics typical for a classical emitter. We propose that antibunched photons from the PL decay tail originate from

Ethnomethodology research has systematically investigated discursive practices of categorisation, looking at the various ways by which social actors ascribe both themselves and others to identity categories to accomplish various kinds of social actions. Drawing on a data corpus of oncological visits collected in an Italian hospital, involving both native and non-native patients, the present work a

South Korea and Singapore have established a reputation as top performers in international student assessment tests and rankings, which is usually understood to be the result of competitive education systems and a distinct parenting culture. They also share a large private tuition industry, fueled by parents’ anxiety over their children’s academic achievements and future. In an attempt to contest South Korea and Singapore have established a reputation as top performers in international student assessment tests and rankings, which is usually understood to be the result of competitive education systems and a distinct parenting culture. They also share a large private tuition industry, fueled by parents’ anxiety over their children’s academic achievements and future. In an attempt to contest

This article examines the records of the so-called homo-sex commission—a part of the municipal Stockholm police force dedicated to the policing of male same-sex practices—as a case study of the role of policing in shaping historical understandings of homosexuality. Building on a series of documents left by the commission and high-ranking police officers, from memoranda describing the nature of hom

There are many definitions of resilience, but in general it refers to the ability of a system, which may be a community, society, or economic system that are exposed to extreme disturbances, persistent stress, or hazards to resist, absorb, accommodate, adapt to, transform and recover from effects of the situation in a timely and efficient manner (PreventionWeb n.d.;). Sustainability is focused on

Maritime archaeology excavations, even in a more complex environment, have the same objectives and requirements as terrestrial ones: documenting digging operations to analyze data in the best way, interpreting it, and producing new knowledge for the benefit of multiple communities. 3D documentation and management methodologies have spread widely among practitioners; however, 3D comprehensive tools

Marine copepods, the most abundant animals in the global ocean, imprint their surrounding waters with chemical cues, called copepodamides. Copepodamides induce defensive traits such as toxin production, bioluminescence, and colony size plasticity in a variety of marine phytoplankton. The role of copepodamides in freshwater ecosystems is, however, unknown. Here we report the consistent presence of

This article applies an agenda-setting approach to the impact of New Public Management on health-care reform in Sweden and Finland (1993–2016). A system-level view of agenda setting and New Public Management implementation is used to order the historical data derived from literature reviews of each health reform process. New Public Management is viewed as a hybrid concept rooted in the search for

We show that the alkylating cancer drug melphalan activated the DNA damage response and induced human papillomavirus type 16 (HPV16) late gene expression in an ATM- and Chk1/2-dependent manner. Activation of HPV16 late gene expression included inhibition of the HPV16 early polyadenylation signal that resulted in read-through into the late region of HPV16. This was followed by activation of the exc

We present the first experimental study of the frontier orbitals in an ultrathin film of the novel hexa-carbene photosensitizer [Fe(btz)3]3+, where btz is 3,3′-dimethyl-1,1′-bis(p-tolyl)-4,4′-bis(1,2,3-triazol-5-ylidene). Resonant photoelectron spectroscopy (RPES) was used to probe the electronic structure of films where the molecular and oxidative integrities had been confirmed with optical and X

This study has examined Liberian disabled women’s participation in peace and security processes through the lens of the United Nations Security Council Resolution (UNSCR) 1325. The aim was to gain new insights into Liberian disabled women’s experience in peace and security processes, since the overarching research problem is the lack of insight into the disabled women’s experiences as participants

Optimized biogenic carbon fluxes for Europe wereestimated from high-resolution regional-scale inversions, uti-lizing atmospheric CO2measurements at 16 stations for theyear 2007. Additional sensitivity tests with different data-driven error structures were performed. As the atmosphericnetwork is rather sparse and consequently contains large spa-tial gaps, we use a priori biospheric fluxes to