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The biothiols sensing mechanism of (E)-7-(diethylamino)-3-(2-nitrovinyl)-2H-chromen-2-one (DCO) has been investigated using the density functional theory (DFT) and time-dependent DFT methods. The theoretical results indicate that the excited-state intermolecular hydrogen bonding (H-B) plays an important role for the biothiols sensing mechanism of the fluorescence sensor DCO. Multiple H-B interacti
Activation of thrombin is a critical determinant in many physiological and pathological processes including haemostasis and inflammation. Under physiological conditions many of these functions are involved in wound healing or eradication of an invading pathogen. However, when activated systemically, thrombin can contribute to severe and life-threatening conditions by causing complications such as
Psykiskt störda lagöverträdare har ofta inte samma förutsättningar som andra att följa lagen då de kan ha en annan föreställning av, eller en annan förmåga att resonera kring, verkligheten. Det är vår föreställning av verkligheten som ger oss skäl att göra eller att inte göra vissa saker, och vår uppfattning om vilka följder vårt handlande kommer att få, får betydelse för om vi företar handlingen Mentally disordered offenders often do not have the same preconditions as others to follow the law as they may have a different perception of, or a different ability to reason about, reality. It is our perception of reality that gives us reason to do or not do certain things, and our perception of the consequences our actions will have has an impact on whether we undertake them or not. If you have
The number of companies that are discovering the benefits of having a process-oriented mindset is continually increasing. But moving from having a strict functional-oriented mindset to becoming more process-oriented does not happen over night. The road of transformation is long and many challenges are faced on the way. This thesis focuses on the question of how companies should approach a transfor
Researchers and practitioners have recognized the need for ‘transforming’ every policy of the company into a competitive advantage tool. Thus, both the pricing approach and the supply chain practices of the firm have emerged as an important determinant of success. In this study, however, we are not only interested in these two aspects, but also in a third one-namely cultural conflicts as an obstac
Proliferation, differentiation, and survival of hematopoietic cells are regulated by cytokines, acting through specific receptors. FLT3 ligand (FL) is one of the most important cytokines for regulation of the hematopoietic system, and its receptor FLT3 is expressed on both stem cells and progenitors. Regulation of Forkhead transcription factors has been described as an important mechanism to contr
Activated coagulation factor V (FVa) functions as a cofactor to factor Xa (FXa) in the conversion of prothrombin (PT) to thrombin. This essential procoagulant reaction, despite being the subject of extensive investigation, is not fully understood structurally and functionally. To elucidate the structure of the FXa-FVa complex, we have performed protein:protein (Pr:Pr) docking simulation with the p
This paper is about the recent discussions (known as Denkmalpflegediskussion) on the general organization of heritage management in Germany. The main issue discussed was whether heritage management should be further denationalized (’entstaatlicht’) and made the responsibility of individual citizens in order to serve better both the monuments and the people. A number of fundamental criticisms were
Adsorption of 0.2 ML Na on Al(1 0 0) at room temperature yields a disordered Al(1 0 0)-(1 x 1)-Na phase, which transforms reversibly to a well-ordered Al(1 0 0)-(root5 x root5)R27degrees-Na phase on cooling below 250 K. Based on low energy electron diffraction (LEED) and high resolution core-level spectroscopy (HRCLS) measurements, and on ab initio calculations, it is concluded that the structure
Bygg- och fastighetssektorn stod år 2020 för ungefär en tredjedel av Sveriges totala energianvändning, där energianvändningen främst består av energi för uppvärmning. Energibesparingar på en byggnads uppvärmningsenergi kan göras med hjälp av tekniska åtgärder och genom förändring av brukarvanor. Det finns i dagsläget ett gap mellan den förväntade och faktiska energianvändningen i byggnader. Detta The aim of this report is to study occupants’ behavior to investigate the impact occupants’ behaviors, with an extra focus on different window opening behaviors, has on the total annual energy use in an apartment building. Other behaviors that are included in the study are use of household electricity, hot water use, and indoor temperature. The study will be performed as a literature study combine
