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The classical pathway of complement is crucial to the immune system, but it also contributes to inflammatory diseases when dys-regulated. Binding of the C1 complex to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activates C1s. C1s cleaves complement component C4 and then C2 to cause full activation of the system. The interaction between C1s and C4 inv

Blood cell formation, or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical differentiation process that results in the production of mature effector blood cells. Aging is characterized

The aim of this study is to increase the knowledge in practice of value co‐creation by providing information on how co-creation is manifested in C-­‐G lookbook. This thesis employs a qualitative strategy with an inductive approach, and data were collected through virtual observation. Theoretical framework is divided into three different parts, in which various theories within s

A computational method is described and tested for prediction of ligand-binding poses between the human farnesoid X receptor and a set of 36 potential agonists, provided by the D3R Grand Challenge 2016. Using tools such as Molecular Docking, Molecular Dynamics, Reconnaissance metadynamics and cluster analysis, the method is an attempt to predict the binding pose without being biased by experimenta

Wildlife crossing structures are needed to enable animal movements in an all more broken up landscape. The Swedish Transport Administration need to know how to build these. Previous studies have focused on passing frequencies and indices. Few have looked at the behavior of the visiting animals. In this study, I have complemented passage frequencies with vigilance behavior for roe deer and fallow d

This study has examined Liberian disabled women’s participation in peace and security processes through the lens of the United Nations Security Council Resolution (UNSCR) 1325. The aim was to gain new insights into Liberian disabled women’s experience in peace and security processes, since the overarching research problem is the lack of insight into the disabled women’s experiences as participants

The Cold War shaped the Danish landscape and cityscape profoundly. Numerous bunkers, military and civilian remain today as testimonies of a time where fear of a nuclear Third World War was imminent. This chapter delves into “the bunker” as materiality and myth, drawing inspiration from bunker studies from a broad range of fields including history, geography and architecture. Subsequently, this cha

PROBLEM: The embryo is protected from immunologic rejection by the mother, possibly accomplished by immunosuppressive molecules located in the placenta. We investigated the distribution and biochemical properties in placenta of the immunosuppressive plasma protein alpha 1-microglobulin.METHOD OF STUDY: Placental alpha 1-microglobulin was investigated by immunohistochemistry and, after extraction,

We show that the alkylating cancer drug melphalan activated the DNA damage response and induced human papillomavirus type 16 (HPV16) late gene expression in an ATM- and Chk1/2-dependent manner. Activation of HPV16 late gene expression included inhibition of the HPV16 early polyadenylation signal that resulted in read-through into the late region of HPV16. This was followed by activation of the exc

The Mo/Cu-dependent CO dehydrogenase from O. carboxidovorans is an enzyme that is able to catalyse CO oxidation to CO2; moreover, it also expresses hydrogenase activity, as it is able to oxidize H2. Here, we have studied the dihydrogen oxidation catalysis by this enzyme using QM/MM calculations. Our results indicate that the equatorial oxo ligand of Mo is the best suited base for catalysis. Moreov

We present the first experimental study of the frontier orbitals in an ultrathin film of the novel hexa-carbene photosensitizer [Fe(btz)3]3+, where btz is 3,3′-dimethyl-1,1′-bis(p-tolyl)-4,4′-bis(1,2,3-triazol-5-ylidene). Resonant photoelectron spectroscopy (RPES) was used to probe the electronic structure of films where the molecular and oxidative integrities had been confirmed with optical and X

Genetic factors are often overlooked in conservation planning, despite their importance in small isolated populations. We used mitochondrial and microsatellite markers to investigate population genetics of the adder (Vipera berus) in southern Britain, where numbers are declining. We found no evidence for loss of heterozygosity in any of the populations studied. Genetic diversity was comparable acr