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EWSR1 is involved in chimeric proteins which play crucial roles in the development of a variety of bone and soft tissue tumors. Many of the chimeric genes involving EWSR1 have been extensively studied, whereas less is known about the wild-type (wt) gene and its regulation. As the expression of the chimeric gene is driven by the EWSR1 promoter, it is of importance to study the mechanisms regulating
Calcitonin gene-related peptide (CGRP) is expressed throughout the CNS and peripheral nervous system, consistent with control of vasodilatation, nociception, motor function, secretion and olfaction. alphaCGRP is prominently localized in primary afferent C and Adelta fibres of spinal and trigeminal ganglia. Activation of the trigeminal nerve results in antidromic release of CGRP, acting through a C
This chapter explores how Danish animal rights activists challenge the commodification of female bodies, particularly in dairy production, through narratives of motherhood and care. It examines how activists attempt to educate the public—not only by providing information about how dairy is produced but also by offering alternative frameworks from which to think about human-cow relations. Based on
Atmospheric inversions are widely used to evaluate and improve inventories of methane (CH4) emissions across scales from global to local, combining observations with atmospheric transport models. This study uses the dense network of in situ stations of the Integrated Carbon Observation System (ICOS) to explore how well in situ data can constrain European CH4 emissions. Following the concept of int
Understanding the genetic regulation of blood CD34+ cell levels could lead to better methods for stem cell mobilization and transplantation. Recently, in a genome-wide association study (GWAS), we identified 11 genetic associations with blood CD34+ cell levels. One of the most significant maps to an intergenic region between the ENO1 and RERE genes at chromosome 1p36.23. However, the underlying me
The link between regional tau load and clinical manifestation of Alzheimer's disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progression of tau pathology mirrors the functional connections from temporal lobe epicentres. However, given the limited spatial heterogeneity of tau in typical AD, at
The relationship between a physiological index called the photochemical reflectance index (PRI) and photosynthetic light-use-efficiency (LUE) of a Siberian boreal forest during the winter–spring transition, or green-up period, was investigated in 2000. During this time the photosynthetic apparatus was considered under stress as a result of extremes of temperature (from −20 to 35 °C) coupled with a
About one in ten persons is born with, or develops, a physical, sensory or mental impairment. When this stops a person from participating in normal life, it becomes a handicap. The aim of this Building Issue is to help create physical environments, particularly in public buildings, that support people with physical and sensory impairments, so that they do not become handicapped. This report identi
Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of l-histidine, which is catalyzed by pyridoxal-5'-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). The limited availability and stability of the protein have delayed the characterization of its structure-function relationships. Ou
Galectin-1, beta-galactoside binding lectin involved in immunoregulation and cancer, binds natural and many synthetic multivalent glycoconjugates with an apparent glycoside cluster effect, that is, affinity above and beyond what would be expected from the concentration of the determinant sugar. Here we have analyzed the mechanism of such cluster effects in solution at physiological concentration u
We investigate the temperature dependence of the O-H stretch band in the infrared absorbance spectra of the proton-conducting hydrated perovskites BaInxZr1-xO3-x/2 (x = 0.10-0.75) over the temperature range -160 to 350 degrees C. Upon increasing temperature from -160 to 30 degrees C, we show that there is a redistribution of protons from nonsymmetrical structural configurations, such as Zr-OH-In a
Knowledge of subcellular localizations (SCLs) of plant proteins relates to their functions and aids in understanding the regulation of biological processes at the cellular level. We present PlantLoc, a highly accurate and fast webserver for predicting the multi-label SCLs of plant proteins. The PlantLoc server has two innovative characters: building localization motif libraries by a recursive meth
During a period of 40 years in the second half of the 17th century, a process of industrialization was initialized in the northern part of the Torne River valley, northern Sweden. The industrialization was the result of global demand for copper and brass, but its practice was a local and regional encounter between different groups of people with a manifold of identities, languages, e
Verksamhetsberättelse 2018 Verksamhetsberättelse 2018 Körcentrum Syd Musikhögskolan i Malmö Lunds universitet Inledning Nedanstående verksamhetsberättelse för år 2018 har fastställts av Körcentrum Syds styrelse, 2019-01-21. Körcentrum Syd är en centrumbildning inrättad av Lunds Universitet. I Körcentrum Syds styrelse var följande institutioner representerade under 2018: Lunds Universitet med Musik
https://www.korcentrumsyd.lu.se/sites/korcentrumsyd.lu.se/files/verksamhetsberattelse_2018_korcentrumsyd.pdf - 2026-07-13
Maritime archaeology excavations, even in a more complex environment, have the same objectives and requirements as terrestrial ones: documenting digging operations to analyze data in the best way, interpreting it, and producing new knowledge for the benefit of multiple communities. 3D documentation and management methodologies have spread widely among practitioners; however, 3D comprehensive tools
