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Ferrochelatase catalyzes the metallation of protoporphyrin IX in the terminal step of heme biosynthesis. Mutations in the ferrochelatase gene can lead to the disease erythropoietic porphyria. The catalyzing mechanism of ferrochelatase is still not fully understood. In this paper, we have studied the insertion of Fe2+ into the protoporphyrin IX ring by Bacillus subtilis ferrochelatase using combine
Biochemical reactions powered by ATP hydrolysis are fundamental for the movement of molecules and cellular structures. One such reaction is the encapsidation of the double-stranded DNA (dsDNA) genome of an icosahedrally symmetric virus into a preformed procapsid with the help of a genome-translocating NTPase. Such NTPases have been characterized in detail from both RNA and tailed DNA viruses. We p
The concept of neutrophil activation and degranulation as important contributors to disease pathology in invasive group A streptococcal infections has recently been emphasized. This study focuses on two of the most severe streptococcal manifestations, toxic shock syndrome and necrotizing fasciitis, and the newly described proinflammatory molecule resistin, known to derive from adipocytes and monoc
Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription factor closely related to PU.1 and SPI-B, and expressed temporarily during B-cell
The mechanical integrity of tin-doped indium oxide (ITO) thin films sputtered onto a high temperature aromatic polyester developed for flexible display applications was investigated by means of tensile experiments equipped with electrical measurement, and carried out in-situ in an optical microscope. Attention was paid to the influence of ITO thickness, composition and crystalline microstructure,
The title compound, lithium potassium dialuminium diger-manium octaoxide dihydrate, (K,Li)-(Al,Ge)-GIS (GIS is gismondine), is the result of a 50% Li+ exchange into the K-(Al,Ge)- GIS structure. The (K,Li)-(Al,Ge)-GIS structure was determined from a 4 x 4 x 2 m m octahedral single crystal at the ESRF synchrotron X-ray source. The ion exchange results in a symmetry transformation from I2/a for K-(A
Visits to nest holes by birds other than their owners is a familiar phenomenon for students of breeding biology. In this study, we evaluate that behavior using a transponder reading system. Eighty-five males and females were Fitted with transponders at the end of the incubation period or just after hatching. Nest boxes were fitted with transponder readers from just after hatching until all nestlin
Pedagogical practice is, in several important considerations, contradictory in character. In this dissertation attenention is drawn towards the field of tension that prevails between pedagogical action, which can be descibed in terms of strategic processes and communicative pedagogical action. While the former places the preconditions for effective knowledge development of the individual at the ce
The affinity and enantioselectivity have been determined for designed propranolol derivatives as ligands for Cel7A by capillary electrophoresis (CE) at pH 7.0. These results have been compared to measurements at pH 5.0. In agreement with previous studies, the affinity increased at the higher pH. However, the affinity was not as dependent of the ligand structure at pH 7.0 as at pH 5.0, and the sele
The conventional inversion of surface waves depends on modal identification of measured dispersion curves, which can be ambiguous. It is possible to avoid mode-number identification and extraction by inverting the complete phase-velocity spectrum obtained from a multichannel record. We use the fast simulated annealing (FSA) global search algorithm to minimize the difference between the measured ph
Intranät och Web 2.0 är två aktuella ämnen och syftet med uppsatsen är att se om funktioner som tillskrivs Web 2.0 kan användas i intranät för att förmedla och hantera kunskap. Uppsatsens problemområde begränsas till att enbart innefatta funktionaliteter i intranät och inte de organisatoriska förutsättningar dessa funktioner kan kräva. Arbetet strukturerades runt litteraturstudier i ämnet samt en
This study examined the correlation between romantic attachment and representations of caregiving. The participants were 56 parents whose oldest child was between the age of 1 and 6 years old and whose relationship with their partner had lasted for 2 years or more. Half of the participants were interviewed with Caregiving and Attachment Interview (CAI), a semistructured interview regarding their r
The occurrence of astragali, knuckle-bones, in the Mediterranean world has been observed for a long time. Despite this, the distribution of astragali in the western Mediterranean has been somewhat overlooked. This paper aims to create an overview of the occurrence of astragali, knuckle-bones, in burial contexts in Magna Graecia. To do so, four places in Calabria and Sicily with different relations
This paper examines Pixar Animation Studios’ movies Ratatouille (2007), WALL-E (2008), and Soul (2020) to explore whether and how they sacralize ordinary actions, thereby transforming films into places of ritualistic meaning-making. Using ritual theory (Grimes, Bell, Turner), Paul Schrader’s transcendental style, and the framework of cine-ritualism, the study explores how audio-visual strategies c
Denna analys undersöker hur Sonys animerade Spider-Verse filmer använder sig av multiversumberättande för att vidga och utforska vem som får vara Spider-Man. Karaktären och superhjältegenren i sin helhet har länge främst representerat ljushyade amerikanska män, men Spider-Verse bevisar genom sin mångfald av Spider-Personer av olika etniciteter, nationaliteter, könsidentiteter samt visuella stilar This analysis examines how Sony's animated Spider-Verse films use multiverse storytelling to expand and explore who gets to be Spider-Man. The character and the superhero genre as a whole have long primarily represented white American men, but Spider-Verse proves through its diversity of Spider-People of different ethnicities, nationalities, gender identities and visual styles that anyone can
Out of Time? is an empirical study in environmental temporalities. With a geographic focus on Greater Manchester in the United Kingdom (UK), this paper addresses how this specific locality – characterised by a rich history of workers’ struggle, industry and, more recently, climate action – displays features of the concept of “fatal confusion” brought into the academic discourse by Michelle Bastian
