Filtyp
Bioprocess monitoring and control is a complex task that needs rapid and reliable methods which are adaptable to continuous analysis. Process monitoring during fermentation is widely applicable in the field of pharmaceutical, food and beverages and wastewater treatment. The ability to monitor has direct relevance in improving performance, quality, productivity, and yield of the process. In fact, t
The thesis deals with circuit-level aspects of CMOS buffer SRAMs where the data throughput rate is a more important metric than access time or storage capacity. One aspect is the increased write cycle related power consumption that is the consequence of a high write ratio combined with a long word-length. That is addressed through the invention of a new bit-line operation mode which allows lower
This paper introduces means for fatigue damage rates estimation using Laplace distributed multiaxial loads. The model is suitable for description of stresses containing transients of random amplitudes and locations. Explicit formulas for computing the expected value of rainflow damage index as a function of excess kurtosis are given for correlated loads. A Laplace model is used to describe variabi
Gemcitabine has been the standard chemotherapeutic agent in pancreatic cancer. However, two-thirds of pancreatic tumors display low expression of human equilibrative nucleoside transporter 1 (hENT1), which mediates cellular entry of the drug, and do not respond to gemcitabine therapy. The objective was to determine the costs of gemcitabine overtreatment and the cost-effectiveness of hENT1 testing
The development of new therapies for the treatment of type 2 diabetes requires robust, reproducible and well validated in vivo experimental systems. Mice provide the most ideal animal model for studies of potential therapies. Unlike larger animals, mice have a short gestational period, are genetically similar, often give birth to many offspring at once and can be housed as multiple groups in a sin
As a consequence of the municipality reform and the consequent move of services from hospital to primary healthcare, a Danish municipal wished to strengthen the professional competences, fellow-feeling, and collegiate spirit of their community nurses, taking their starting point in their newly developed ‘profile for community nurses’. This article presents a concept for reflection on practice whic
Inresource-constrained systems, the interference generated by the concurrent execution of multiple controller tasks leads to extra delay and jitter, which degrade control performance and may even jeopardize the stability of the controlled system. This work presents a general methodology that integrates control issues and real-time schedulability analysis to improve the control performance in embed
CO2 fluxes for the Netherlands and surroundings are estimated for the year 2008, from concentration measurements at four towers, using an inverse model. The results are compared to direct CO2 flux measurements by aircraft, for 6 flight tracks over the Netherlands, flown multiple times in each season. We applied the Regional Atmospheric Mesoscale Modeling system (RAMS) coupled to a simple carbon fl
This report identifies a set of policy lessons for China today drawn from the experience of financial deregulation, financial crisis, and recovery in Scandinavia during the period 1985-2000. Although there are considerable differences between the huge Chinese economy and the small Nordic countries, there are enough similarities to make lesson-drawing a worthwhile exercise. Based on the Scandinavia
Attenuation-based tomosynthesis has proven to successfully resolve the glandular tissue overlap present in mammography. However, the ability of tomosynthesis to differentiate tumorous and glandular tissue remains limited, due to the small differences in X-ray attenuation in breast tissue. One possibility to overcome this limitation and to further increase the diagnostic value of tomosynthesis exam
This paper describes the problem of load disturbance rejection using feedforward for the case when perfect compensation is not realizable due to processes delays inversion. First, a new generalized open-loop design tuning rule for feedforward compensators is proposed. Simple and intuitive guidelines are given for aggressive, moderate, and conservative performance results. Moreover, a switching fee
We obtain new results on Fourier multipliers for Dirichlet-Hardy spaces. As a consequence, we establish a Littlewood-Paley inequality, and we give a simple proof that the Dirichlet monomials form a Schauder basis for p>1.
The 4th Haemophilia Global Summit was held in Potsdam, Germany, in September 2013 and brought together an international faculty of haemophilia experts and delegates from multidisciplinary backgrounds. The programme was designed by an independent Scientific Steering Committee of haemophilia experts and explored global perspectives in haemophilia care, discussing practical approaches to the optimal
Early prediction of severe acute pancreatitis (SAP) substantially improves treatment of patients. A large amount of biomarkers have been studied with this objective. The aim of this work was to study predictive biomarkers using preset cut-off levels in an unselected population of patients with acute pancreatitis (AP).
Idiopathic Parkinson's disease (PD) is a multisytem degenerative disorder. In addition to motor symptoms such as akinesia, rigidity and tremor, various non-motor symptoms occur, which are still insufficiently diagnosed. Moreover, the frequently used scales and scores do not adequately detect these non-motor symptoms. The Non-motor Symptoms Questionnaire (NMSQuest) is an established self-completed
Nanoparticles made from recombinant proteins offer excellent potential for several nanotechnological applications. However, only a very limited number of proteins are currently being used for such purposes due to limited availability and stability. Therefore, we have investigated the enamel matrix protein amelogenin as a new alternative protein for use as recombinant nanoparticles. Amelogenin is a
Preeclampsia remains a major problem worldwide for mothers and babies. Despite intensive study, we have not been able to improve the management or early recognition of preeclampsia. At least part of this is because of failure to standardize the approach to studying this complex syndrome. It is possible that within the syndrome there may be different phenotypes with pathogenic pathways that differ
Recent work has highlighted the potential benefits of exploiting ellipsoidal uncertainty-set-based robust Capon beamformer (RCB) techniques in passive sonar. Regrettably, the computational complexity required to form RCB weights is cubic in the number of adaptive degrees of freedom, which is often prohibitive in practice. For this reason, several low-complexity techniques for computing RCB weights
