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Congenital disorders of glycosylation are a group of rare related disorders causing multisystem dysfunction, including ovarian failure in females that requires early estrogen replacement. Glycosylation defects also disrupt normal synthesis of several coagulation factors, increasing thrombotic risks and complicating hormone replacement. This series describes four females with different types of CDG
Patients admitted to intensive care after cardiac arrest are at risk of circulatory shock and early mortality due to cardiovascular failure. The aim of this study was to evaluate the ability of the veno-arterial pCO2 difference (∆pCO2; central venous CO2 – arterial CO2) and lactate to predict early mortality in postcardiac arrest patients. This was a pre-planned prospective observational sub-study
Power transformers are one of the most costly assets in power grids. Due to increasing electricity demand and levels of distributed generation, they are more and more often loaded above their rated limits. Transformer ratings are traditionally set as static limits, set in a controlled environment with conservative margins. Through dynamic transformer rating, the rating is instead adapted to the ac
The device or the formulation? Which one governs drug dispersibility from the inhaler? To address this question, three budesonide-containing reservoir DPIs: Novopulmon Novolizer®, Giona Easyhaler® and DuoResp Spiromax®, were analyzed using the Next Generation Impactor, NGI. Thereafter, the devices were carefully opened, emptied, and formulations were switched between devices. Finally, three ‘proto
We study the long-time behavior of solutions to quasilinear doubly degenerate parabolic problems of fourth order. The equations model, for instance, the dynamic behavior of a non-Newtonian thin-film flow on a flat impermeable bottom and with zero contact angle. We consider a shear-rate dependent fluid the rheology of which is described by a constitutive power law or Ellis law for the fluid viscosi
The COVID-19 pandemic is a crisis that is "creeping" in its onset and "slow-burning" in its duration. It is characterized by extreme uncertainty, ambiguity, and complexity, presenting an unprecedented need for response across sectors and political-administrative levels. While there has been an explosion of research papers into the national strategies for handling the pandemic, empirical publicatio
Introduction. The cure rate of early stage Hodgkin's lymphoma (HL) is excellent; investigating the late effects of treatment is thus important. Esophageal toxicity is a known side effect in patients receiving radiotherapy (RT) to the mediastinum, although little is known of this in HL survivors. This study investigates the dose to the esophagus in the treatment of early stage HL using different RT
We construct a coarse-grained, structure-based, low-resolution, 6-bead flexible model of bovine serum albumin (BSA, PDB: 4F5S), which is a popular example of a globular protein in biophysical research. The model is obtained via direct Boltzmann inversion using all-atom simulations of a single molecule, and its particular form is selected from a large pool of 6-bead coarse-grained models using two
During the localization process in wireless networks, risks such as Sybil attacks and nodes’ location privacy leakage can exist due to the open and shared nature of wireless networks. However, it is challenging to obtain accurate location for sensor nodes while preserving the privacy of observer nodes who assist in sensor node localization while in the presence of Sybil attacks. Therefore, in this
Despite the ubiquity of the Gaussian process regression model, few theoretical results are available that account for the fact that parameters of the covariance kernel typically need to be estimated from the data set. This article provides one of the first theoretical analyses in the context of Gaussian process regression with a noiseless data set. Specifically, we consider the scenario where the
This paper considers approximate smoothing for discretely observed non-linear stochastic differential equations. The problem is tackled by developing methods for linearising stochastic differential equations with respect to an arbitrary Gaussian process. Two methods are developed based on (1) taking the limit of statistical linear regression of the discretised process and (2) minimising an upper b
In this work, we introduce P3HT (poly(3-hexylthiophene-2,5-diyl)) as an efficient hole transport material (HTM) for lead-free Cs3Sb2I9perovskite-inspired solar cells. The P3HT doubles the power conversion efficiency (PCE) of the solar cells (PCE = 2.5% for the champion device) by improving all of the figures of merit: the fill factor, open-circuit voltage, and the short-circuit current. The maximu
To date, the most efficient perovskite solar cells (PSCs) require hole-transporting materials (HTMs) that are doped with hygroscopic additives to improve their performance. Unfortunately, such dopants negatively impact the overall PSCs stability and add cost and complexity to the device fabrication. Hence, there is a need to investigate new strategies to boost the typically modest performance of d
Post-menopausal women frequently exhibit low bone mineral density, and therefore, evidence-based exercises that induce osteogenic loading and prevent osteoporosis are often essential. The purpose of this study was to investigate the loading intensity of 3 different jumping exercises in post-menopausal women. Fourteen post-menopausal women participated in this study and completed a series of counte
Eccentric exercises are commonly used as a treatment for various muscle and tendon injuries. During complex motions such as the forward lunge, however, it is not always clear which muscles may be contracting eccentrically and at what time. Because this exercise is used during rehabilitation, the purpose of this investigation was to determine what type of contractions take place during two differen
