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Human antibodies generated in vitro may be highly valuable for diagnostic and therapeutic purposes. For a long time most human antibodies produced in vitro have been of the IgM isotype with rather low affinities. In this thesis a method for production of IgG switched antigen-specific human antibodies is presented. This is a two step protocol, in which the first step is a selection procedure of don

Popular Abstract in Swedish Förebyggande av hjärtkärlsjukdom har varit en utmaning för medicinsk forskning under flera decennier. Viktiga frågeställningar om såväl screeningmetodik som risk-faktor intervention söker fortfarande sitt svar och har i sig betydelse för både samhällsmedicin och klinisk verksamhet. Målsättningen för denna studie var att undersöka möjligheten för läkare och sjuksköterskoCardiovascular disease prevention has been a challenge for research for decades. The studies of this thesis were designed to investigate the role of health professionals in everyday clinical work based upon the concept of comprehensive primary care consultation. Routine check-up of blood pressure was the basis for the inclusion in an opportunistic screening for hyperchol-esterolaemia. Additionally

We deal with a natural integer-linear programming formulation of the routing and spectrum allocation (RSA) problem in elastic optical networks. We focus on strengthening the formulation with valid inequalities (cuts). For this purpose we apply clique inequalities that proved to be useful in other applications of this kind. We develop and combine a clique cut generation procedure with a column gene

We find good rate 2/3 and 3/4 convolutional codes for use with iterative decoding (turbo equalization) of coded intersymbol interference with AWGN. The method is based on the input-output bit error rate characteristic of the convolutional BCJR decoder module. An analysis leads to an equivalent minimum distance under the required intrinsic subtraction, which depends on free distance and an input-ou

This paper presents a receiver architecture for intraband dual-carrier reception as specified for the upcoming releases of 3GPP WCDMA and LTE standards. It is based on a time-discrete harmonic rejection complex-IF mixer to limit the bandwidth requirements on the ADCs to that of a single carrier. The mixer has been designed and fabricated together with a 3rd order continuous-time (CT) delta-sigma A

We find effective (homogenized) parameters for Maxwell's equations when the microscopic scale becomes small, but not infinitesimal, compared to the wavelength. The analysis is based on a singular value decomposition of the differential operator in Maxwell's equations

Potential doubling time (Tpot), DNA synthesis time (TS), and labelling index (LI) are fundamental growth kinetics parameters in clinical and experimental cancer research, which may be of further practical importance regarding prognosis and treatment prediction of cancer. They can be measured by bromodeoxyuridine(BrdUrd)/flow cytometry (FCM) methods, where BrdUrd, an analogue of thymidine, is incor

This is a thesis in Criminal Law, with the overall purpose to present an analysis of the legitimacy of the development in the criminal law area that has occurred within the framework of the European Union (EU). More specifically, the thesis will focus on the question of legitimacy of legislative power in criminal matters at the EU level – a question which ultimately is one concerned with the legit

This book is authored based on the Iranian Steel Code (Ed. 2009) and issued outlines of the ministry of higher education for steel structures design 1, 2 courses. It can have a key role in helping the readers to learn steel structures design by ASD method.

A low power wideband low noise amplifier (LNA) was designed and implemented in SiGe HBT technology. The measured noise figure is less than or equal to 1 dB in almost the entire L-band. The gain in the L-band is above 13 dB with a gain variation of 4 dB. Hence, it’s useful for present as well as future GNSS applications. The current consumption is 5 mA from a single supply of +5V. The stability of

Two enzymes involved in the biosynthesis of polyamines, ornithine decarboxylase (ODC, from human and Leishmania donovani) and spermidine synthase (SPDS, from Plasmodium falciparum and Caenorhabditis elegans) were studied using biochemical methods, homology modelling and X-ray crystallography. ODC catalyses the first and committed step in polyamine biosynthesis, the decarboxylation of ornithine to