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BACKGROUND: SLE is associated with significant morbidity, especially in the case of renal involvement. Mitochondrial dysfunction plays a significant role in SLE and may be assessed by measuring mitochondrial DNA (mtDNA) and cytokines reflecting mitochondrial stress (mitokines). Circulating mtDNA is a promising biomarker in SLE and appears to be reduced in severe SLE. However, measuring circulating

Introduction: Supervised physical exercise has been shown to benefit patients with heart failure with preserved/mildly reduced ejection fraction (HFpEF/HfmrEF) by improving symptoms and diastolic function. This study aimed to investigate the correlation between unsupervised daily physical activity and changes in daily pulmonary artery pressure (PAP) in patients with stable NYHA class III heart fai

The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are required for reliable statistical inference of patient data in order to facilitate clinical research. Such integration of national registry data, which requires harmonization of the heterogeneous data sets into a unified view, is facilitated in the Europ

Aims: Increased common carotid artery (CCA) intima media thickness (cIMT) is a well-known risk factor for cardiovascular morbidity and mortality. cIMT thickening has been described in patients with repaired aortic coarctation (CoA), but data on mechanism and clinical relevance in this population are scarce. Our aim was to gain mechanistic insights into cIMT thickening of patients with repaired CoA

There has recently been a considerable attention to the possible role of semiconductor nanowires for future device applications. To make this development feasible, precise control over the growth mechanism is required. In the Vapor-Liquid-Solid growth, the most common growth mechanism, gas phase precursors decompose in presence of catalytic particles and after supersaturating the particles, solid

This thesis concerns growth and characterization of gold-particle seeded nanowires of III-V semiconductor materials (III-V NWs). The nanowires were grown using metal-organic vapour phase epitaxy (MOVPE) and characterized by various microscopy techniques. In particular cross-sectional scanning tunnelling microscopy (XSTM) and cathodoluminescence microscopy (CL) were employed to investigate heterost

Routing is an interesting application for Location Based Services. In order to provide this application on the National Mapping Agencies’ cartographic data the routes must be provided by an external source. The integration of cartographic data and route data is somewhat problematic, why the problems and possible solutions are discussed.

The paper describes a study aiming at importing and integrating route data into a system for real-time map services. Three problems are identified and discussed: importing route data, matching route data, and integrating the matching in the system. A prototype has been developed. It includes the import and translation of the route as well as three matching extensions to an existing matching algori

Broadband services require data rates that can only be achieved by using relatively high spectrum frequencies. At such high frequencies, the DSL (Digital Subscriber Line) signal is more susceptible to external noise sources, such as radio frequency interference and impulsive noise. This paper aims to characterize how the impulsive noise impacts on services and applications for a broadband system u

It is predicted that novel nanometer-sized structures incorporating nanoparticles will have a considerable impact on our lives during the coming decades. Engineered nanoparticles are already found in a number of commercially available products. However, many applications of these nanoparticles have only reached the stage of promising ideas or research demonstrations. The number of nanoparticle-bas